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Protein Ontology report - estrogen receptor (human)
PR:P03372 - http://purl.obolibrary.org/obo/PR_P03372
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P03372   
  PRO nameestrogen receptor (human) 
  Synonyms
PRO-Short-label: EXACT:hESR1
Gene-based: RELATED:ESR | ESR1 | NR3A1
Other: EXACT:ER (human) | ER-alpha (human) | estradiol receptor (human) | nuclear receptor subfamily 3 group A member 1 (human)
  Definition"An estrogen receptor that is encoded in the genome of human." [PRO:DNx, UniProtKB:P03372
  PRO Categoryorganism-gene 
  ParentPR:000007204 estrogen receptor
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:3467 ESR1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 16                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P03372
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
organism-gene



PR:P03372

estrogen receptor (human)

hESR1


"An estrogen receptor that is encoded in the genome of human." [PRO:DNx, UniProtKB:P03372]


organism-sequence



PR:P03372-1

estrogen receptor isoform 1 (human)

hESR1/iso:1


"An estrogen receptor isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000027724

estrogen receptor isoform 1 phosphorylated 1 (human)

hESR1/iso:1/Phos:1


"An estrogen receptor isoform 1 phosphorylated 1 in human. UniProtKB:P03372-1, Ser-167, MOD:00046." [PMID:19940156, PRO:PD]

Yes

organism-modification



PR:000027726

estrogen receptor isoform 1 phosphorylated 2 (human)

hESR1/iso:1/Phos:2


"An estrogen receptor isoform 1 phosphorylated 2 in human. UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048." [PMID:20101225, PRO:PD]

Yes

organism-modification



PR:000027754

estrogen receptor isoform 1 phosphorylated 3 (human)

hESR1/iso:1/Phos:3


"An estrogen receptor isoform 1 phosphorylated 3 in human. UniProtKB:P03372-1, Ser-118, MOD:00046." [PMID:17615152, PRO:PD]


organism-modification



PR:000027756

estrogen receptor isoform 1 acetylated 1 (human)

hESR1/iso:1/Ac:1


"An estrogen receptor isoform 1 acetylated 1 in human. UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064." [PMID:16497729, PRO:PD]

Yes

organism-modification



PR:000027776

estrogen receptor isoform 1 phosphorylated 4 (human)

hESR1/iso:1/Phos:4


"An estrogen receptor isoform 1 phosphorylated 4 in human. UniProtKB:P03372-1, Thr-311, MOD:00047." [PMID:12138194, PRO:PD]

Yes

organism-modification



PR:000027778

estrogen receptor isoform 1 phosphorylated 5 (human)

hESR1/iso:1/Phos:5


"An estrogen receptor isoform 1 phosphorylated 5 in human. UniProtKB:P03372-1, Ser-118/Ser-167, MOD:00046." [PMID:18941890, PRO:PD]


organism-sequence



PR:P03372-2

estrogen receptor isoform h2 (human)

hESR1/iso:h2


"An estrogen receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-2." [PRO:DNx, UniProtKB:P03372]


organism-sequence



PR:P03372-3

estrogen receptor isoform h3 (human)

hESR1/iso:h3


"An estrogen receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-3." [PRO:DNx, UniProtKB:P03372]


organism-modification



PR:000061250

estrogen receptor isoform h3 palmitoylated 1 (human)

hESR1/iso:h3/Palm:1


"An estrogen receptor isoform h3 (human) that has been palmitoylated on the residue at the position equivalent to Cys-274 of the amino acid sequence represented by UniProtKB:P03372-3. UniProtKB:P03372-3, Cys-274, MOD:00115." [PRO:DNx, Reactome:R-HSA-9020991, Reactome:R-HSA-9021055]


organism-modification



PR:000062654

estrogen receptor isoform h3 omega-methylated and palmitoylated 1 (human)

hESR1/iso:h3/Me1oPalm:1


"An estrogen receptor isoform h3 (human) that has been omega-methylated on the residue at the position equivalent to Arg-87 and palmitoylated on the residue at the position equivalent to Cys-274 of the amino acid sequence represented by UniProtKB:P03372-3. UniProtKB:P03372-3, Arg-87, MOD:00078|Cys-274, MOD:00115." [PRO:DNx, Reactome:R-HSA-9637790]


organism-sequence



PR:P03372-4

estrogen receptor isoform h4 (human)

hESR1/iso:h4


"An estrogen receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P03372-4." [PRO:DNx, UniProtKB:P03372]


organism-modification



PR:000063016

estrogen receptor isoform h4 omega-methylated and palmitoylated 1 (human)

hESR1/iso:h4/Me1oPalm:1


"An estrogen receptor isoform h4 (human) that has been omega-methylated on the residue at the position equivalent to Arg-87 and palmitoylated on the residue at the position equivalent to Cys-274 of the amino acid sequence represented by UniProtKB:P03372-4. UniProtKB:P03372-4, Arg-87, MOD:00078|Cys-274, MOD:00115." [PRO:DNx, Reactome:R-HSA-9637786]


organism-modification



PR:000064345

estrogen receptor isoform h4 palmitoylated 1 (human)

hESR1/iso:h4/Palm:1


"An estrogen receptor isoform h4 (human) that has been palmitoylated on the residue at the position equivalent to Cys-274 of the amino acid sequence represented by UniProtKB:P03372-4. UniProtKB:P03372-4, Cys-274, MOD:00115." [PRO:DNx, Reactome:R-HSA-9020988, Reactome:R-HSA-9021053]


organism-modification



PR:000045630

estrogen receptor phosphorylated 1 (human)

hESR1/Phos:1


"An estrogen receptor (human) that has been phosphorylated on the residue at the position equivalent to Tyr-537 of the amino acid sequence represented by UniProtKB:P03372-1. Example: UniProtKB:P03372-1, Tyr-537, MOD:00048." [iPTMnet:P03372, PMID:7539106]


organism-modification



PR:000060689

estrogen receptor omega-methylated 1 (human)

hESR1/Me1o:1


"An estrogen receptor (human) that has been omega-methylated on the residue at the position equivalent to Arg-260 of the amino acid sequence represented by UniProtKB:P03372-1. Example: UniProtKB:P03372-1, Arg-260, MOD:00078." [PRO:DNx, Reactome:R-HSA-9632177]


organism-modification



PR:000061153

estrogen receptor phosphorylated 2 (human)

hESR1/Phos:2


"An estrogen receptor (human) that has been phosphorylated on the residue at the position equivalent to Ser-118 of the amino acid sequence represented by UniProtKB:P03372-1. Example: UniProtKB:P03372-1, Ser-118, MOD:00046." [PRO:DNx, Reactome:R-HSA-9024210]


organism-modification



PR:000061694

estrogen receptor palmitoylated 1 (human)

hESR1/Palm:1


"An estrogen receptor (human) that has been palmitoylated on the residue at the position equivalent to Cys-447 of the amino acid sequence represented by UniProtKB:P03372-1. Example: UniProtKB:P03372-1, Cys-447, MOD:00115." [PRO:DNx, Reactome:R-HSA-9020974, Reactome:R-HSA-9021057]


organism-modification



PR:000063648

estrogen receptor omega-methylated and palmitoylated 1 (human)

hESR1/Me1oPalm:1


"An estrogen receptor (human) that has been omega-methylated on the residue at the position equivalent to Arg-260 and palmitoylated on the residue at the position equivalent to Cys-447 of the amino acid sequence represented by UniProtKB:P03372-1. Example: UniProtKB:P03372-1, Arg-260, MOD:00078|Cys-447, MOD:00115." [PRO:DNx, Reactome:R-HSA-9637788]


organism-modification



PR:000064707

estrogen receptor sumoylated 1 (human)

hESR1/Sumo:1


"An estrogen receptor (human) that has been sumoylated on the residues at the positions equivalent to Lys-266, Lys-268, Lys-299, Lys-302, and Lys-303 of the amino acid sequence represented by UniProtKB:P03372-1. Example: UniProtKB:P03372-1, Lys-266/Lys-268/Lys-299/Lys-302/Lys-303, MOD:01149." [PRO:DNx, Reactome:R-HSA-4090302]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027724 hESR1/iso:1/Phos:1
UniProtKB:P03372-1, Ser-167, MOD:00046
acts_upstream_of_or_withinGO:0045893 positive regulation of DNA-templated transcription PMID:19940156
PR:000027726 hESR1/iso:1/Phos:2
UniProtKB:P03372-1, Tyr-52/Tyr-219, MOD:00048
acts_upstream_of_or_withinGO:0010628 positive regulation of gene expression PMID:20101225
enablesGO:0042803 protein homodimerization activity PMID:20101225
located_inGO:0005634 nucleus PMID:20101225
PR:000027756 hESR1/iso:1/Ac:1
UniProtKB:P03372-1, Lys-266/Lys-268, MOD:00064
enablesGO:0003677 DNA binding PMID:16497729
PR:000027776 hESR1/iso:1/Phos:4
UniProtKB:P03372-1, Thr-311, MOD:00047
acts_upstream_of_or_withinGO:0010628 positive regulation of gene expression PMID:12138194
located_inGO:0005634 nucleus PMID:12138194