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Protein Ontology report - bone morphogenetic protein receptor type-1A (human)
PR:P36894 -
http://purl.obolibrary.org/obo/PR_P36894
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:P36894
PRO name
bone morphogenetic protein receptor type-1A (human)
Synonyms
PRO-Short-label
:
EXACT:
hBMPR1A
Gene-based
:
RELATED:
ACVRLK3 | ALK3 | BMPR1A
Other
:
EXACT:
activin receptor-like kinase 3 (human) | ALK-3 (human) | BMP type-1A receptor (human) | BMPR-1A (human) | CD292 (human) | serine/threonine-protein kinase receptor R5 (human) | SKR5 (human)
Definition
"A BMP receptor type-1A that is encoded in the genome of human." [PRO:CNA,
UniProtKB:P36894
]
PRO Category
organism-gene
Parent
PR:000000035
BMP receptor type-1A
PR:000029067
Homo sapiens protein
Gene Template
HGNC:1076
BMPR1A (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
9
Modification
0
Organism-Modification
4
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:P36894
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
organism-gene
PR:P36894
bone morphogenetic protein receptor type-1A (human)
hBMPR1A
"A BMP receptor type-1A that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36894]
organism-sequence
PR:000000137
BMP receptor type-1A sequence variant Y62D (human)
hBMPR1A/var:Y62D
"A bone morphogenetic protein receptor type-1A (human) that has an Asp residue at the position equivalent to Tyr-62 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Tyr-62, CHEBI:29958." [PMID:12417513, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000138
BMP receptor type-1A sequence variant C82Y (human)
hBMPR1A/var:C82Y
"A bone morphogenetic protein receptor type-1A (human) that has a Tyr residue at the position equivalent to Cys-82 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-82, CHEBI:46858." [PMID:12417513, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000139
BMP receptor type-1A sequence variant C124R (human)
hBMPR1A/var:C124R
"A bone morphogenetic protein receptor type-1A (human) that has an Arg residue at the position equivalent to Cys-124 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-124, CHEBI:29952." [PMID:11536076, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000140
BMP receptor type-1A sequence variant C130R (human)
hBMPR1A/var:C130R
"A bone morphogenetic protein receptor type-1A (human) that has an Arg residue at the position equivalent to Cys-130 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-130, CHEBI:29952." [PMID:12136244, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000141
BMP receptor type-1A sequence variant A338D (human)
hBMPR1A/var:A338D
"A bone morphogenetic protein receptor type-1A (human) that has an Asp residue at the position equivalent to Ala-338 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Ala-338, CHEBI:29958." [PMID:11536076, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000142
BMP receptor type-1A sequence variant C376Y (human)
hBMPR1A/var:C376Y
"A bone morphogenetic protein receptor type-1A (human) that has a Tyr residue at the position equivalent to Cys-376 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-376, CHEBI:46858." [PMID:11536076, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000143
BMP receptor type-1A sequence variant R443C (human)
hBMPR1A/var:R443C
"A bone morphogenetic protein receptor type-1A (human) that has a Cys residue at the position equivalent to Arg-443 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Arg-443, CHEBI:29950." [PMID:12417513, PMID:17344846, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000144
BMP receptor type-1A sequence variant M470T (human)
hBMPR1A/var:M470T
"A bone morphogenetic protein receptor type-1A (human) that has a Thr residue at the position equivalent to Met-470 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Met-470, CHEBI:30013." [PMID:12630959, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:P36894-1
bone morphogenetic protein receptor type-1A isoform 1 (human)
hBMPR1A/iso:1
"A BMP receptor type-1A isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification
PR:000036422
BMP receptor type-1A isoform 1 phosphorylated 1 (human)
hBMPR1A/iso:1/Phos:1
"A BMP receptor type-1A isoform 1 phosphorylated 1 in human." [PMID:10712517, PMID:12065756, PMID:12829744, PMID:15940369, PRO:CNA]
Yes
organism-modification
PR:000036424
BMP receptor type-1A isoform 1 phosphorylated 2 (human)
hBMPR1A/iso:1/Phos:2
"A BMP receptor type-1A isoform 1 phosphorylated 2 in human. UniProtKB:P36894-1, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046." [PMID:17081983, PRO:CNA]
organism-modification
PR:000046493
bone morphogenetic protein receptor type-1A, signal peptide removed form (human)
hBMPR1A/SigPep-
"A bone morphogenetic protein receptor type-1A (human) that has had the signal peptide removed. UniProtKB:P36894, 24-532." [PRO:DNx, Reactome:R-HSA-201480]
organism-modification
PR:000046494
bone morphogenetic protein receptor type-1A, signal peptide removed phosphorylated 2 (human)
hBMPR1A/SigPep-/Phos:2
"A bone morphogenetic protein receptor type-1A (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at positions 215, 216, 218 and 220 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, 24-532, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046." [PRO:DNx, Reactome:R-HSA-201448]
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000137
hBMPR1A/var:Y62D
UniProtKB:P36894, Tyr-62, CHEBI:29958
associated_with_disease_progression
DO:0050787
juvenile polyposis syndrome
PMID:12417513
PR:000000138
hBMPR1A/var:C82Y
UniProtKB:P36894, Cys-82, CHEBI:46858
associated_with_disease_progression
DO:0050787
juvenile polyposis syndrome
PMID:12417513
PR:000000139
hBMPR1A/var:C124R
UniProtKB:P36894, Cys-124, CHEBI:29952
associated_with_disease_progression
DO:0050787
juvenile polyposis syndrome
PMID:11536076
PR:000000140
hBMPR1A/var:C130R
UniProtKB:P36894, Cys-130, CHEBI:29952
associated_with_disease_progression
DO:0050787
juvenile polyposis syndrome
PMID:12136244
PR:000000141
hBMPR1A/var:A338D
UniProtKB:P36894, Ala-338, CHEBI:29958
associated_with_disease_progression
DO:6457
Cowden syndrome
PMID:11536076
PR:000000142
hBMPR1A/var:C376Y
UniProtKB:P36894, Cys-376, CHEBI:46858
associated_with_disease_progression
DO:0050787
juvenile polyposis syndrome
PMID:11536076
PR:000000143
hBMPR1A/var:R443C
UniProtKB:P36894, Arg-443, CHEBI:29950
associated_with_disease_progression
DO:0050787
juvenile polyposis syndrome
PMID:12417513
;
PMID:17344846
PR:000000144
hBMPR1A/var:M470T
UniProtKB:P36894, Met-470, CHEBI:30013
associated_with_disease_progression
DO:0050787
juvenile polyposis syndrome
PMID:12630959
PR:000036422
hBMPR1A/iso:1/Phos:1
acts_upstream_of_or_within
GO:0006468
protein phosphorylation
PMID:12065756
GO:0030509
BMP signaling pathway
PMID:12829744
enables
GO:0004674
protein serine/threonine kinase activity
PMID:12829744
located_in
GO:0009986
cell surface
PMID:10712517
GO:0043235
receptor complex
PMID:12829744
;
PMID:15940369
PR:P36894-1
hBMPR1A/iso:1
located_in
GO:0016020
membrane
PMID:8397373
GO:0043235
receptor complex
PMID:15940369