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Protein Ontology report - glutamate--cysteine ligase catalytic subunit (human)
PR:P48506 - http://purl.obolibrary.org/obo/PR_P48506
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P48506   
  PRO nameglutamate--cysteine ligase catalytic subunit (human) 
  Synonyms
PRO-Short-label: EXACT:hGCLC
Gene-based: RELATED:GCLC | GLCL | GLCLC
Other: EXACT:gamma-ECS (human) | gamma-glutamylcysteine synthetase (human) | GCS heavy chain (human)
  Definition"A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of human." [PRO:DNx] 
  PRO Categoryorganism-gene 
  ParentPR:000007897 glutamate--cysteine ligase catalytic subunit
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:4311 GCLC (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P48506
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
organism-gene


PR:P48506
glutamate--cysteine ligase catalytic subunit (human)
hGCLC
"A glutamate--cysteine ligase catalytic subunit that is encoded in the genome of human." [PRO:DNx]

Yes
organism-sequence


PR:000060326
glutamate--cysteine ligase catalytic subunit sequence variant R127C (human)
hGCLC/var:R127C
"A glutamate--cysteine ligase catalytic subunit (human) that has a Cys residue at the position equivalent to Arg-127 of the amino acid sequence represented by UniProtKB:P48506. UniProtKB:P48506, Arg-127, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-5602822]

organism-sequence


PR:000061222
glutamate--cysteine ligase catalytic subunit sequence variant H370L (human)
hGCLC/var:H370L
"A glutamate--cysteine ligase catalytic subunit (human) that has a Leu residue at the position equivalent to His-370 of the amino acid sequence represented by UniProtKB:P48506. UniProtKB:P48506, His-370, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-5602842]

organism-sequence


PR:000062472
glutamate--cysteine ligase catalytic subunit sequence variant P158L (human)
hGCLC/var:P158L
"A glutamate--cysteine ligase catalytic subunit (human) that has a Leu residue at the position equivalent to Pro-158 of the amino acid sequence represented by UniProtKB:P48506. UniProtKB:P48506, Pro-158, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-5602975]

organism-sequence


PR:P48506-1
glutamate--cysteine ligase catalytic subunit isoform 1 (human)
hGCLC/iso:1
"A glutamate--cysteine ligase catalytic subunit isoform 1 that is encoded in the genome of human." [PRO:DNx]

organism-modification


PR:000073811
glutamate--cysteine ligase catalytic subunit methylated 1 (human)
hGCLC/Me:1
"A glutamate--cysteine ligase catalytic subunit (human) that has been methylated on the residue at the position equivalent to Cys-273 of the amino acid sequence represented by UniProtKB:P48506. UniProtKB:P48506, Cys-273, MOD:00660." [IEDB_epitope:1032586, PRO:DNx]

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hGCLC forms found in complexes   

hGCLC Component
 Complexes
PR:P48506 hGCLC PR:000027406 glutamate-cysteine ligase complex (human)