back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - mitogen-activated protein kinase 1 (human)
PR:P28482 - http://purl.obolibrary.org/obo/PR_P28482
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P28482   
  PRO namemitogen-activated protein kinase 1 (human) 
  Synonyms
PRO-Short-label: EXACT:hMAPK1
Gene-based: RELATED:ERK2 | MAPK1 | PRKM1 | PRKM2
Other: EXACT:ERK-2 (human) | ERT1 (human) | extracellular signal-regulated kinase 2 (human) | MAP kinase 1 (human) | MAP kinase 2 (human) | MAP kinase isoform p42 (human) | MAPK 1 (human) | MAPK 2 (human) | mitogen-activated protein kinase 2 (human) | p42-MAPK (human)
  Definition"A mitogen-activated protein kinase 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P28482
  PRO Categoryorganism-gene 
  ParentPR:000000103 mitogen-activated protein kinase 1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:6871 MAPK1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 17                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
UniProtKB:P28482
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
organism-gene



PR:P28482

mitogen-activated protein kinase 1 (human)

hMAPK1


"A mitogen-activated protein kinase 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P28482]


organism-sequence



PR:P28482-1

mitogen-activated protein kinase 1 isoform 1 (human)

hMAPK1/iso:1


"A mitogen-activated protein kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026341

mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human)

hMAPK1/iso:1/Phos:1


"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, UniProtKB:P28482]

Yes

organism-sequence



PR:P28482-2

mitogen-activated protein kinase 1 isoform h2 (human)

hMAPK1/iso:h2


"A mitogen-activated protein kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28482-2." [PRO:DNx, UniProtKB:P28482]


organism-modification



PR:000045734

mitogen-activated protein kinase 1 phosphorylated 1 (human)

hMAPK1/Phos:1


"A mitogen-activated protein kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-29 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, Ser-29, MOD:00046." [iPTMnet:P28482, PMID:19447520]


organism-modification



PR:000048313

mitogen-activated protein kinase 1, initiator methionine removed form (human)

hMAPK1/InitMet-


"A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed. UniProtKB:P28482, 2-360." [PRO:DNx, Reactome:R-HSA-199960, Reactome:R-HSA-59282]


organism-modification



PR:000048314

mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 1 (human)

hMAPK1/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 185, and phosphotyrosine at position 187 of the amino acid sequence represented by UniProtKB:P28482. UniProtKB:P28482, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-109853, Reactome:R-HSA-112354]


organism-modification



PR:000060366

mitogen-activated protein kinase 1 sequence variant D321V, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:D321V/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Val residue at the position equivalent to Asp-321 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185/Tyr-187, MOD:00048|Asp-321, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9652791]


organism-modification



PR:000060482

mitogen-activated protein kinase 1 sequence variant E322K, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:E322K/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Lys residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185/Tyr-187, MOD:00048|Glu-322, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-9652175]


organism-modification



PR:000061403

mitogen-activated protein kinase 1 sequence variant P58G, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:P58G/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Gly residue at the position equivalent to Pro-58 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Pro-58, CHEBI:29947|Thr-185/Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652802]


organism-modification



PR:000061840

mitogen-activated protein kinase 1 sequence variant E81K, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:E81K/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Lys residue at the position equivalent to Glu-81 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Glu-81, CHEBI:29967|Thr-185/Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652799]


organism-modification



PR:000062009

mitogen-activated protein kinase 1 sequence variant E322V, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:E322V/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Val residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185/Tyr-187, MOD:00048|Glu-322, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9652797]


organism-modification



PR:000062395

mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 2 (human)

hMAPK1/InitMet-/Phos:2


"A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Thr-185 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047." [PRO:DNx, Reactome:R-HSA-9635773]


organism-modification



PR:000062794

mitogen-activated protein kinase 1 sequence variant D321N, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:D321N/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has an Asn residue at the position equivalent to Asp-321 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185/Tyr-187, MOD:00048|Asp-321, CHEBI:50347." [PRO:DNx, Reactome:R-HSA-9652785]


organism-modification



PR:000062965

mitogen-activated protein kinase 1 sequence variant P58L, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:P58L/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Leu residue at the position equivalent to Pro-58 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Pro-58, CHEBI:30006|Thr-185/Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652806]


organism-modification



PR:000063285

mitogen-activated protein kinase 1 sequence variant S142L, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:S142L/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Leu residue at the position equivalent to Ser-142 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Ser-142, CHEBI:30006|Thr-185/Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652808]


organism-modification



PR:000063321

mitogen-activated protein kinase 1 sequence variant E322A, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:E322A/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has an Ala residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185/Tyr-187, MOD:00048|Glu-322, CHEBI:46217." [PRO:DNx, Reactome:R-HSA-9652794]


organism-modification



PR:000083225

mitogen-activated protein kinase 1 cysteinylated 1 (human)

hMAPK1/Cyst:1


"A mitogen-activated protein kinase 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-127 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, Cys-127, MOD:00765." [IEDB_epitope:1573500, PRO:DNx]


organism-modification



PR:000083581

mitogen-activated protein kinase 1 methylated 1 (human)

hMAPK1/Me:1


"A mitogen-activated protein kinase 1 (human) that has been methylated on the residue at the position equivalent to Cys-166 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, Cys-166, MOD:00660." [IEDB_epitope:1024100, PRO:DNx]


organism-modification



PR:000084106

mitogen-activated protein kinase 1 methylated 2 (human)

hMAPK1/Me:2


"A mitogen-activated protein kinase 1 (human) that has been methylated on the residue at the position equivalent to Cys-127 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, Cys-127, MOD:00660." [IEDB_epitope:1018447, PRO:DNx]


Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026341 hMAPK1/iso:1/Phos:1
UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048
acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:10958679
GO:0006935 chemotaxis PMID:10706854
GO:0007165 signal transduction PMID:1540184
enablesGO:0004672 protein kinase activity PMID:10706854
GO:0004707 MAP kinase activity PMID:10706854
GO:0005515 protein binding PMID:16291755
PR:P28482-1 hMAPK1/iso:1 acts_upstream_of_or_withinGO:0006935 chemotaxis PMID:10706854
GO:0006950 response to stress PMID:10958679
GO:0007268 chemical synaptic transmission PMID:10706854
enablesNOT GO:0004707 MAP kinase activity PMID:10706854