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Protein Ontology report - protein PML (human)
PR:P29590 -
http://purl.obolibrary.org/obo/PR_P29590
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:P29590
PRO name
protein PML (human)
Synonyms
PRO-Short-label
:
EXACT:
hPML
Gene-based
:
RELATED:
MYL | PML | PP8675 | RNF71 | TRIM19
Other
:
EXACT:
E3 SUMO-protein ligase PML (human) | promyelocytic leukemia protein (human) | RING finger protein 71 (human) | RING-type E3 SUMO transferase PML (human) | tripartite motif-containing protein 19 (human)
Definition
"A transcription factor PML that is encoded in the genome of human." [PRO:CNA,
UniProtKB:P29590
]
PRO Category
organism-gene
Parent
PR:000026474
transcription factor PML
PR:000029067
Homo sapiens protein
Gene Template
HGNC:9113
PML (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
12
Modification
0
Organism-Modification
6
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:P29590
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
comp.
In Complex?
organism-gene
PR:P29590
protein PML (human)
hPML
organism-sequence
PR:P29590-1
transcription factor PML isoform 1 (human)
hPML/iso:1
Yes
organism-modification
PR:000026480
transcription factor PML isoform 1 phosphorylated 1 (human)
hPML/iso:1/Phos:1
Yes
organism-sequence
PR:P29590-10
protein PML isoform hPML-7 (human)
hPML/iso:hPML-7
organism-sequence
PR:P29590-11
protein PML isoform hPML-11 (human)
hPML/iso:hPML-11
organism-sequence
PR:P29590-12
protein PML isoform hPML-12 (human)
hPML/iso:hPML-12
organism-sequence
PR:P29590-13
protein PML isoform hPML-13 (human)
hPML/iso:hPML-13
organism-sequence
PR:P29590-14
protein PML isoform hPML-14 (human)
hPML/iso:hPML-14
organism-sequence
PR:P29590-2
transcription factor PML isoform 2 (human)
hPML/iso:2
Yes
organism-sequence
PR:P29590-3
transcription factor PML isoform 3 (human)
hPML/iso:3
Yes
organism-sequence
PR:P29590-4
transcription factor PML isoform 4 (human)
hPML/iso:4
Yes
organism-sequence
PR:P29590-5
transcription factor PML isoform 5 (human)
hPML/iso:5
Yes
organism-sequence
PR:P29590-8
protein PML isoform hPML-2 (human)
hPML/iso:hPML-2
organism-sequence
PR:P29590-9
protein PML isoform hPML-3 (human)
hPML/iso:hPML-3
organism-modification
PR:000064635
protein PML sumoylated 1 (human)
hPML/Sumo:1
organism-modification
PR:000076676
protein PML methylated 1 (human)
hPML/Me:1
organism-modification
PR:000079131
protein PML methylated 2 (human)
hPML/Me:2
organism-modification
PR:000080018
protein PML cysteinylated 1 (human)
hPML/Cyst:1
organism-modification
PR:000082789
protein PML cysteinylated 2 (human)
hPML/Cyst:2
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000026480
hPML/iso:1/Phos:1
UniProtKB:P29590-1, Ser-403, MOD:00046|Thr-409, MOD:00047
located_in
GO:0005634
nucleus
PMID:20832753
PR:P29590-1
hPML/iso:1
enables
GO:0005515
protein binding
with
PR:Q13164
Big MAP kinase 1 (human)
PMID:20832753
located_in
GO:0005634
nucleus
PMID:16778193
GO:0005737
cytoplasm
PMID:9885291
GO:0005737
cytoplasm
PMID:9885291
PR:P29590-2
hPML/iso:2
acts_upstream_of_or_within
GO:0002230
positive regulation of defense response to virus by host
PMID:16873256
located_in
GO:0005634
nucleus
PMID:16778193
GO:0005737
cytoplasm
PMID:16778193
PR:P29590-3
hPML/iso:3
acts_upstream_of_or_within
GO:0006915
apoptotic process
PMID:9583681
GO:0030308
negative regulation of cell growth
PMID:9583681
GO:0030308
negative regulation of cell growth
PMID:9583681
GO:0030308
negative regulation of cell growth
PMID:9583681
GO:0030578
PML body organization
PMID:10779416
GO:0045930
negative regulation of mitotic cell cycle
PMID:9395203
GO:0051726
regulation of cell cycle
PMID:9583681
enables
GO:0005515
protein binding
with
PR:P04489
E4orf3
PMID:10610177
GO:0005515
protein binding
with
PR:P06400
hRB1
PMID:10610177
GO:0005515
protein binding
with
PR:P45481
Cbp
PMID:10610177
GO:0005515
protein binding
with
PR:Q64127
E3 ubiquitin-protein ligase Trim24 (mouse)
PMID:10610177
GO:0046982
protein heterodimerization activity
PMID:7935403
located_in
GO:0005634
nucleus
PMID:9294197
GO:0005737
cytoplasm
PMID:16778193
GO:0031965
nuclear membrane
PMID:16778193
PR:P29590-4
hPML/iso:4
acts_upstream_of_or_within
GO:0002230
positive regulation of defense response to virus by host
PMID:16873257
GO:0030578
PML body organization
PMID:8643677
enables
GO:0005515
protein binding
with
PR:P14373
hTRIM27
PMID:10669754
GO:0005515
protein binding
with
PR:P23769
GATA-binding protein 2 (human)
PMID:10669754
GO:0005515
protein binding
with
PR:P63073
eIF-4E (mouse)
PMID:10669754
GO:0005515
protein binding
with
PR:P63165
GAP-modifying protein 1 (human)
PMID:10669754
GO:0005515
protein binding
with
PR:P63279
hUBE2I
PMID:10669754
GO:0005515
protein binding
with
PR:Q03014
HEX
PMID:10669754
GO:0005515
protein binding
with
PR:Q9UER7-1
PMID:10669754
GO:0008270
zinc ion binding
PMID:7729428
GO:0050897
cobalt ion binding
PMID:7729428
located_in
GO:0016605
PML body
PMID:9885291
PR:P29590-5
hPML/iso:5
acts_upstream_of_or_within
GO:0006605
protein targeting
PMID:15195100
GO:0006605
protein targeting
PMID:15195100
GO:0006915
apoptotic process
PMID:11080164
GO:0008630
intrinsic apoptotic signaling pathway in response to DNA damage
PMID:12402044
GO:0030308
negative regulation of cell growth
PMID:9448006
GO:0032938
negative regulation of translation in response to oxidative stress
PMID:16915281
GO:0045892
negative regulation of DNA-templated transcription
PMID:9448006
GO:0050821
protein stabilization
PMID:12773567
GO:0051726
regulation of cell cycle
PMID:12773567
enables
GO:0003713
transcription coactivator activity
PMID:15626733
GO:0003713
transcription coactivator activity
PMID:15626733
GO:0005515
protein binding
with
PR:P04637
antigen NY-CO-13 (human)
PMID:11259576
GO:0005515
protein binding
with
PR:P06400
hRB1
PMID:11259576
GO:0005515
protein binding
with
PR:P62913
60S ribosomal protein L11 (human)
PMID:11259576
GO:0005515
protein binding
with
PR:Q00987
double minute 2 protein (human)
PMID:11259576
GO:0005515
protein binding
with
PR:Q00987
double minute 2 protein (human)
PMID:11259576
GO:0005515
protein binding
with
PR:Q05516
hZBTB16
PMID:11259576
GO:0005515
protein binding
with
PR:Q05516
hZBTB16
PMID:11259576
GO:0005515
protein binding
with
PR:Q13547
HD1 (human)
PMID:11259576
GO:0005515
protein binding
with
PR:Q92547
DNA topoisomerase II-beta-binding protein 1 (human)
PMID:11259576
GO:0005515
protein binding
with
PR:Q92769
HD2 (human)
PMID:11259576
GO:0005515
protein binding
PMID:11259576
GO:0005515
protein binding
PMID:11259576
located_in
GO:0005730
nucleolus
PMID:16778193
GO:0005737
cytoplasm
PMID:16778193
GO:0016363
nuclear matrix
PMID:11080164
GO:0016605
PML body
PMID:9448006