back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - tumor necrosis factor (human)
PR:P01375 - http://purl.obolibrary.org/obo/PR_P01375
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P01375   
  PRO nametumor necrosis factor (human) 
  Synonyms
PRO-Short-label: EXACT:hTNF
Gene-based: RELATED:TNF | TNFA | TNFSF2
Other: EXACT:cachectin (human) | TNF-a (human) | TNF-alpha (human) | TNFa (human) | tumor necrosis factor ligand superfamily member 2 (human)
  Definition"A tumor necrosis factor that is encoded in the genome of human." [PRO:DNx] 
  CommentRequested by=PubChem. 
  PRO Categoryorganism-gene 
  ParentPR:000000134 tumor necrosis factor
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:11892 TNF (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
UniProtKB:P01375
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
organism-gene


PR:P01375 tumor necrosis factor (human)
hTNF

Yes
organism-sequence


PR:P01375-1 tumor necrosis factor isoform 1 (human)
hTNF/iso:1
Yes
organism-modification


PR:000036504 tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036507 tumor necrosis factor isoform 1 myristoylated 1 (human)
hTNF/iso:1/Myr:1
Yes
organism-modification


PR:000036508 tumor necrosis factor isoform 1 phosphorylated 1 (human)
hTNF/iso:1/Phos:1
Yes
organism-modification


PR:000051774 tumor necrosis factor O-glycosylated 1 (human)
hTNF/OGlyco:1

organism-modification


PR:000051775 tumor necrosis factor O-glycosylated 2 (human)
hTNF/OGlyco:2

Back to top
hTNF forms found in complexes   

hTNF Component
 Complexes
PR:P01375 hTNF PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
Back to top
Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006915 apoptotic processPR:000036504 hTNF/iso:1/Clv:1 PMID:3856324
PR:P01375-1 hTNF/iso:1 PMID:3856324

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005164 tumor necrosis factor receptor bindingPR:000036504 hTNF/iso:1/Clv:1 PMID:14512626
GO:0042802 identical protein bindingPR:000036504 hTNF/iso:1/Clv:1 PMID:14512626

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005886 plasma membranePR:P01375-1 hTNF/iso:1 PMID:3349526
GO:0016020 membranePR:000036507 hTNF/iso:1/Myr:1 PMID:1402651
PR:000036508 hTNF/iso:1/Phos:1 PMID:10205166