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Protein Ontology report - DNA topoisomerase 2-alpha (human)
PR:P11388 - http://purl.obolibrary.org/obo/PR_P11388
 
  Protein Forms      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P11388   
  PRO nameDNA topoisomerase 2-alpha (human) 
  Synonyms
PRO-Short-label: EXACT:hTOP2A
Gene-based: RELATED:TOP2 | TOP2A
Other: EXACT:DNA topoisomerase II, alpha isozyme (human)
  Definition"A DNA topoisomerase 2-alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11388] 
  PRO Categoryorganism-gene 
  ParentPR:000016544 DNA topoisomerase 2-alpha
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:11989 TOP2A (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 13                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P11388
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
organism-gene


PR:P11388
DNA topoisomerase 2-alpha (human)
hTOP2A
"A DNA topoisomerase 2-alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11388]

organism-sequence


PR:P11388-1
DNA topoisomerase 2-alpha isoform h1 (human)
hTOP2A/iso:h1
"A DNA topoisomerase 2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11388-1." [PRO:DNx, UniProtKB:P11388]

organism-sequence


PR:P11388-2
DNA topoisomerase 2-alpha isoform h2 (human)
hTOP2A/iso:h2
"A DNA topoisomerase 2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11388-2." [PRO:DNx, UniProtKB:P11388]

organism-sequence


PR:P11388-3
DNA topoisomerase 2-alpha isoform h3 (human)
hTOP2A/iso:h3
"A DNA topoisomerase 2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11388-3." [PRO:DNx, UniProtKB:P11388]

organism-sequence


PR:P11388-4
DNA topoisomerase 2-alpha isoform h4 (human)
hTOP2A/iso:h4
"A DNA topoisomerase 2-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11388-4." [PRO:DNx, UniProtKB:P11388]

organism-modification


PR:000064765
DNA topoisomerase 2-alpha sumoylated form (human)
hTOP2A/SumoLys+
"A DNA topoisomerase 2-alpha (human) that includes at least 1 sumoylated lysine. UniProtKB:P11388, MOD:01149." [PRO:DNx, Reactome:R-HSA-4641298, Reactome:R-HSA-4641367]

organism-modification


PR:000065564
DNA topoisomerase 2-alpha deaminated 1 (human)
hTOP2A/Deam:1
"A DNA topoisomerase 2-alpha (human) that has been deaminated on the residue at the position equivalent to Gln-746 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Gln-746, MOD:00685." [IEDB_epitope:1584152, PRO:DNx]

organism-modification


PR:000067662
DNA topoisomerase 2-alpha deaminated 2 (human)
hTOP2A/Deam:2
"A DNA topoisomerase 2-alpha (human) that has been deaminated on the residue at the position equivalent to Asn-782 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Asn-782, MOD:00684." [IEDB_epitope:1582064, PRO:DNx]

organism-modification


PR:000069448
DNA topoisomerase 2-alpha cysteinylated 1 (human)
hTOP2A/Cyst:1
"A DNA topoisomerase 2-alpha (human) that has been cysteinylated on the residue at the position equivalent to Cys-1008 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Cys-1008, MOD:00765." [IEDB_epitope:638451, PRO:DNx]

organism-modification


PR:000071344
DNA topoisomerase 2-alpha deaminated 3 (human)
hTOP2A/Deam:3
"A DNA topoisomerase 2-alpha (human) that has been deaminated on the residue at the position equivalent to Asn-294 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Asn-294, MOD:00684." [IEDB_epitope:928312, PRO:DNx]

organism-modification


PR:000072972
DNA topoisomerase 2-alpha phosphorylated 1 (human)
hTOP2A/Phos:1
"A DNA topoisomerase 2-alpha (human) that has been phosphorylated on the residue at the position equivalent to Ser-29 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Ser-29, MOD:00046." [IEDB_epitope:1360062, IEDB_epitope:927919, PRO:DNx]

organism-modification


PR:000076890
DNA topoisomerase 2-alpha phosphorylated 2 (human)
hTOP2A/Phos:2
"A DNA topoisomerase 2-alpha (human) that has been phosphorylated on the residue at the position equivalent to Ser-30 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Ser-30, MOD:00046." [IEDB_epitope:609594, PRO:DNx]

organism-modification


PR:000077986
DNA topoisomerase 2-alpha deaminated 4 (human)
hTOP2A/Deam:4
"A DNA topoisomerase 2-alpha (human) that has been deaminated on the residue at the position equivalent to Asn-345 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Asn-345, MOD:00684." [IEDB_epitope:996633, PRO:DNx]

organism-modification


PR:000080098
DNA topoisomerase 2-alpha deaminated 5 (human)
hTOP2A/Deam:5
"A DNA topoisomerase 2-alpha (human) that has been deaminated on the residue at the position equivalent to Asn-833 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Asn-833, MOD:00684." [IEDB_epitope:1353270, PRO:DNx]

organism-modification


PR:000080516
DNA topoisomerase 2-alpha cysteinylated 2 (human)
hTOP2A/Cyst:2
"A DNA topoisomerase 2-alpha (human) that has been cysteinylated on the residue at the position equivalent to Cys-170 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Cys-170, MOD:00765." [IEDB_epitope:1024632, PRO:DNx]

organism-modification


PR:000080620
DNA topoisomerase 2-alpha methylated 1 (human)
hTOP2A/Me:1
"A DNA topoisomerase 2-alpha (human) that has been methylated on the residue at the position equivalent to Cys-1008 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Cys-1008, MOD:00660." [IEDB_epitope:1029127, IEDB_epitope:1058044, PRO:DNx]

organism-modification


PR:000084338
DNA topoisomerase 2-alpha deaminated 6 (human)
hTOP2A/Deam:6
"A DNA topoisomerase 2-alpha (human) that has been deaminated on the residue at the position equivalent to Asn-917 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Asn-917, MOD:00684." [IEDB_epitope:1341909, PRO:DNx]

organism-modification


PR:000085682
DNA topoisomerase 2-alpha methylated 2 (human)
hTOP2A/Me:2
"A DNA topoisomerase 2-alpha (human) that has been methylated on the residue at the position equivalent to Cys-300 of the amino acid sequence represented by UniProtKB:P11388-1. Example: UniProtKB:P11388-1, Cys-300, MOD:00660." [IEDB_epitope:1019210, PRO:DNx]