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Protein Ontology report - Muellerian-inhibiting factor (human)
PR:P03971 -
http://purl.obolibrary.org/obo/PR_P03971
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:P03971
PRO name
Muellerian-inhibiting factor (human)
Synonyms
PRO-Short-label
:
EXACT:
hAMH
Gene-based
:
RELATED:
AMH | MIF
Other
:
EXACT:
anti-Muellerian hormone (human) | MIS (human) | Muellerian-inhibiting substance (human)
Definition
"A Muellerian-inhibiting factor that is encoded in the genome of human." [PRO:CNA,
UniProtKB:P03971
]
PRO Category
organism-gene
Parent
PR:000000073
Muellerian-inhibiting factor
PR:000029067
Homo sapiens protein
Gene Template
HGNC:464
AMH (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
8
Modification
0
Organism-Modification
4
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:P03971
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
organism-gene
PR:P03971
Muellerian-inhibiting factor (human)
hAMH
"A Muellerian-inhibiting factor that is encoded in the genome of human." [PRO:CNA, UniProtKB:P03971]
organism-sequence
PR:000000221
Muellerian-inhibiting factor sequence variant V12G (human)
hAMH/var:V12G
"A Muellerian-inhibiting factor (human) that has a Gly residue at the position equivalent to Val-12 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Val-12, CHEBI:29947." [PMID:8162013, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000222
Muellerian-inhibiting factor sequence variant L70P (human)
hAMH/var:L70P
"A Muellerian-inhibiting factor (human) that has a Pro residue at the position equivalent to Leu-70 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Leu-70, CHEBI:50342." [PMID:8162013, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000223
Muellerian-inhibiting factor sequence variant G101V (human)
hAMH/var:G101V
"A Muellerian-inhibiting factor (human) that has a Val residue at the position equivalent to Gly-101 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Gly-101, CHEBI:30015." [PMID:8162013, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000224
Muellerian-inhibiting factor sequence variant R123W (human)
hAMH/var:R123W
"A Muellerian-inhibiting factor (human) that has a Trp residue at the position equivalent to Arg-123 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Arg-123, CHEBI:29954." [PMID:8162013, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000225
Muellerian-inhibiting factor sequence variant Y167C (human)
hAMH/var:Y167C
"A Muellerian-inhibiting factor (human) that has a Cys residue at the position equivalent to Tyr-167 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Tyr-167, CHEBI:29950." [PMID:8162013, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000226
Muellerian-inhibiting factor sequence variant R194C (human)
hAMH/var:R194C
"A Muellerian-inhibiting factor (human) that has a Cys residue at the position equivalent to Arg-194 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Arg-194, CHEBI:29950." [PMID:14673134, PMID:8162013, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000227
Muellerian-inhibiting factor sequence variant V477A (human)
hAMH/var:V477A
"A Muellerian-inhibiting factor (human) that has an Ala residue at the position equivalent to Val-477 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Val-477, CHEBI:46217." [PMID:8162013, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:P03971-1
Muellerian-inhibiting factor isoform 1 (human)
hAMH/iso:1
"A Muellerian-inhibiting factor isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification
PR:000036605
Muellerian-inhibiting factor isoform 1 cleaved 1 (human)
hAMH/iso:1/Clv:1
"A Muellerian-inhibiting factor isoform 1 cleaved 1 in human. UniProtKB:P03971-1, 451-560." [PMID:14673134, PRO:CNA]
Yes
organism-modification
PR:000036444
Muellerian-inhibiting factor isoform 1 cleaved and N-glycosylated 2 (human)
hAMH/iso:1/ClvNGlyco:2
"A Muellerian-inhibiting factor isoform 1 cleaved and glycosylated 2 in human, in which the cleaved parts remain joined by disulfide bonds. The position(s) of glycosylation sites have not been experimentally determined. UniProtKB:P03971-1, 26-450, 451-560, MOD:00160." [PMID:12834017, PMID:14673134, PMID:14750901, PMID:3754790, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000053160
Muellerian-inhibiting factor O-glycosylated 1 (human)
hAMH/OGlyco:1
"A Muellerian-inhibiting factor (human) that has been O-glycosylated at the residue equivalent to Thr-353 of the amino acid sequence represented by UniProtKB:P03971-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P03971-1, Thr-353, MOD:00005~GNO:G43417UB." [GlyGen:P03971-1, PMID:30459171, PRO:DNx]
organism-modification
PR:000053161
Muellerian-inhibiting factor O-glycosylated 2 (human)
hAMH/OGlyco:2
"A Muellerian-inhibiting factor (human) that has been O-glycosylated at the residue equivalent to Thr-367 of the amino acid sequence represented by UniProtKB:P03971-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P03971-1, Thr-367, MOD:00005~GNO:G43417UB." [GlyGen:P03971-1, PMID:30459171, PRO:DNx]
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000221
hAMH/var:V12G
UniProtKB:P03971, Val-12, CHEBI:29947
associated_with_disease_progression
DO:0050791
persistent Mullerian duct syndrome
PMID:8162013
PR:000000222
hAMH/var:L70P
UniProtKB:P03971, Leu-70, CHEBI:50342
associated_with_disease_progression
DO:0050791
persistent Mullerian duct syndrome
PMID:8162013
PR:000000223
hAMH/var:G101V
UniProtKB:P03971, Gly-101, CHEBI:30015
associated_with_disease_progression
DO:0050791
persistent Mullerian duct syndrome
PMID:8162013
PR:000000224
hAMH/var:R123W
UniProtKB:P03971, Arg-123, CHEBI:29954
associated_with_disease_progression
DO:0050791
persistent Mullerian duct syndrome
PMID:8162013
PR:000000225
hAMH/var:Y167C
UniProtKB:P03971, Tyr-167, CHEBI:29950
associated_with_disease_progression
DO:0050791
persistent Mullerian duct syndrome
PMID:8162013
PR:000000226
hAMH/var:R194C
UniProtKB:P03971, Arg-194, CHEBI:29950
associated_with_disease_progression
DO:0050791
persistent Mullerian duct syndrome
PMID:14673134
;
PMID:8162013
located_in
SO:0001555
decreased_translational_product_level
PMID:14673134
;
PMID:8162013
SO:0001558
polypeptide_localization_variant
PMID:14673134
;
PMID:8162013
PR:000000227
hAMH/var:V477A
UniProtKB:P03971, Val-477, CHEBI:46217
located_in
SO:0001558
polypeptide_localization_variant
PMID:8162013
PR:000036444
hAMH/iso:1/ClvNGlyco:2
UniProtKB:P03971-1, 26-450, 451-560, MOD:00160
acts_upstream_of_or_within
GO:0001880
Mullerian duct regression
PMID:14750901
;
PMID:3754790
GO:0007267
cell-cell signaling
PMID:3754790
GO:0007548
sex differentiation
PMID:12834017
enables
GO:0005102
signaling receptor binding
PMID:14750901
GO:0005179
hormone activity
PMID:14750901
GO:0046983
protein dimerization activity
PMID:14673134
located_in
GO:0005576
extracellular region
PMID:14750901
;
PMID:3754790
PR:000036605
hAMH/iso:1/Clv:1
UniProtKB:P03971-1, 451-560
enables
GO:0046983
protein dimerization activity
PMID:14673134
PR:P03971-1
hAMH/iso:1
acts_upstream_of_or_within
GO:0001880
Mullerian duct regression
PMID:14750901
GO:0007548
sex differentiation
PMID:12834017
