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Protein Ontology report - protein PML (human)
PR:P29590 - http://purl.obolibrary.org/obo/PR_P29590
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P29590   
  PRO nameprotein PML (human) 
  Synonyms
PRO-Short-label: EXACT:hPML
Gene-based: RELATED:MYL | PML | PP8675 | RNF71 | TRIM19
Other: EXACT:E3 SUMO-protein ligase PML (human) | promyelocytic leukemia protein (human) | RING finger protein 71 (human) | RING-type E3 SUMO transferase PML (human) | tripartite motif-containing protein 19 (human)
  Definition"A transcription factor PML that is encoded in the genome of human." [PRO:CNA, UniProtKB:P29590
  PRO Categoryorganism-gene 
  ParentPR:000026474 transcription factor PML
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:9113 PML (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 12                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P29590
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
organism-gene



PR:P29590

protein PML (human)

hPML


"A transcription factor PML that is encoded in the genome of human." [PRO:CNA, UniProtKB:P29590]


organism-sequence



PR:P29590-1

transcription factor PML isoform 1 (human)

hPML/iso:1


"A transcription factor PML isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026480

transcription factor PML isoform 1 phosphorylated 1 (human)

hPML/iso:1/Phos:1


"A transcription factor PML isoform 1 phosphorylated 1 in human. UniProtKB:P29590-1, Ser-403, MOD:00046|Thr-409, MOD:00047." [PMID:20832753, PRO:CNA]

Yes

organism-sequence



PR:P29590-10

protein PML isoform hPML-7 (human)

hPML/iso:hPML-7


"A protein PML (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29590-10." [PRO:DNx, UniProtKB:P29590]


organism-sequence



PR:P29590-11

protein PML isoform hPML-11 (human)

hPML/iso:hPML-11


"A protein PML (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29590-11." [PRO:DNx, UniProtKB:P29590]


organism-sequence



PR:P29590-12

protein PML isoform hPML-12 (human)

hPML/iso:hPML-12


"A protein PML (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29590-12." [PRO:DNx, UniProtKB:P29590]


organism-sequence



PR:P29590-13

protein PML isoform hPML-13 (human)

hPML/iso:hPML-13


"A protein PML (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29590-13." [PRO:DNx, UniProtKB:P29590]


organism-sequence



PR:P29590-14

protein PML isoform hPML-14 (human)

hPML/iso:hPML-14


"A protein PML (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29590-14." [PRO:DNx, UniProtKB:P29590]


organism-sequence



PR:P29590-2

transcription factor PML isoform 2 (human)

hPML/iso:2


"A transcription factor PML isoform 2 that is encoded in the genome of human." [PMID:16778193]

Yes

organism-sequence



PR:P29590-3

transcription factor PML isoform 3 (human)

hPML/iso:3


"A transcription factor PML isoform 3 that is encoded in the genome of human." [PMID:9395203]

Yes

organism-sequence



PR:P29590-4

transcription factor PML isoform 4 (human)

hPML/iso:4


"A transcription factor PML isoform 4 that is encoded in the genome of human." [PMID:8643677]

Yes

organism-sequence



PR:P29590-5

transcription factor PML isoform 5 (human)

hPML/iso:5


"A transcription factor PML isoform 5 that is encoded in the genome of human." [PMID:15195100]

Yes

organism-sequence



PR:P29590-8

protein PML isoform hPML-2 (human)

hPML/iso:hPML-2


"A protein PML (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29590-8." [PRO:DNx, UniProtKB:P29590]


organism-sequence



PR:P29590-9

protein PML isoform hPML-3 (human)

hPML/iso:hPML-3


"A protein PML (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29590-9." [PRO:DNx, UniProtKB:P29590]


organism-modification



PR:000064635

protein PML sumoylated 1 (human)

hPML/Sumo:1


"A protein PML (human) that has been sumoylated on the residues at the positions equivalent to Lys-65, Lys-160, and Lys-490 of the amino acid sequence represented by UniProtKB:P29590-1. Example: UniProtKB:P29590-1, Lys-65/Lys-160/Lys-490, MOD:01149." [PRO:DNx, Reactome:R-HSA-3000386, Reactome:R-HSA-3000423, Reactome:R-HSA-3000440]


organism-modification



PR:000076676

protein PML methylated 1 (human)

hPML/Me:1


"A protein PML (human) that has been methylated on the residue at the position equivalent to Cys-129 of the amino acid sequence represented by UniProtKB:P29590-1. Example: UniProtKB:P29590-1, Cys-129, MOD:00660." [IEDB_epitope:1038392, PRO:DNx]


organism-modification



PR:000079131

protein PML methylated 2 (human)

hPML/Me:2


"A protein PML (human) that has been methylated on the residue at the position equivalent to Cys-227 of the amino acid sequence represented by UniProtKB:P29590-1. Example: UniProtKB:P29590-1, Cys-227, MOD:00660." [IEDB_epitope:1049140, PRO:DNx]


organism-modification



PR:000080018

protein PML cysteinylated 1 (human)

hPML/Cyst:1


"A protein PML (human) that has been cysteinylated on the residue at the position equivalent to Cys-151 of the amino acid sequence represented by UniProtKB:P29590-1. Example: UniProtKB:P29590-1, Cys-151, MOD:00765." [IEDB_epitope:927514, PRO:DNx]


organism-modification



PR:000082789

protein PML cysteinylated 2 (human)

hPML/Cyst:2


"A protein PML (human) that has been cysteinylated on the residue at the position equivalent to Cys-777 of the amino acid sequence represented by UniProtKB:P29590-1. Example: UniProtKB:P29590-1, Cys-777, MOD:00765." [IEDB_epitope:1594153, PRO:DNx]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0002230 positive regulation of defense response to virus by hostPR:P29590-2 hPML/iso:2 PMID:16873256
PR:P29590-4 hPML/iso:4 PMID:16873257
GO:0006605 protein targetingPR:P29590-5 hPML/iso:5 PMID:15195100
PR:P29590-5 hPML/iso:5 PMID:15195100
GO:0006915 apoptotic processPR:P29590-3 hPML/iso:3 PMID:9583681
PR:P29590-5 hPML/iso:5 PMID:11080164
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damagePR:P29590-5 hPML/iso:5 PMID:12402044
GO:0030308 negative regulation of cell growthPR:P29590-3 hPML/iso:3 PMID:9583681
PR:P29590-3 hPML/iso:3 PMID:9583681
PR:P29590-3 hPML/iso:3 PMID:9583681
PR:P29590-3 hPML/iso:3 PMID:9583681
PR:P29590-3 hPML/iso:3 PMID:9583681
PR:P29590-3 hPML/iso:3 PMID:9583681
PR:P29590-5 hPML/iso:5 PMID:9448006
GO:0030578 PML body organizationPR:P29590-3 hPML/iso:3 PMID:10779416
PR:P29590-4 hPML/iso:4 PMID:8643677
GO:0032938 negative regulation of translation in response to oxidative stressPR:P29590-5 hPML/iso:5 PMID:16915281
GO:0045892 negative regulation of DNA-templated transcriptionPR:P29590-5 hPML/iso:5 PMID:9448006
GO:0045930 negative regulation of mitotic cell cyclePR:P29590-3 hPML/iso:3 PMID:9395203
GO:0050821 protein stabilizationPR:P29590-5 hPML/iso:5 PMID:12773567
GO:0051726 regulation of cell cyclePR:P29590-3 hPML/iso:3 PMID:9583681
PR:P29590-5 hPML/iso:5 PMID:12773567

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0003713 transcription coactivator activityPR:P29590-5 hPML/iso:5 PMID:15626733
PR:P29590-5 hPML/iso:5 PMID:15626733
GO:0005515 protein bindingPR:P29590-1 hPML/iso:1 PMID:20832753
PR:P29590-3 hPML/iso:3 PMID:10610177
PR:P29590-3 hPML/iso:3 PMID:10610177
PR:P29590-3 hPML/iso:3 PMID:10610177
PR:P29590-3 hPML/iso:3 PMID:10610177
PR:P29590-4 hPML/iso:4 PMID:10669754
PR:P29590-4 hPML/iso:4 PMID:10669754
PR:P29590-4 hPML/iso:4 PMID:10669754
PR:P29590-4 hPML/iso:4 PMID:10669754
PR:P29590-4 hPML/iso:4 PMID:10669754
PR:P29590-4 hPML/iso:4 PMID:10669754
PR:P29590-4 hPML/iso:4 PMID:10669754
PR:P29590-5 hPML/iso:5 PMID:11259576
PR:P29590-5 hPML/iso:5 PMID:11259576
PR:P29590-5 hPML/iso:5 PMID:11259576
PR:P29590-5 hPML/iso:5 PMID:11259576
PR:P29590-5 hPML/iso:5 PMID:11259576
PR:P29590-5 hPML/iso:5 PMID:11259576
PR:P29590-5 hPML/iso:5 PMID:11259576
PR:P29590-5 hPML/iso:5 PMID:11259576
PR:P29590-5 hPML/iso:5 PMID:11259576
PR:P29590-5 hPML/iso:5 PMID:11259576
PR:P29590-5 hPML/iso:5 PMID:11259576
PR:P29590-5 hPML/iso:5 PMID:11259576
GO:0008270 zinc ion bindingPR:P29590-4 hPML/iso:4 PMID:7729428
GO:0046982 protein heterodimerization activityPR:P29590-3 hPML/iso:3 PMID:7935403
GO:0050897 cobalt ion bindingPR:P29590-4 hPML/iso:4 PMID:7729428

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005634 nucleusPR:000026480 hPML/iso:1/Phos:1 PMID:20832753
PR:P29590-1 hPML/iso:1 PMID:16778193
PR:P29590-2 hPML/iso:2 PMID:16778193
PR:P29590-3 hPML/iso:3 PMID:9294197
GO:0005730 nucleolusPR:P29590-5 hPML/iso:5 PMID:16778193
GO:0005737 cytoplasmPR:P29590-1 hPML/iso:1 PMID:9885291
PR:P29590-1 hPML/iso:1 PMID:9885291
PR:P29590-1 hPML/iso:1 PMID:9885291
PR:P29590-1 hPML/iso:1 PMID:9885291
PR:P29590-2 hPML/iso:2 PMID:16778193
PR:P29590-3 hPML/iso:3 PMID:16778193
PR:P29590-5 hPML/iso:5 PMID:16778193
GO:0016363 nuclear matrixPR:P29590-5 hPML/iso:5 PMID:11080164
GO:0016605 PML bodyPR:P29590-4 hPML/iso:4 PMID:9885291
PR:P29590-5 hPML/iso:5 PMID:9448006
GO:0031965 nuclear membranePR:P29590-3 hPML/iso:3 PMID:16778193