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Protein Ontology report - catenin beta-1 (human)
PR:P35222 - http://purl.obolibrary.org/obo/PR_P35222
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P35222   
  PRO namecatenin beta-1 (human) 
  Synonyms
PRO-Short-label: EXACT:hCTNNB1
Gene-based: RELATED:CTNNB | CTNNB1 | OK/SW-cl.35 | PRO2286
Other: EXACT:beta-catenin (human)
  Definition"A catenin beta-1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P35222] 
  PRO Categoryorganism-gene 
  ParentPR:000002198 catenin beta-1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:2514 CTNNB1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 7                                        
         Modification0                                                  Organism-Modification 61                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P35222
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
organism-gene


PR:P35222 catenin beta-1 (human)
hCTNNB1

organism-sequence


PR:000061264 catenin beta-1 sequence variant S45F (human)
hCTNNB1/var:S45F

organism-sequence


PR:000061660 catenin beta-1 sequence variant S45N (human)
hCTNNB1/var:S45N

organism-sequence


PR:000061754 catenin beta-1 sequence variant S45C (human)
hCTNNB1/var:S45C

organism-sequence


PR:000062114 catenin beta-1 sequence variant S45Y (human)
hCTNNB1/var:S45Y

organism-sequence


PR:000063541 catenin beta-1 sequence variant S45A (human)
hCTNNB1/var:S45A

organism-sequence


PR:000064561 catenin beta-1 sequence variant S45P (human)
hCTNNB1/var:S45P

organism-sequence


PR:P35222-1 catenin beta-1 isoform 1 (human)
hCTNNB1/iso:1

organism-modification


PR:000028553 catenin beta-1 isoform 1 acetylated 1 (human)
hCTNNB1/iso:1/Ac:1

organism-modification


PR:000028794 catenin beta-1 isoform 1 acetylated 2 (human)
hCTNNB1/iso:1/Ac:2

organism-modification


PR:000030192 catenin beta-1 isoform 1 phosphorylated 1 (human)
hCTNNB1/iso:1/Phos:1
Yes
organism-modification


PR:000035770 catenin beta-1 isoform 1 phosphorylated 2 (human)
hCTNNB1/iso:1/Phos:2
Yes
organism-modification


PR:000035772 catenin beta-1 isoform 1 phosphorylated 3 (human)
hCTNNB1/iso:1/Phos:3
Yes
organism-modification


PR:000035774 catenin beta-1 isoform 1 phosphorylated 4 (human)
hCTNNB1/iso:1/Phos:4
Yes
organism-modification


PR:000036862 catenin beta-1 isoform 1 phosphorylated 5 (human)
hCTNNB1/iso:1/Phos:5
Yes
organism-modification


PR:000036872 catenin beta-1 isoform 1 unphosphorylated 1 (human)
hCTNNB1/iso:1/UnPhos:1

organism-modification


PR:000037181 catenin beta-1 isoform 1 phosphorylated 6 (human)
hCTNNB1/iso:1/Phos:6
Yes
organism-modification


PR:000037185 catenin beta-1 isoform 1 unphosphorylated 2 (human)
hCTNNB1/iso:1/UnPhos:2
Yes
organism-modification


PR:000037190 catenin beta-1 isoform 1 phosphorylated 7 (human)
hCTNNB1/iso:1/Phos:7
Yes
organism-modification


PR:000037192 catenin beta-1 isoform 1 phosphorylated 8 (human)
hCTNNB1/iso:1/Phos:8
Yes
organism-modification


PR:000037194 catenin beta-1 isoform 1 phosphorylated 9 (human)
hCTNNB1/iso:1/Phos:9
Yes
organism-modification


PR:000037196 catenin beta-1 isoform 1 unphosphorylated 3 (human)
hCTNNB1/iso:1/UnPhos:3

organism-modification


PR:000037229 catenin beta-1 isoform 1 phosphorylated 10 (human)
hCTNNB1/iso:1/Phos:10

organism-modification


PR:000037515 catenin beta-1 isoform 1 phosphorylated 11 (human)
hCTNNB1/iso:1/Phos:11
Yes
organism-modification


PR:000037772 catenin beta-1 isoform 1 unphosphorylated 4 (human)
hCTNNB1/iso:1/UnPhos:4

organism-modification


PR:000037811 catenin beta-1 isoform 1 unphosphorylated 5 (human)
hCTNNB1/iso:1/UnPhos:5

organism-modification


PR:000037813 catenin beta-1 isoform 1 unphosphorylated 6 (human)
hCTNNB1/iso:1/UnPhos:6

organism-modification


PR:000044474 catenin beta-1 isoform 1 phosphorylated 12 (human)
hCTNNB1/iso:1/Phos:12
Yes
organism-modification


PR:000044476 catenin beta-1 isoform 1 unphosphorylated 7 (human)
hCTNNB1/iso:1/UnPhos:7
Yes
organism-modification


PR:000044478 catenin beta-1 isoform 1 phosphorylated 13 (human)
hCTNNB1/iso:1/Phos:13
Yes
organism-modification


PR:000044510 catenin beta-1 isoform 1 phosphorylated 14 (human)
hCTNNB1/iso:1/Phos:14
Yes
organism-modification


PR:000045759 catenin beta-1 phosphorylated 1 (human)
hCTNNB1/Phos:1

organism-modification


PR:000047098 catenin beta-1 phosphorylated 14 (human)
hCTNNB1/Phos:14

organism-modification


PR:000060682 catenin beta-1 phosphorylated 2 (human)
hCTNNB1/Phos:2

organism-modification


PR:000061388 catenin beta-1 phosphorylated 3 (human)
hCTNNB1/Phos:3

organism-modification


PR:000061828 catenin beta-1 sequence variant S33T phosphorylated 1 (human)
hCTNNB1/var:S33T/Phos:1

organism-modification


PR:000062018 catenin beta-1 phosphorylated 4 (human)
hCTNNB1/Phos:4

organism-modification


PR:000062261 catenin beta-1 sequence variant S33Y phosphorylated 1 (human)
hCTNNB1/var:S33Y/Phos:1

organism-modification


PR:000062660 catenin beta-1 sequence variant T41A phosphorylated 1 (human)
hCTNNB1/var:T41A/Phos:1

organism-modification


PR:000063106 catenin beta-1 sequence variant S33P phosphorylated 1 (human)
hCTNNB1/var:S33P/Phos:1

organism-modification


PR:000063242 catenin beta-1 phosphorylated 5 (human)
hCTNNB1/Phos:5

organism-modification


PR:000063450 catenin beta-1 sequence variant S37C phosphorylated 1 (human)
hCTNNB1/var:S37C/Phos:1

organism-modification


PR:000063474 catenin beta-1 sequence variant T41N phosphorylated 1 (human)
hCTNNB1/var:T41N/Phos:1

organism-modification


PR:000063642 catenin beta-1 phosphotyrosine form (human)
hCTNNB1/PhosTyr+

organism-modification


PR:000063679 catenin beta-1 sequence variant S37F phosphorylated 1 (human)
hCTNNB1/var:S37F/Phos:1

organism-modification


PR:000063722 catenin beta-1 sequence variant S37P phosphorylated 1 (human)
hCTNNB1/var:S37P/Phos:1

organism-modification


PR:000063730 catenin beta-1 sequence variant S33A phosphorylated 1 (human)
hCTNNB1/var:S33A/Phos:1

organism-modification


PR:000064007 catenin beta-1 sequence variant S33F phosphorylated 1 (human)
hCTNNB1/var:S33F/Phos:1

organism-modification


PR:000064514 catenin beta-1 sequence variant S37A phosphorylated 1 (human)
hCTNNB1/var:S37A/Phos:1

organism-modification


PR:000064522 catenin beta-1 sequence variant T41I phosphorylated 1 (human)
hCTNNB1/var:T41I/Phos:1

organism-modification


PR:000064617 catenin beta-1 sequence variant S37Y phosphorylated 1 (human)
hCTNNB1/var:S37Y/Phos:1

organism-modification


PR:000064630 catenin beta-1 sequence variant S33C phosphorylated 1 (human)
hCTNNB1/var:S33C/Phos:1

organism-modification


PR:000064687 catenin beta-1 phosphotyrosine and ubiquitinated form (human)
hCTNNB1/pTyrUbiq+

organism-modification


PR:000066779 catenin beta-1 deaminated 1 (human)
hCTNNB1/Deam:1

organism-modification


PR:000067750 catenin beta-1 hydroxylated 1 (human)
hCTNNB1/Hy:1

organism-modification


PR:000068617 catenin beta-1 deaminated 2 (human)
hCTNNB1/Deam:2

organism-modification


PR:000069742 catenin beta-1 methylated 1 (human)
hCTNNB1/Me:1

organism-modification


PR:000070600 catenin beta-1 deaminated 3 (human)
hCTNNB1/Deam:3

organism-modification


PR:000070619 catenin beta-1 phosphorylated 6 (human)
hCTNNB1/Phos:6

organism-modification


PR:000072104 catenin beta-1 deaminated 4 (human)
hCTNNB1/Deam:4

organism-modification


PR:000073018 catenin beta-1 deaminated 5 (human)
hCTNNB1/Deam:5

organism-modification


PR:000074709 catenin beta-1 phosphorylated 7 (human)
hCTNNB1/Phos:7

organism-modification


PR:000077754 catenin beta-1 methylated 2 (human)
hCTNNB1/Me:2

organism-modification


PR:000078916 catenin beta-1 deaminated 6 (human)
hCTNNB1/Deam:6

organism-modification


PR:000079374 catenin beta-1 deaminated 7 (human)
hCTNNB1/Deam:7

organism-modification


PR:000079462 catenin beta-1 cysteinylated 1 (human)
hCTNNB1/Cyst:1

organism-modification


PR:000081820 catenin beta-1 deaminated 8 (human)
hCTNNB1/Deam:8

organism-modification


PR:000082238 catenin beta-1 methylated 3 (human)
hCTNNB1/Me:3

organism-modification


PR:000083454 catenin beta-1 cysteinylated 2 (human)
hCTNNB1/Cyst:2

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000030192 hCTNNB1/iso:1/Phos:1
UniProtKB:P35222-1, Ser-663/Ser-675, MOD:00046		 acts_upstream_of_or_withinGO:0016055 Wnt signaling pathway PMID:22369945
enablesincreased GO:0003713 transcription coactivator activity relative to PR:000002862 CTNNB1/iso:1/UnMod PMID:22369945
PR:000035770 hCTNNB1/iso:1/Phos:2
UniProtKB:P35222-1, Tyr-64, MOD:00048|Tyr-142, MOD:00048|(Tyr-331, MOD:00048 or Tyr-333, MOD:00048)		 located_inGO:0005634 nucleus PMID:20026641
PR:000035772 hCTNNB1/iso:1/Phos:3
UniProtKB:P35222-1, Ser-33/Ser-37/Ser-45, MOD:00046|Thr-41, MOD:00047		 enablesNOT GO:0005515 protein binding with PR:Q9Y297 BTRC PMID:10074433
NOT GO:0005515 protein binding with PR:Q9UKB1 BTRCP2 PMID:10074433
PR:000035774 hCTNNB1/iso:1/Phos:4
UniProtKB:P35222-1, Ser-45, MOD:00046		 enablesincreased GO:0005515 protein binding with PR:P12830 CAM 120/80 (human) PMID:12051714; PMID:20419129; PMID:23606879
increased GO:0005515 protein binding with PR:P49841 GSK-3 beta (human) PMID:12051714; PMID:20419129; PMID:23606879
located_inGO:0005634 nucleus PMID:20419129
PR:000036862 hCTNNB1/iso:1/Phos:5
UniProtKB:P35222-1, Ser-552/Ser-675, MOD:00046		 enablesincreased GO:0003713 transcription coactivator activity relative to PR:000036872 hCTNNB1/iso:1/UnPhos:1 PMID:16476742
increased GO:0005515 protein binding relative to PR:000036872 hCTNNB1/iso:1/UnPhos:1 PMID:16476742
PR:000037181 hCTNNB1/iso:1/Phos:6
UniProtKB:P35222-1, Ser-37, MOD:00046|Thr-41, MOD:00047		 located_indecreased GO:0005912 adherens junction relative to PR:000037185 hCTNNB1/iso:1/UnPhos:2 PMID:19667122
PR:000037185 hCTNNB1/iso:1/UnPhos:2
UniProtKB:P35222-1, Ser-37/Thr-41, PR:000026291		 enablesGO:0003713 transcription coactivator activity PMID:20419129
GO:0005515 protein binding PMID:20419129
located_inGO:0005634 nucleus PMID:20419129
PR:000037190 hCTNNB1/iso:1/Phos:7
UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047		 acts_upstream_of_or_withindecreased GO:0007155 cell adhesion relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 PMID:19667122
GO:0010631 epithelial cell migration PMID:21152425
decreased GO:0034333 adherens junction assembly relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 PMID:19667122
enablesdecreased GO:0003713 transcription coactivator activity relative to PR:000037185 hCTNNB1/iso:1/UnPhos:2 PMID:20419129
NOT GO:0005515 protein binding with PR:Q9HCS4 HMG box transcription factor 3 (human) PMID:21152425
NOT GO:0005515 protein binding with PR:Q9NQB0 HMG box transcription factor 4 (human) PMID:21152425
NOT GO:0005515 protein binding with PR:Q9UJU2 hLEF1 PMID:21152425
NOT GO:0005515 protein binding with PR:Q9Y297 BTRC PMID:21152425
NOT GO:0005515 protein binding with PR:P12830 CAM 120/80 (human) PMID:21152425
NOT GO:0005515 protein binding PMID:21152425
located_inGO:0005737 cytoplasm PMID:20419129
decreased GO:0005912 adherens junction relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 PMID:19667122
PR:000037192 hCTNNB1/iso:1/Phos:8
UniProtKB:P35222-1, Tyr-333, MOD:00048		 acts_upstream_of_or_withinGO:0007173 epidermal growth factor receptor signaling pathway PMID:22056988
enablesGO:0003713 transcription coactivator activity PMID:22056988
GO:0005515 protein binding PMID:22056988
located_inGO:0005634 nucleus PMID:22056988
PR:000037194 hCTNNB1/iso:1/Phos:9
UniProtKB:P35222-1, Tyr-86/Tyr-654, MOD:00048		 enablesincreased GO:0017025 TBP-class protein binding with PR:P20226 GTF2D1 PMID:11279024
decreased GO:0045296 cadherin binding relative to PR:000037196 hCTNNB1/iso:1/UnPhos:3 PMID:11279024
PR:000037515 hCTNNB1/iso:1/Phos:11
UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046		 acts_upstream_of_or_withindecreased GO:0008283 cell population proliferation relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:20307497
decreased GO:0060070 canonical Wnt signaling pathway relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:20307497
enablesdecreased GO:0003713 transcription coactivator activity relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:20307497
increased GO:0005515 protein binding relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:16996060; PMID:21152425; PMID:23071615
PR:000044474 hCTNNB1/iso:1/Phos:12
UniProtKB:P35222-1, Thr-393, MOD:00047		 acts_upstream_of_or_withinGO:0016055 Wnt signaling pathway PMID:12700239
GO:0045944 positive regulation of transcription by RNA polymerase II PMID:12700239
enablesdecreased GO:0005515 protein binding with PR:Q9YGY0 axin PMID:19565571
PR:000044476 hCTNNB1/iso:1/UnPhos:7
UniProtKB:P35222-1, Thr-393, PR:000026291		 enablesGO:0005515 protein binding with PR:Q9YGY0 axin PMID:19565571
PR:000044478 hCTNNB1/iso:1/Phos:13
UniProtKB:P35222-1, Tyr-654, MOD:00048		 enablesGO:0003713 transcription coactivator activity PMID:23640056
PR:000044510 hCTNNB1/iso:1/Phos:14
UniProtKB:P35222-1, Ser-552, MOD:00046		 enablesGO:0071889 14-3-3 protein binding with PR:P63104 hYWHAZ PMID:17287208