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Protein Ontology report - apoptosis regulator Bcl-2 isoform Alpha (human)
PR:P10415-1 -
http://purl.obolibrary.org/obo/PR_P10415-1
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:P10415-1
PRO name
apoptosis regulator Bcl-2 isoform Alpha (human)
Synonyms
PRO-Short-label
:
EXACT:
hBCL2/iso:Alpha
Definition
"An apoptosis regulator Bcl-2 isoform 1 that is encoded in the genome of human." [PRO:JAN]
Comment
Requested by=PubChem.
PRO Category
organism-sequence
Parent
PR:000002383
apoptosis regulator Bcl-2 isoform 1
PR:P10415
apoptosis regulator Bcl-2 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
0
Organism-Sequence
1
Modification
0
Organism-Modification
4
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:P10415-1
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
organism-sequence
PR:P10415-1
apoptosis regulator Bcl-2 isoform Alpha (human)
hBCL2/iso:Alpha
"An apoptosis regulator Bcl-2 isoform 1 that is encoded in the genome of human." [PRO:JAN]
Yes
organism-modification
PR:000027461
apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 (human)
hBCL2/iso:1/Phos:2
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 2 in human. UniProtKB:P10415-1, Thr-74, MOD:00047." [PMID:12039864, PRO:PD]
Yes
organism-modification
PR:000027463
apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 (human)
hBCL2/iso:1/Phos:3
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 3 in human. UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046." [PMID:18570871, PMID:19029119, PRO:PD]
Yes
organism-modification
PR:000027465
apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 (human)
hBCL2/iso:1/Phos:4
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 4 in human. UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046." [PMID:15703383, PRO:PD]
Yes
organism-modification
PR:000027467
apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 (human)
hBCL2/iso:1/Phos:5
"An apoptosis regulator Bcl-2 isoform 1 phosphorylated 5 in human. UniProtKB:P10415-1, Thr-56, MOD:00047." [PMID:10766756, PRO:PD]
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000027461
hBCL2/iso:1/Phos:2
UniProtKB:P10415-1, Thr-74, MOD:00047
acts_upstream_of_or_within
GO:0043066
negative regulation of apoptotic process
PMID:12039864
PR:000027463
hBCL2/iso:1/Phos:3
UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046
acts_upstream_of_or_within
GO:0016239
positive regulation of macroautophagy
PMID:18570871
;
PMID:19029119
enables
NOT
GO:0005515
protein binding
with
PR:Q14457
BECN1
PMID:18570871
;
PMID:19029119
PR:000027465
hBCL2/iso:1/Phos:4
UniProtKB:P10415-1, Thr-69, MOD:00047|Ser-87, MOD:00046
acts_upstream_of_or_within
GO:0043065
positive regulation of apoptotic process
PMID:15703383
PR:000027467
hBCL2/iso:1/Phos:5
UniProtKB:P10415-1, Thr-56, MOD:00047
acts_upstream_of_or_within
GO:0045839
negative regulation of mitotic nuclear division
PMID:10766756
PR:P10415-1
hBCL2/iso:Alpha
acts_upstream_of_or_within
GO:0070885
negative regulation of calcineurin-NFAT signaling cascade
PMID:9109491
enables
GO:0005515
protein binding
with
PR:P63328
calcineurin A alpha (mouse)
PMID:9109491
GO:0005515
protein binding
with
PR:Q07813
Bax
PMID:9109491
located_in
GO:0005886
plasma membrane
PMID:9109491