back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - ezrin (human)
PR:P15311 - http://purl.obolibrary.org/obo/PR_P15311
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P15311   
  PRO nameezrin (human) 
  Synonyms
PRO-Short-label: EXACT:hEZR
Gene-based: RELATED:EZR | VIL2
Other: EXACT:cytovillin (human) | villin-2 (human)
  Definition"An ezrin that is encoded in the genome of human." [PRO:CNA, UniProtKB:P15311] 
  PRO Categoryorganism-gene 
  ParentPR:000001031 ezrin
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:12691 EZR (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
UniProtKB:P15311
Back to top
Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
organism-gene


PR:P15311
ezrin (human)
hEZR
"An ezrin that is encoded in the genome of human." [PRO:CNA, UniProtKB:P15311]

organism-sequence


PR:P15311-1
ezrin isoform 1 (human)
hEZR/iso:1
"An ezrin isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000036588
ezrin isoform 1 phosphorylated 1 (human)
hEZR/iso:1/Phos:1
"An ezrin isoform 1 phosphorylated 1 in human. UniProtKB:P15311-1, Tyr-146/Tyr-354, MOD:00048." [PMID:1382070, PRO:CNA]

organism-modification


PR:000036589
ezrin isoform 1 phosphorylated 2 (human)
hEZR/iso:1/Phos:2
"An ezrin isoform 1 phosphorylated 2 in human. UniProtKB:P15311-1, Ser-66, MOD:00046." [PMID:12840026, PMID:16438931, PRO:CNA]
Yes
organism-modification


PR:000036590
ezrin isoform 1 phosphorylated 3 (human)
hEZR/iso:1/Phos:3
"An ezrin isoform 1 phosphorylated 3 in human. UniProtKB:P15311-1, Tyr-191, MOD:00048." [PMID:15647376, PRO:CNA]
Yes
organism-modification


PR:000036591
ezrin isoform 1 phosphorylated 4 (human)
hEZR/iso:1/Phos:4
"An ezrin isoform 1 phosphorylated 4 in human. UniProtKB:P15311-1, Tyr-146/Tyr-191, MOD:00048|Thr-567, MOD:00047." [PMID:15647376, PRO:CNA]

organism-modification


PR:000036592
ezrin isoform 1 phosphorylated 5 (human)
hEZR/iso:1/Phos:5
"An ezrin isoform 1 phosphorylated 5 in human. UniProtKB:P15311-1, Thr-567, MOD:00047." [PMID:16144865, PMID:18025306, PRO:AL, PRO:CNA]
Yes
organism-modification


PR:000036625
ezrin isoform 1 phosphorylated 6 (human)
hEZR/iso:1/Phos:6
"An ezrin isoform 1 phosphorylated 6 in human. UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047." [PMID:18852256, PRO:AL]
Yes
organism-modification


PR:000047345
ezrin, initiator methionine removed phosphorylated 5 (human)
hEZR/InitMet-/Phos:5
"An ezrin (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 567 of the amino acid sequence represented by UniProtKB:P15311. UniProtKB:P15311, 2-586, Thr-567, MOD:00047." [PRO:DNx, Reactome:R-HSA-374559]

organism-modification


PR:000047346
ezrin, initiator methionine removed phosphorylated 1 (human)
hEZR/InitMet-/Phos:1
"An ezrin (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at positions 146 and 354 of the amino acid sequence represented by UniProtKB:P15311. UniProtKB:P15311, 2-586, Tyr-146/Tyr-354, MOD:00048." [PRO:DNx, Reactome:R-HSA-374572]

Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036589 hEZR/iso:1/Phos:2
UniProtKB:P15311-1, Ser-66, MOD:00046		 enablesGO:0005515 protein binding with PR:000002696 WWOX/iso:1/UnMod PMID:16438931
PR:000036590 hEZR/iso:1/Phos:3
UniProtKB:P15311-1, Tyr-191, MOD:00048		 enablesGO:0005515 protein binding with PR:P00523-1 PMID:15647376
PR:000036592 hEZR/iso:1/Phos:5
UniProtKB:P15311-1, Thr-567, MOD:00047		 acts_upstream_of_or_withinGO:0001771 immunological synapse formation PMID:18025306
GO:0051279 regulation of release of sequestered calcium ion into cytosol PMID:18025306
enablesGO:0005515 protein binding with PR:P43403 70 kDa zeta-chain associated protein (human) PMID:18025306
located_inGO:0001772 immunological synapse PMID:18025306
GO:0045177 apical part of cell PMID:16144865
PR:000036625 hEZR/iso:1/Phos:6
UniProtKB:P15311-1, Tyr-354, MOD:00048|Thr-567, MOD:00047		 enablesGO:0003779 actin binding PMID:18852256
located_inGO:0002102 podosome PMID:18852256
GO:0005886 plasma membrane PMID:18852256