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Protein Ontology report - DNA (cytosine-5)-methyltransferase 1 (human)
PR:P26358 - http://purl.obolibrary.org/obo/PR_P26358
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P26358   
  PRO nameDNA (cytosine-5)-methyltransferase 1 (human) 
  Synonyms
PRO-Short-label: EXACT:hDNMT1
Gene-based: RELATED:AIM | CXXC9 | DNMT | DNMT1
Other: EXACT:CXXC-type zinc finger protein 9 (human) | DNA methyltransferase HsaI (human) | DNA MTase HsaI (human) | Dnmt1 (human) | M.HsaI (human) | MCMT (human)
  Definition"A DNA (cytosine-5)-methyltransferase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P26358
  PRO Categoryorganism-gene 
  ParentPR:000006606 DNA (cytosine-5)-methyltransferase 1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:2976 DNMT1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 16                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P26358
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
organism-gene



PR:P26358

DNA (cytosine-5)-methyltransferase 1 (human)

hDNMT1


"A DNA (cytosine-5)-methyltransferase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P26358]


organism-sequence



PR:P26358-1

DNA (cytosine-5)-methyltransferase 1 isoform 1 (human)

hDNMT1/iso:1


"A DNA (cytosine-5)-methyltransferase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P26358-1." [PRO:DNx, UniProtKB:P26358]


organism-sequence



PR:P26358-2

DNA (cytosine-5)-methyltransferase 1 isoform h2 (human)

hDNMT1/iso:h2


"A DNA (cytosine-5)-methyltransferase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P26358-2." [PRO:DNx, UniProtKB:P26358]


organism-sequence



PR:P26358-3

DNA (cytosine-5)-methyltransferase 1 isoform h3 (human)

hDNMT1/iso:h3


"A DNA (cytosine-5)-methyltransferase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P26358-3." [PRO:DNx, UniProtKB:P26358]


organism-modification



PR:000037504

DNA (cytosine-5)-methyltransferase 1 unphosphorylated 1 (human)

hDNMT1/UnPhos:1


"A DNA (cytosine-5)-methyltransferase 1 (human) that lacks phosphorylation on residues at positions equivalent to Ser-127 and Ser-143 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Ser-127/Ser-143, PR:000026291." [PMID:20613874, PRO:KER]

Yes

Yes
organism-modification



PR:000037505

DNA (cytosine-5)-methyltransferase 1 phosphorylated 1 (human)

hDNMT1/Phos:1


"A DNA (cytosine-5)-methyltransferase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-127 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Ser-127, MOD:00046." [PMID:20613874, PRO:KER]

Yes

organism-modification



PR:000037506

DNA (cytosine-5)-methyltransferase 1 phosphorylated 2 (human)

hDNMT1/Phos:2


"A DNA (cytosine-5)-methyltransferase 1 (human) that has been phosphorylated on residues at positions to Ser-127 and Ser-143 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Ser-127/Ser-143, MOD:00046." [PMID:20613874, PRO:KER]

Yes

organism-modification



PR:000064669

DNA (cytosine-5)-methyltransferase 1 sumoylated form (human)

hDNMT1/SumoLys+


"A DNA (cytosine-5)-methyltransferase 1 (human) that includes at least 1 sumoylated lysine. UniProtKB:P26358, MOD:01149." [PRO:DNx, Reactome:R-HSA-4655353]


organism-modification



PR:000064966

DNA (cytosine-5)-methyltransferase 1 cysteinylated 1 (human)

hDNMT1/Cyst:1


"A DNA (cytosine-5)-methyltransferase 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-1485 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Cys-1485, MOD:00765." [IEDB_epitope:927174, PRO:DNx]


organism-modification



PR:000072937

DNA (cytosine-5)-methyltransferase 1 deaminated 1 (human)

hDNMT1/Deam:1


"A DNA (cytosine-5)-methyltransferase 1 (human) that has been deaminated on the residue at the position equivalent to Asn-87 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Asn-87, MOD:00684." [IEDB_epitope:1320812, PRO:DNx]


organism-modification



PR:000073186

DNA (cytosine-5)-methyltransferase 1 methylated 1 (human)

hDNMT1/Me:1


"A DNA (cytosine-5)-methyltransferase 1 (human) that has been methylated on the residue at the position equivalent to Cys-409 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Cys-409, MOD:00660." [IEDB_epitope:1000579, PRO:DNx]


organism-modification



PR:000075247

DNA (cytosine-5)-methyltransferase 1 cysteinylated 2 (human)

hDNMT1/Cyst:2


"A DNA (cytosine-5)-methyltransferase 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-62 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Cys-62, MOD:00765." [IEDB_epitope:929733, PRO:DNx]


organism-modification



PR:000076392

DNA (cytosine-5)-methyltransferase 1 hydroxylated 1 (human)

hDNMT1/Hy:1


"A DNA (cytosine-5)-methyltransferase 1 (human) that has been hydroxylated on the residue at the position equivalent to Trp-843 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Trp-843, MOD:01622." [IEDB_epitope:1319207, PRO:DNx]


organism-modification



PR:000077299

DNA (cytosine-5)-methyltransferase 1 methylated 2 (human)

hDNMT1/Me:2


"A DNA (cytosine-5)-methyltransferase 1 (human) that has been methylated on the residue at the position equivalent to Cys-62 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Cys-62, MOD:00660." [IEDB_epitope:1038477, PRO:DNx]


organism-modification



PR:000077374

DNA (cytosine-5)-methyltransferase 1 methylated 3 (human)

hDNMT1/Me:3


"A DNA (cytosine-5)-methyltransferase 1 (human) that has been methylated on the residue at the position equivalent to Cys-1001 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Cys-1001, MOD:00660." [IEDB_epitope:1041963, PRO:DNx]


organism-modification



PR:000077466

DNA (cytosine-5)-methyltransferase 1 methylated 4 (human)

hDNMT1/Me:4


"A DNA (cytosine-5)-methyltransferase 1 (human) that has been methylated on the residue at the position equivalent to Cys-1294 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Cys-1294, MOD:00660." [IEDB_epitope:1059173, PRO:DNx]


organism-modification



PR:000081489

DNA (cytosine-5)-methyltransferase 1 methylated 5 (human)

hDNMT1/Me:5


"A DNA (cytosine-5)-methyltransferase 1 (human) that has been methylated on the residue at the position equivalent to Cys-1060 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Cys-1060, MOD:00660." [IEDB_epitope:1003499, IEDB_epitope:1058947, PRO:DNx]


organism-modification



PR:000082192

DNA (cytosine-5)-methyltransferase 1 deaminated 2 (human)

hDNMT1/Deam:2


"A DNA (cytosine-5)-methyltransferase 1 (human) that has been deaminated on the residue at the position equivalent to Asn-94 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Asn-94, MOD:00684." [IEDB_epitope:1587097, IEDB_epitope:762785, PRO:DNx]


organism-modification



PR:000082488

DNA (cytosine-5)-methyltransferase 1 cysteinylated 3 (human)

hDNMT1/Cyst:3


"A DNA (cytosine-5)-methyltransferase 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-1001 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Cys-1001, MOD:00765." [IEDB_epitope:1016527, IEDB_epitope:636165, PRO:DNx]


organism-modification



PR:000084790

DNA (cytosine-5)-methyltransferase 1 cysteinylated 4 (human)

hDNMT1/Cyst:4


"A DNA (cytosine-5)-methyltransferase 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-409 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Cys-409, MOD:00765." [IEDB_epitope:1000578, PRO:DNx]


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hDNMT1 forms found in complexes   

hDNMT1 Component
Complexes
PR:000037504 hDNMT1/UnPhos:1 PR:000037517 DNMT1:PCNA:UHRF1 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037504 hDNMT1/UnPhos:1
Example: UniProtKB:P26358-1, Ser-127/Ser-143, PR:000026291
enablesGO:0005515 protein binding with PR:P12004 cyclin (human) PMID:20613874
GO:0005515 protein binding with PR:Q96T88 hNp95 PMID:20613874
PR:000037505 hDNMT1/Phos:1
Example: UniProtKB:P26358-1, Ser-127, MOD:00046
enablesdecreased GO:0005515 protein binding with PR:P12004 cyclin (human) PMID:20613874
decreased GO:0005515 protein binding with PR:Q96T88 hNp95 PMID:20613874
PR:000037506 hDNMT1/Phos:2
Example: UniProtKB:P26358-1, Ser-127/Ser-143, MOD:00046
enablesdecreased GO:0005515 protein binding with PR:P12004 cyclin (human) PMID:20613874
decreased GO:0005515 protein binding with PR:Q96T88 hNp95 PMID:20613874