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Protein Ontology report - potassium voltage-gated channel subfamily KQT member 4 (human)
PR:P56696 - http://purl.obolibrary.org/obo/PR_P56696
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P56696   
  PRO namepotassium voltage-gated channel subfamily KQT member 4 (human) 
  Synonyms
PRO-Short-label: EXACT:hKCNQ4
Gene-based: RELATED:KCNQ4
Other: EXACT:KQT-like 4 (human) | potassium channel subunit alpha KvLQT4 (human) | voltage-gated potassium channel subunit Kv7.4 (human)
  Definition"A voltage-gated potassium channel subunit KCNQ4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P56696] 
  PRO Categoryorganism-gene 
  ParentPR:000000731 voltage-gated potassium channel subunit KCNQ4
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:6298 KCNQ4 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 8                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P56696
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
organism-gene


PR:P56696
potassium voltage-gated channel subfamily KQT member 4 (human)
hKCNQ4
"A voltage-gated potassium channel subunit KCNQ4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P56696]

organism-sequence


PR:000000920
voltage-gated potassium channel subunit KCNQ4 sequence variant G285C (human)
hKCNQ4/var:G285C
"A potassium voltage-gated channel subfamily KQT member 4 (human) that has a Cys residue at the position equivalent to Gly-285 of the amino acid sequence represented by UniProtKB:P56696-1. This variation is at the first Gly in the conserved selectivity filter sequence GYGD within the pore region. Example: UniProtKB:P56696-1, Gly-285, CHEBI:29950." [PMID:10369879, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000921
voltage-gated potassium channel subunit KCNQ4 sequence variant L274H (human)
hKCNQ4/var:L274H
"A potassium voltage-gated channel subfamily KQT member 4 (human) that has a His residue at the position equivalent to Leu-274 of the amino acid sequence represented by UniProtKB:P56696-1. Example: UniProtKB:P56696-1, Leu-274, CHEBI:29979." [PMID:10925378, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000922
voltage-gated potassium channel subunit KCNQ4 sequence variant G285S (human)
hKCNQ4/var:G285S
"A potassium voltage-gated channel subfamily KQT member 4 (human) that has a Ser residue at the position equivalent to Gly-285 of the amino acid sequence represented by UniProtKB:P56696-1. This variation is at the first Gly in the conserved selectivity filter sequence GYGD within the pore region. Example: UniProtKB:P56696-1, Gly-285, CHEBI:29999." [PMID:10025409, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000923
voltage-gated potassium channel subunit KCNQ4 sequence variant L281S (human)
hKCNQ4/var:L281S
"A potassium voltage-gated channel subfamily KQT member 4 (human) that has a Ser residue at the position equivalent to Leu-281 of the amino acid sequence represented by UniProtKB:P56696-1. Example: UniProtKB:P56696-1, Leu-281, CHEBI:29999." [PMID:10571947, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000924
voltage-gated potassium channel subunit KCNQ4 sequence variant W276S (human)
hKCNQ4/var:W276S
"A potassium voltage-gated channel subfamily KQT member 4 (human) that has a Ser residue at the position equivalent to Trp-276 of the amino acid sequence represented by UniProtKB:P56696-1. Example: UniProtKB:P56696-1, Trp-276, CHEBI:29999." [PMID:10369879, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000925
voltage-gated potassium channel subunit KCNQ4 sequence variant G321S (human)
hKCNQ4/var:G321S
"A potassium voltage-gated channel subfamily KQT member 4 (human) that has a Ser residue at the position equivalent to Gly-321 of the amino acid sequence represented by UniProtKB:P56696-1. Example: UniProtKB:P56696-1, Gly-321, CHEBI:29999." [PMID:10369879, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:P56696-1
potassium voltage-gated channel subfamily KQT member 4 isoform 1 (human)
hKCNQ4/iso:1
"A voltage-gated potassium channel subunit KCNQ4 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-sequence


PR:P56696-2
potassium voltage-gated channel subfamily KQT member 4 isoform 2 (human)
hKCNQ4/iso:2
"A voltage-gated potassium channel subunit KCNQ4 isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P56696]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000920 hKCNQ4/var:G285C
Example: UniProtKB:P56696-1, Gly-285, CHEBI:29950		 associated_with_disease_progressionDO:0050564 autosomal dominant nonsyndromic deafness PMID:10369879
enablesaltered GO:0005249 voltage-gated potassium channel activity relative to PR:000000918 KCNQ4/iso:1 PMID:10369879
PR:000000921 hKCNQ4/var:L274H
Example: UniProtKB:P56696-1, Leu-274, CHEBI:29979		 associated_with_disease_progressionDO:0050564 autosomal dominant nonsyndromic deafness PMID:10925378
PR:000000922 hKCNQ4/var:G285S
Example: UniProtKB:P56696-1, Gly-285, CHEBI:29999		 associated_with_disease_progressionDO:0050564 autosomal dominant nonsyndromic deafness PMID:10025409
enablesaltered GO:0005249 voltage-gated potassium channel activity relative to PR:000000918 KCNQ4/iso:1 PMID:10025409
PR:000000923 hKCNQ4/var:L281S
Example: UniProtKB:P56696-1, Leu-281, CHEBI:29999		 associated_with_disease_progressionDO:0050564 autosomal dominant nonsyndromic deafness PMID:10571947
PR:000000924 hKCNQ4/var:W276S
Example: UniProtKB:P56696-1, Trp-276, CHEBI:29999		 associated_with_disease_progressionDO:0050564 autosomal dominant nonsyndromic deafness PMID:10369879
PR:000000925 hKCNQ4/var:G321S
Example: UniProtKB:P56696-1, Gly-321, CHEBI:29999		 associated_with_disease_progressionDO:0050564 autosomal dominant nonsyndromic deafness PMID:10369879