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Protein Ontology report - TGF-beta receptor type-1 (human)
PR:P36897 -
http://purl.obolibrary.org/obo/PR_P36897
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:P36897
PRO name
TGF-beta receptor type-1 (human)
Synonyms
PRO-Short-label
:
EXACT:
hTGFBR1
Gene-based
:
RELATED:
ALK5 | SKR4 | TGFBR1
Other
:
EXACT:
activin A receptor type II-like protein kinase of 53kD (human) | activin receptor-like kinase 5 (human) | ALK-5 (human) | serine/threonine-protein kinase receptor R4 (human) | TbetaR-I (human) | TGF-beta receptor type I (human) | TGF-beta type I receptor (human) | TGFR-1 (human) | transforming growth factor-beta receptor type I (human)
Definition
"A TGF-beta receptor type-1 that is encoded in the genome of human." [PRO:CNA,
UniProtKB:P36897
]
PRO Category
organism-gene
Parent
PR:000000047
TGF-beta receptor type-1
PR:000029067
Homo sapiens protein
Gene Template
HGNC:11772
TGFBR1 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
14
Modification
0
Organism-Modification
14
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:P36897
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
organism-gene
PR:P36897
TGF-beta receptor type-1 (human)
hTGFBR1
"A TGF-beta receptor type-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36897]
organism-sequence
PR:000000186
TGF-beta receptor type-1 sequence variant T200I (human)
hTGFBR1/var:T200I
"A TGF-beta receptor type-1 (human) that has an Ile residue at the position equivalent to Thr-200 of the amino acid sequence represented by UniProtKB:P36897. UniProtKB:P36897, Thr-200, CHEBI:30009." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000187
TGF-beta receptor type-1 sequence variant 10 (human)
hTGFBR1/var:10
"A TGF-beta receptor type-1 (human) that has an insertion of an Ala residue at the position equivalent to Ala-26 of the amino acid sequence represented by UniProtKB:P36897." [PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000188
TGF-beta receptor type-1 sequence variant 11 (human)
hTGFBR1/var:11
"A TGF-beta receptor type-1 (human) that has a three-residue deletion at the position equivalent to region 24-26 of the amino acid sequence represented by UniProtKB:P36897-1. UniProtKB:P36897, 1-23, 27-503." [PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000189
TGF-beta receptor type-1 sequence variant K232E (human)
hTGFBR1/var:K232E
"A TGF-beta receptor type-1 (human) that has a Glu residue at the position equivalent to Lys-232 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Lys-232, CHEBI:29972." [PMID:16928994, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000190
TGF-beta receptor type-1 sequence variant S241L (human)
hTGFBR1/var:S241L
"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Ser-241, CHEBI:30006." [PMID:16596670, PMID:16791849, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000191
TGF-beta receptor type-1 sequence variant N267H (human)
hTGFBR1/var:N267H
"A TGF-beta receptor type-1 (human) that has a His residue at the position equivalent to Asn-267 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Asn-267, CHEBI:29979." [PMID:16791849, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000192
TGF-beta receptor type-1 sequence variant M318R (human)
hTGFBR1/var:M318R
"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Met-318 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Met-318, CHEBI:29952." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000193
TGF-beta receptor type-1 sequence variant D400G (human)
hTGFBR1/var:D400G
"A TGF-beta receptor type-1 (human) that has a Gly residue at the position equivalent to Asp-400 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Asp-400, CHEBI:29947." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000194
TGF-beta receptor type-1 sequence variant R487P (human)
hTGFBR1/var:R487P
"A TGF-beta receptor type-1 (human) that has a Pro residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:50342." [PMID:15731757, PMID:16928994, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000195
TGF-beta receptor type-1 sequence variant R487E (human)
hTGFBR1/var:R487E
"A TGF-beta receptor type-1 (human) that has a Glu residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:29972." [PMID:16791849, PMID:16928994, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000196
TGF-beta receptor type-1 sequence variant R487W (human)
hTGFBR1/var:R487W
"A TGF-beta receptor type-1 (human) that has a Trp residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:29954." [PMID:16928994, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:P36897-1
TGF-beta receptor type-1 isoform 1 (human)
hTGFBR1/iso:1
"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification
PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. Phosphorylation occurs by the action of active TGF-beta receptor type-2 within the GS-motifs. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-sequence
PR:P36897-2
TGF-beta receptor type-1 isoform h2 (human)
hTGFBR1/iso:h2
"A TGF-beta receptor type-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-2." [PRO:DNx, UniProtKB:P36897]
organism-sequence
PR:P36897-3
TGF-beta receptor type-1 isoform h3 (human)
hTGFBR1/iso:h3
"A TGF-beta receptor type-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-3." [PRO:DNx, UniProtKB:P36897]
organism-modification
PR:000049432
TGF-beta receptor type-1, signal peptide removed form (human)
hTGFBR1/SigPep-
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed. UniProtKB:P36897, 34-503." [PRO:DNx, Reactome:R-HSA-170839]
organism-modification
PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. Phosphorylation occurs by the action of active TGF-beta receptor type-2 within the GS-motifs. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification
PR:000049433
TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)
hTGFBR1/SigPep-/UbiqLys+
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461]
organism-modification
PR:000049433
TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)
hTGFBR1/SigPep-/UbiqLys+
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461]
organism-modification
PR:000060809
TGF-beta receptor type-1 sequence variant G52R, signal peptide removed form (human)
hTGFBR1/var:G52R/SigPep-
"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Gly-52 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Gly-52, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-3656368]
organism-modification
PR:000060890
TGF-beta receptor type-1 sequence variant R414*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:R414*/SigPep-/Phos:1
"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Arg-413 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-413, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656508]
organism-modification
PR:000061254
TGF-beta receptor type-1 sequence variant P83L, signal peptide removed form (human)
hTGFBR1/var:P83L/SigPep-
"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-3656341]
organism-modification
PR:000061891
TGF-beta receptor type-1 sequence variant P83S, signal peptide removed form (human)
hTGFBR1/var:P83S/SigPep-
"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656326]
organism-modification
PR:000063489
TGF-beta receptor type-1 sequence variant C41Y, signal peptide removed form (human)
hTGFBR1/var:C41Y/SigPep-
"A TGF-beta receptor type-1 (human) that has a Tyr residue at the position equivalent to Cys-41 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Cys-41, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-3656328]
organism-modification
PR:000063569
TGF-beta receptor type-1 sequence variant N45S, signal peptide removed form (human)
hTGFBR1/var:N45S/SigPep-
"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Asn-45 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Asn-45, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656348]
organism-modification
PR:000064307
TGF-beta receptor type-1 sequence variant W242*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:W242*/SigPep-/Phos:1
"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-241, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656504]
organism-modification
PR:000067321
TGF-beta receptor type-1 methylated 1 (human)
hTGFBR1/Me:1
"A TGF-beta receptor type-1 (human) that has been methylated on the residue at the position equivalent to Cys-474 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Cys-474, MOD:00660." [IEDB_epitope:1046772, PRO:DNx]
organism-modification
PR:000070298
TGF-beta receptor type-1 methylated 2 (human)
hTGFBR1/Me:2
"A TGF-beta receptor type-1 (human) that has been methylated on the residue at the position equivalent to Cys-461 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Cys-461, MOD:00660." [IEDB_epitope:1039294, PRO:DNx]
organism-modification
PR:000075184
TGF-beta receptor type-1 cysteinylated 1 (human)
hTGFBR1/Cyst:1
"A TGF-beta receptor type-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-71 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Cys-71, MOD:00765." [IEDB_epitope:2129187, IEDB_epitope:2129188, PRO:DNx]
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hTGFBR1
forms found in complexes
hTGFBR1
Component
Complexes
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
PR:000025961
transforming growth factor beta type I receptor homodimeric complex phosphorylated form (human)
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000186
hTGFBR1/var:T200I
UniProtKB:P36897, Thr-200, CHEBI:30009
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000187
hTGFBR1/var:10
located_in
SO:0001605
amino_acid_insertion
PMID:9661882
PR:000000188
hTGFBR1/var:11
UniProtKB:P36897, 1-23, 27-503
acts_upstream_of_or_within
GO:0007165
signal transduction
PMID:9661882
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:9661882
PR:000000189
hTGFBR1/var:K232E
Example: UniProtKB:P36897-1, Lys-232, CHEBI:29972
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:16928994
PR:000000190
hTGFBR1/var:S241L
Example: UniProtKB:P36897-1, Ser-241, CHEBI:30006
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:16596670
;
PMID:16791849
PR:000000191
hTGFBR1/var:N267H
Example: UniProtKB:P36897-1, Asn-267, CHEBI:29979
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:16791849
PR:000000192
hTGFBR1/var:M318R
Example: UniProtKB:P36897-1, Met-318, CHEBI:29952
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000193
hTGFBR1/var:D400G
Example: UniProtKB:P36897-1, Asp-400, CHEBI:29947
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000194
hTGFBR1/var:R487P
Example: UniProtKB:P36897-1, Arg-487, CHEBI:50342
associated_with_disease_progression
DO:14756
vascular type Ehlers-Danlos syndrome
PMID:15731757
;
PMID:16928994
PR:000000195
hTGFBR1/var:R487E
Example: UniProtKB:P36897-1, Arg-487, CHEBI:29972
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:16791849
;
PMID:16928994
PR:000000196
hTGFBR1/var:R487W
Example: UniProtKB:P36897-1, Arg-487, CHEBI:29954
associated_with_disease_progression
DO:14756
vascular type Ehlers-Danlos syndrome
PMID:16928994
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
acts_upstream_of_or_within
GO:0006468
protein phosphorylation
PMID:7774578
GO:0007165
signal transduction
PMID:8242743
GO:0007181
transforming growth factor beta receptor complex assembly
PMID:8947046
enables
GO:0005025
transforming growth factor beta receptor activity, type I
PMID:7774578
;
PMID:8947046
located_in
GO:0005886
plasma membrane
PMID:8947046
PR:000036432
hTGFBR1/iso:1/SigPep-
UniProtKB:P36897-1, 34-503
acts_upstream_of_or_within
GO:0007165
signal transduction
PMID:8242743
GO:0007181
transforming growth factor beta receptor complex assembly
PMID:8242743
located_in
GO:0005886
plasma membrane
PMID:8242743
PR:P36897-1
hTGFBR1/iso:1
acts_upstream_of_or_within
GO:0007165
signal transduction
PMID:8242743
