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Protein Ontology report - tumor necrosis factor (human)
PR:P01375 - http://purl.obolibrary.org/obo/PR_P01375
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P01375   
  PRO nametumor necrosis factor (human) 
  Synonyms
PRO-Short-label: EXACT:hTNF
Gene-based: RELATED:TNF | TNFA | TNFSF2
Other: EXACT:cachectin (human) | TNF-a (human) | TNF-alpha (human) | TNFa (human) | tumor necrosis factor ligand superfamily member 2 (human)
  Definition"A tumor necrosis factor that is encoded in the genome of human." [PRO:DNx] 
  CommentRequested by=PubChem. 
  PRO Categoryorganism-gene 
  ParentPR:000000134 tumor necrosis factor
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:11892 TNF (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P01375
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
organism-gene


PR:P01375
tumor necrosis factor (human)
hTNF
"A tumor necrosis factor that is encoded in the genome of human." [PRO:DNx]

Yes
organism-sequence


PR:P01375-1
tumor necrosis factor isoform 1 (human)
hTNF/iso:1
"A tumor necrosis factor isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036504
tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
"A tumor necrosis factor isoform 1 cleaved 1 in human. UniProtKB:P01375-1, 77-233." [PMID:14512626, PMID:3856324, PRO:CNA]
Yes
organism-modification


PR:000036507
tumor necrosis factor isoform 1 myristoylated 1 (human)
hTNF/iso:1/Myr:1
"A tumor necrosis factor isoform 1 myristoylated 1 in human. UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087." [PMID:1402651, PRO:CNA]
Yes
organism-modification


PR:000036508
tumor necrosis factor isoform 1 phosphorylated 1 (human)
hTNF/iso:1/Phos:1
"A tumor necrosis factor isoform 1 phosphorylated 1 in human. UniProtKB:P01375-1, Ser-2, MOD:00046." [PMID:10205166, PMID:8597870, PRO:CNA]
Yes
organism-modification


PR:000051774
tumor necrosis factor O-glycosylated 1 (human)
hTNF/OGlyco:1
"A tumor necrosis factor (human) that has been O-glycosylated at the residue equivalent to Ser-80 of the amino acid sequence represented by UniProtKB:P01375-1, in which the glycan structure is represented by GlyTouCan:G00031MO. Example: UniProtKB:P01375-1, Ser-80, MOD:00002~GNO:G00031MO." [GlyGen:P01375-1, PMID:8631363, PRO:DNx]

organism-modification


PR:000051775
tumor necrosis factor O-glycosylated 2 (human)
hTNF/OGlyco:2
"A tumor necrosis factor (human) that has been O-glycosylated at the residue equivalent to Ser-80 of the amino acid sequence represented by UniProtKB:P01375-1, in which the glycan structure is represented by GlyTouCan:G56682BC. Example: UniProtKB:P01375-1, Ser-80, MOD:00002~GNO:G56682BC." [GlyGen:P01375-1, PMID:8631363, PRO:DNx]

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hTNF forms found in complexes   

hTNF Component
 Complexes
PR:P01375 hTNF PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036504 hTNF/iso:1/Clv:1
UniProtKB:P01375-1, 77-233		 acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:3856324
enablesGO:0005164 tumor necrosis factor receptor binding with PR:P19438 CD120a (human) PMID:14512626
GO:0042802 identical protein binding PMID:14512626
PR:000036507 hTNF/iso:1/Myr:1
UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087		 located_inGO:0016020 membrane PMID:1402651
PR:000036508 hTNF/iso:1/Phos:1
UniProtKB:P01375-1, Ser-2, MOD:00046		 located_inGO:0016020 membrane PMID:10205166
PR:P01375-1 hTNF/iso:1 acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:3856324
located_inGO:0005886 plasma membrane PMID:3349526