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Protein Ontology report - dual specificity protein kinase TTK (human)
PR:P33981 - http://purl.obolibrary.org/obo/PR_P33981
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P33981   
  PRO namedual specificity protein kinase TTK (human) 
  Synonyms
PRO-Short-label: EXACT:hTTK
Gene-based: RELATED:MPS1 | MPS1L1 | TTK
Other: EXACT:phosphotyrosine picked threonine-protein kinase (human) | PYT (human)
  Definition"A dual specificity protein kinase TTK that is encoded in the genome of human." [PMID:20823832, PRO:KER] 
  PRO Categoryorganism-gene 
  ParentPR:000016787 dual specificity protein kinase TTK
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:12401 TTK (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P33981
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
organism-gene


PR:P33981
dual specificity protein kinase TTK (human)
hTTK
"A dual specificity protein kinase TTK that is encoded in the genome of human." [PMID:20823832, PRO:KER]
Yes
organism-sequence


PR:P33981-1
dual specificity protein kinase TTK isoform h1 (human)
hTTK/iso:h1
"A dual specificity protein kinase TTK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P33981-1." [PRO:DNx, UniProtKB:P33981]

organism-sequence


PR:P33981-2
dual specificity protein kinase TTK isoform h2 (human)
hTTK/iso:h2
"A dual specificity protein kinase TTK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P33981-2." [PRO:DNx, UniProtKB:P33981]

organism-modification


PR:000045754
dual specificity protein kinase TTK phosphorylated 1 (human)
hTTK/Phos:1
"A dual specificity protein kinase TTK (human) that has been phosphorylated on the residue at the position equivalent to Thr-676 of the amino acid sequence represented by UniProtKB:P33981-1. Example: UniProtKB:P33981-1, Thr-676, MOD:00047." [iPTMnet:P33981, PMID:18083840, PMID:18680479, PMID:19120698, PRO:KER]
Yes
organism-modification


PR:000049844
TTK activation loop phosphorylated form (human)
hTTK/(Act-loop)Phos+
"A dual specificity protein kinase TTK (human) that has been phosphorylated on one of three sites within the activation loop, at positions equivalent to Thr-675 or Thr-676 or Ser-677 of the amino acid sequence represented by UniProtKB:P33981-1. Example: UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)." [PMID:17728254, PMID:18923149, PMID:19120698, PRO:KER]
Yes
organism-modification


PR:000049845
TTK activation loop and P+1 loop phosphorylated form (human)
hTTK/(Act-loop_P+1-loop)Phos+
"A dual specificity protein kinase TTK (human) that has been phosphorylated on one of three sites within the activation loop and on a Thr residue in the P+1 loop. Example: UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)|Thr-686, MOD:00047." [PMID:19120698, PRO:KER]
Yes
organism-modification


PR:000083646
dual specificity protein kinase TTK methylated 1 (human)
hTTK/Me:1
"A dual specificity protein kinase TTK (human) that has been methylated on the residue at the position equivalent to Cys-517 of the amino acid sequence represented by UniProtKB:P33981-1. Example: UniProtKB:P33981-1, Cys-517, MOD:00660." [IEDB_epitope:1047616, PRO:DNx]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000045754 hTTK/Phos:1
Example: UniProtKB:P33981-1, Thr-676, MOD:00047		 acts_upstream_of_or_withinGO:0046777 protein autophosphorylation PMID:18680479; PMID:19120698
GO:0051298 centrosome duplication PMID:17728254
GO:0071174 mitotic spindle checkpoint signaling PMID:18083840
enablesGO:0004672 protein kinase activity PMID:18680479
PR:000049844 hTTK/(Act-loop)Phos+
Example: UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)		 acts_upstream_of_or_withinGO:0046777 protein autophosphorylation PMID:18680479; PMID:19120698
enablesGO:0004672 protein kinase activity PMID:18680479; PMID:19120698
PR:000049845 hTTK/(Act-loop_P+1-loop)Phos+
Example: UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)|Thr-686, MOD:00047		 enablesGO:0004672 protein kinase activity PMID:19120698
PR:P33981 hTTK acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:20624902
GO:0032092 positive regulation of protein binding PMID:22660415
GO:0032092 positive regulation of protein binding PMID:22660415
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
GO:0045841 negative regulation of mitotic metaphase/anaphase transition PMID:20624902
GO:0051310 metaphase chromosome alignment PMID:20624902; PMID:22732840
enablesGO:0005515 protein binding with PR:Q12834 CDC20 BioGRID:BG-590746
located_inGO:0000776 kinetochore PMID:20624902