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Protein Ontology report - serine/threonine-protein kinase PLK1 (human)
PR:P53350 -
http://purl.obolibrary.org/obo/PR_P53350
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:P53350
PRO name
serine/threonine-protein kinase PLK1 (human)
Synonyms
PRO-Short-label
:
EXACT:
hPLK1
Gene-based
:
RELATED:
PLK | PLK1
Other
:
EXACT:
PLK-1 (human) | Polo-like kinase 1 (human) | STPK13 (human)
Definition
"A serine/threonine-protein kinase PLK1 that is encoded in the genome of human." [
PMID:16129782
,
PMID:16580887
,
PMID:16760428
,
PMID:17376779
,
PMID:20624902
,
PMID:20823832
, PRO:KER]
PRO Category
organism-gene
Parent
PR:000012870
serine/threonine-protein kinase PLK1
PR:000029067
Homo sapiens protein
Gene Template
HGNC:9077
PLK1 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
1
Modification
0
Organism-Modification
8
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:P53350
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
comp.
In Complex?
organism-gene
PR:P53350
serine/threonine-protein kinase PLK1 (human)
hPLK1
Yes
Yes
organism-sequence
PR:P53350-1
serine/threonine-protein kinase PLK1 isoform 1 (human)
hPLK1/iso:1
organism-modification
PR:000035669
serine/threonine-protein kinase PLK1 unphosphorylated form (human)
hPLK1/PhosRes-
organism-modification
PR:000044818
serine/threonine-protein kinase PLK1 phosphorylated 1 (human)
hPLK1/Phos:1
Yes
organism-modification
PR:000045826
serine/threonine-protein kinase PLK1 phosphorylated 2 (human)
hPLK1/Phos:2
organism-modification
PR:000048813
serine/threonine-protein kinase PLK1 phosphorylated 3 (human)
hPLK1/Phos:3
organism-modification
PR:000068734
serine/threonine-protein kinase PLK1 methylated 1 (human)
hPLK1/Me:1
organism-modification
PR:000075930
serine/threonine-protein kinase PLK1 deaminated 1 (human)
hPLK1/Deam:1
organism-modification
PR:000076381
serine/threonine-protein kinase PLK1 methylated 2 (human)
hPLK1/Me:2
organism-modification
PR:000083595
serine/threonine-protein kinase PLK1 cysteinylated 1 (human)
hPLK1/Cyst:1
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hPLK1
forms found in complexes
hPLK1
Component
Complexes
PR:P53350
hPLK1
PR:000035581
phosphoBUB1:PLK1 complex (human)
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000044818
hPLK1/Phos:1
UniProtKB:P53350, Ser-99, MOD:00046|Thr-210, MOD:00047
acts_upstream_of_or_within
GO:0007091
metaphase/anaphase transition of mitotic cell cycle
PMID:23695676
enables
GO:0071889
14-3-3 protein binding
with
PR:P61981
hYWHAG
PMID:23695676
PR:P53350
hPLK1
acts_upstream_of_or_within
GO:0008608
attachment of spindle microtubules to kinetochore
PMID:17376779
NOT
GO:0031577
spindle checkpoint signaling
PMID:16760428
GO:0034092
negative regulation of maintenance of sister chromatid cohesion
PMID:16580887
NOT
GO:0034501
protein localization to kinetochore
PMID:16760428
NOT
GO:0034501
protein localization to kinetochore
PMID:16760428
NOT
GO:0034501
protein localization to kinetochore
PMID:16760428
GO:0051310
metaphase chromosome alignment
PMID:17376779
enables
GO:0004672
protein kinase activity
PMID:16760428
GO:0005515
protein binding
with
PR:O43683
BUB1
BioGRID:BG-338598
GO:0005515
protein binding
with
PR:O60566
BUB1B
BioGRID:BG-338598
GO:0005515
protein binding
with
PR:Q5FBB7
hSGO1
BioGRID:BG-338598
GO:0005515
protein binding
BioGRID:BG-338598
located_in
GO:0000776
kinetochore
PMID:20624902
GO:0000922
spindle pole
PMID:20823832
GO:0000940
outer kinetochore
PMID:16760428
GO:0005813
centrosome
PMID:16760428