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RACE-PRO
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Documentation
Protein Ontology report - growth/differentiation factor 5 (human)
PR:P43026 -
http://purl.obolibrary.org/obo/PR_P43026
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:P43026
PRO name
growth/differentiation factor 5 (human)
Synonyms
PRO-Short-label
:
EXACT:
hGDF5
Gene-based
:
RELATED:
BMP14 | CDMP1 | GDF5
Other
:
EXACT:
BMP-14 (human) | bone morphogenetic protein 14 (human) | cartilage-derived morphogenetic protein 1 (human) | CDMP-1 (human) | GDF-5 (human) | LAP-4 (human) | lipopolysaccharide-associated protein 4 (human) | LPS-associated protein 4 (human) | radotermin (human)
Definition
"A growth/differentiation factor 5 that is encoded in the genome of human." [PRO:CNA,
UniProtKB:P43026
]
PRO Category
organism-gene
Parent
PR:000000281
growth/differentiation factor 5
PR:000029067
Homo sapiens protein
Gene Template
HGNC:4220
GDF5 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
4
Modification
0
Organism-Modification
2
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:P43026
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
comp.
In Complex?
organism-gene
PR:P43026
growth/differentiation factor 5 (human)
hGDF5
organism-sequence
PR:000000437
growth/differentiation factor 5 sequence variant C400Y (human)
hGDF5/var:C400Y
Yes
organism-sequence
PR:000000438
growth/differentiation factor 5 sequence variant R438L (human)
hGDF5/var:R438L
Yes
organism-sequence
PR:000000439
growth/differentiation factor 5 sequence variant L441P (human)
hGDF5/var:L441P
Yes
organism-sequence
PR:P43026-1
growth/differentiation factor 5 isoform 1 (human)
hGDF5/iso:1
Yes
organism-modification
PR:000036543
growth/differentiation factor 5 isoform 1 cleaved 1 (human)
hGDF5/iso:1/Clv:1
Yes
organism-modification
PR:000047523
growth/differentiation factor 5, signal peptide removed form (human)
hGDF5/SigPep-
organism-modification
PR:000036543
growth/differentiation factor 5 isoform 1 cleaved 1 (human)
hGDF5/iso:1/Clv:1
Yes
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000437
hGDF5/var:C400Y
UniProtKB:P43026, Cys-400, CHEBI:46858
associated_with_disease_progression
DO:0080052
acromesomelic dysplasia, Grebe type
UniProtKB_VAR:VAR_017407
enables
GO:0005515
protein binding
with
PR:000000164
BMP-2
PMID:9288098
NOT
GO:0008083
growth factor activity
PMID:9288098
located_in
GO:0005622
intracellular anatomical structure
PMID:9288098
PR:000000438
hGDF5/var:R438L
UniProtKB:P43026, Arg-438, CHEBI:30006
associated_with_disease_progression
DO:0050794
multiple synostoses syndrome
PMID:16532400
located_in
GO:0005615
extracellular space
PMID:16532400
PR:000000439
hGDF5/var:L441P
UniProtKB:P43026, Leu-441, CHEBI:50342
associated_with_disease_progression
DO:0050790
fibular hypoplasia and complex brachydactyly
UniProtKB_VAR:VAR_017408
PR:000036543
hGDF5/iso:1/Clv:1
UniProtKB:P43026-1, 382-501
enables
GO:0005102
signaling receptor binding
PMID:15752764
;
PMID:15890363
GO:0005515
protein binding
PMID:9288098
GO:0008083
growth factor activity
PMID:8589725
GO:0042803
protein homodimerization activity
PMID:15752764
;
PMID:8962721
located_in
GO:0005615
extracellular space
PMID:16532400
PR:P43026-1
hGDF5/iso:1
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:7961761
GO:0007267
cell-cell signaling
PMID:8589725
