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Protein Ontology report - TGF-beta receptor type-1 (human)
PR:P36897 - http://purl.obolibrary.org/obo/PR_P36897
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P36897   
  PRO nameTGF-beta receptor type-1 (human) 
  Synonyms
PRO-Short-label: EXACT:hTGFBR1
Gene-based: RELATED:ALK5 | SKR4 | TGFBR1
Other: EXACT:activin A receptor type II-like protein kinase of 53kD (human) | activin receptor-like kinase 5 (human) | ALK-5 (human) | serine/threonine-protein kinase receptor R4 (human) | TbetaR-I (human) | TGF-beta receptor type I (human) | TGF-beta type I receptor (human) | TGFR-1 (human) | transforming growth factor-beta receptor type I (human)
  Definition"A TGF-beta receptor type-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36897
  PRO Categoryorganism-gene 
  ParentPR:000000047 TGF-beta receptor type-1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:11772 TGFBR1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 14                                        
         Modification0                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P36897
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
organism-gene



PR:P36897

TGF-beta receptor type-1 (human)

hTGFBR1


"A TGF-beta receptor type-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36897]


organism-sequence



PR:000000186

TGF-beta receptor type-1 sequence variant T200I (human)

hTGFBR1/var:T200I


"A TGF-beta receptor type-1 (human) that has an Ile residue at the position equivalent to Thr-200 of the amino acid sequence represented by UniProtKB:P36897. UniProtKB:P36897, Thr-200, CHEBI:30009." [PMID:15731757, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000187

TGF-beta receptor type-1 sequence variant 10 (human)

hTGFBR1/var:10


"A TGF-beta receptor type-1 (human) that has an insertion of an Ala residue at the position equivalent to Ala-26 of the amino acid sequence represented by UniProtKB:P36897." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000188

TGF-beta receptor type-1 sequence variant 11 (human)

hTGFBR1/var:11


"A TGF-beta receptor type-1 (human) that has a three-residue deletion at the position equivalent to region 24-26 of the amino acid sequence represented by UniProtKB:P36897-1. UniProtKB:P36897, 1-23, 27-503." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000189

TGF-beta receptor type-1 sequence variant K232E (human)

hTGFBR1/var:K232E


"A TGF-beta receptor type-1 (human) that has a Glu residue at the position equivalent to Lys-232 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Lys-232, CHEBI:29972." [PMID:16928994, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000190

TGF-beta receptor type-1 sequence variant S241L (human)

hTGFBR1/var:S241L


"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Ser-241, CHEBI:30006." [PMID:16596670, PMID:16791849, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000191

TGF-beta receptor type-1 sequence variant N267H (human)

hTGFBR1/var:N267H


"A TGF-beta receptor type-1 (human) that has a His residue at the position equivalent to Asn-267 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Asn-267, CHEBI:29979." [PMID:16791849, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000192

TGF-beta receptor type-1 sequence variant M318R (human)

hTGFBR1/var:M318R


"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Met-318 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Met-318, CHEBI:29952." [PMID:15731757, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000193

TGF-beta receptor type-1 sequence variant D400G (human)

hTGFBR1/var:D400G


"A TGF-beta receptor type-1 (human) that has a Gly residue at the position equivalent to Asp-400 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Asp-400, CHEBI:29947." [PMID:15731757, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000194

TGF-beta receptor type-1 sequence variant R487P (human)

hTGFBR1/var:R487P


"A TGF-beta receptor type-1 (human) that has a Pro residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:50342." [PMID:15731757, PMID:16928994, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000195

TGF-beta receptor type-1 sequence variant R487E (human)

hTGFBR1/var:R487E


"A TGF-beta receptor type-1 (human) that has a Glu residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:29972." [PMID:16791849, PMID:16928994, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000196

TGF-beta receptor type-1 sequence variant R487W (human)

hTGFBR1/var:R487W


"A TGF-beta receptor type-1 (human) that has a Trp residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:29954." [PMID:16928994, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P36897-1

TGF-beta receptor type-1 isoform 1 (human)

hTGFBR1/iso:1


"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036432

TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)

hTGFBR1/iso:1/SigPep-


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]

Yes

organism-modification



PR:000025959

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. Phosphorylation occurs by the action of active TGF-beta receptor type-2 within the GS-motifs. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]

Yes

Yes
organism-sequence



PR:P36897-2

TGF-beta receptor type-1 isoform h2 (human)

hTGFBR1/iso:h2


"A TGF-beta receptor type-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-2." [PRO:DNx, UniProtKB:P36897]


organism-sequence



PR:P36897-3

TGF-beta receptor type-1 isoform h3 (human)

hTGFBR1/iso:h3


"A TGF-beta receptor type-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-3." [PRO:DNx, UniProtKB:P36897]


organism-modification



PR:000049432

TGF-beta receptor type-1, signal peptide removed form (human)

hTGFBR1/SigPep-


"A TGF-beta receptor type-1 (human) that has had the signal peptide removed. UniProtKB:P36897, 34-503." [PRO:DNx, Reactome:R-HSA-170839]


organism-modification



PR:000036432

TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)

hTGFBR1/iso:1/SigPep-


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]

Yes

organism-modification



PR:000025959

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. Phosphorylation occurs by the action of active TGF-beta receptor type-2 within the GS-motifs. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]

Yes

Yes
organism-modification



PR:000049433

TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)

hTGFBR1/SigPep-/UbiqLys+


"A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461]


organism-modification



PR:000049433

TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)

hTGFBR1/SigPep-/UbiqLys+


"A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461]


organism-modification



PR:000060809

TGF-beta receptor type-1 sequence variant G52R, signal peptide removed form (human)

hTGFBR1/var:G52R/SigPep-


"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Gly-52 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Gly-52, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-3656368]


organism-modification



PR:000060890

TGF-beta receptor type-1 sequence variant R414*, signal peptide removed phosphorylated 1 (human)

hTGFBR1/var:R414*/SigPep-/Phos:1


"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Arg-413 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-413, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656508]


organism-modification



PR:000061254

TGF-beta receptor type-1 sequence variant P83L, signal peptide removed form (human)

hTGFBR1/var:P83L/SigPep-


"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-3656341]


organism-modification



PR:000061891

TGF-beta receptor type-1 sequence variant P83S, signal peptide removed form (human)

hTGFBR1/var:P83S/SigPep-


"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656326]


organism-modification



PR:000063489

TGF-beta receptor type-1 sequence variant C41Y, signal peptide removed form (human)

hTGFBR1/var:C41Y/SigPep-


"A TGF-beta receptor type-1 (human) that has a Tyr residue at the position equivalent to Cys-41 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Cys-41, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-3656328]


organism-modification



PR:000063569

TGF-beta receptor type-1 sequence variant N45S, signal peptide removed form (human)

hTGFBR1/var:N45S/SigPep-


"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Asn-45 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Asn-45, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656348]


organism-modification



PR:000064307

TGF-beta receptor type-1 sequence variant W242*, signal peptide removed phosphorylated 1 (human)

hTGFBR1/var:W242*/SigPep-/Phos:1


"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-241, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656504]


organism-modification



PR:000067321

TGF-beta receptor type-1 methylated 1 (human)

hTGFBR1/Me:1


"A TGF-beta receptor type-1 (human) that has been methylated on the residue at the position equivalent to Cys-474 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Cys-474, MOD:00660." [IEDB_epitope:1046772, PRO:DNx]


organism-modification



PR:000070298

TGF-beta receptor type-1 methylated 2 (human)

hTGFBR1/Me:2


"A TGF-beta receptor type-1 (human) that has been methylated on the residue at the position equivalent to Cys-461 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Cys-461, MOD:00660." [IEDB_epitope:1039294, PRO:DNx]


organism-modification



PR:000075184

TGF-beta receptor type-1 cysteinylated 1 (human)

hTGFBR1/Cyst:1


"A TGF-beta receptor type-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-71 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Cys-71, MOD:00765." [IEDB_epitope:2129187, IEDB_epitope:2129188, PRO:DNx]


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hTGFBR1 forms found in complexes   

hTGFBR1 Component
Complexes
PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PR:000025961 transforming growth factor beta type I receptor homodimeric complex phosphorylated form (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006468 protein phosphorylationPR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:7774578
GO:0007165 signal transductionPR:000000188 hTGFBR1/var:11 PMID:9661882
PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:8242743
PR:000036432 hTGFBR1/iso:1/SigPep- PMID:8242743
PR:P36897-1 hTGFBR1/iso:1 PMID:8242743
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000000188 hTGFBR1/var:11 PMID:9661882
GO:0007181 transforming growth factor beta receptor complex assemblyPR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:8947046
PR:000036432 hTGFBR1/iso:1/SigPep- PMID:8242743

Disease Associated GO Term

Protein Forms & Complexes

Evidence
DO:0050466 Loeys-Dietz syndromePR:000000186 hTGFBR1/var:T200I PMID:15731757
PR:000000189 hTGFBR1/var:K232E PMID:16928994
PR:000000190 hTGFBR1/var:S241L PMID:16596670; PMID:16791849
PR:000000191 hTGFBR1/var:N267H PMID:16791849
PR:000000192 hTGFBR1/var:M318R PMID:15731757
PR:000000193 hTGFBR1/var:D400G PMID:15731757
PR:000000195 hTGFBR1/var:R487E PMID:16791849; PMID:16928994
DO:14756 vascular type Ehlers-Danlos syndromePR:000000194 hTGFBR1/var:R487P PMID:15731757; PMID:16928994
PR:000000196 hTGFBR1/var:R487W PMID:16928994

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005025 transforming growth factor beta receptor activity, type IPR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:7774578; PMID:8947046

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005886 plasma membranePR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:8947046
PR:000036432 hTGFBR1/iso:1/SigPep- PMID:8242743
SO:0001605 amino_acid_insertionPR:000000187 hTGFBR1/var:10 PMID:9661882