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Protein Ontology report - transforming growth factor beta-2 (human)
PR:P61812 -
http://purl.obolibrary.org/obo/PR_P61812
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:P61812
PRO name
transforming growth factor beta-2 (human)
Synonyms
PRO-Short-label
:
EXACT:
hTGFB2
Gene-based
:
RELATED:
TGFB2
Other
:
EXACT:
cetermin (human) | G-TSF (human) | glioblastoma-derived T-cell suppressor factor (human)
Definition
"A TGF-beta 2 that is encoded in the genome of human." [PRO:CNA,
UniProtKB:P61812
]
PRO Category
organism-gene
Parent
PR:000000183
TGF-beta 2
PR:000029067
Homo sapiens protein
Gene Template
HGNC:11768
TGFB2 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
2
Modification
0
Organism-Modification
6
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:P61812
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
organism-gene
PR:P61812
transforming growth factor beta-2 (human)
hTGFB2
"A TGF-beta 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P61812]
organism-sequence
PR:P61812-1
transforming growth factor beta-2 isoform A (human)
hTGFB2/iso:A
"A TGF-beta 2 isoform A that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification
PR:000036530
TGF-beta 2 isoform A cleaved 1 (human)
hTGFB2/iso:A/Clv:1
"A TGF-beta 2 isoform A cleaved 1 in human. UniProtKB:P61812-1, 303-414." [PMID:15944186, PMID:16227582, PMID:2119582, PMID:3162913, PMID:3476488, PRO:CNA]
Yes
organism-modification
PR:000036532
TGF-beta 2 isoform A cleaved 2 (human)
hTGFB2/iso:A/Clv:2
"A TGF-beta 2 isoform A cleaved 2 in human. UniProtKB:P61812-1, 20-302." [PMID:3162913, PRO:CNA]
Yes
organism-modification
PR:000036533
TGF-beta 2 isoform A cleaved 3 (human)
hTGFB2/iso:A/Clv:3
"A TGF-beta 2 isoform A cleaved 3 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-1, 20-302, 303-414." [PMID:3162913, PMID:3476488, PRO:CNA]
Yes
organism-sequence
PR:P61812-2
transforming growth factor beta-2 isoform B (human)
hTGFB2/iso:B
"A TGF-beta 2 isoform B that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification
PR:000036534
TGF-beta 2 isoform B cleaved 1 (human)
hTGFB2/iso:B/Clv:1
"A TGF-beta 2 isoform B cleaved 1 in human. UniProtKB:P61812-2, 331-442." [PMID:1777240, PRO:CNA]
Yes
organism-modification
PR:000036535
TGF-beta 2 isoform B cleaved 2 (human)
hTGFB2/iso:B/Clv:2
"A TGF-beta 2 isoform B cleaved 2 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-2, 20-330, 331-442." [PMID:1777240, PRO:CNA]
Yes
organism-modification
PR:000069517
transforming growth factor beta-2 methylated 1 (human)
hTGFB2/Me:1
"A transforming growth factor beta-2 (human) that has been methylated on the residue at the position equivalent to Cys-4 of the amino acid sequence represented by UniProtKB:P61812. UniProtKB:P61812, Cys-4, MOD:00660." [IEDB_epitope:1019772, PRO:DNx]
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036530
hTGFB2/iso:A/Clv:1
UniProtKB:P61812-1, 303-414
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:3162913
GO:0008285
negative regulation of cell population proliferation
PMID:15944186
enables
GO:0001540
amyloid-beta binding
PMID:16227582
GO:0005160
transforming growth factor beta receptor binding
PMID:16227582
GO:0042803
protein homodimerization activity
PMID:2119582
;
PMID:3476488
located_in
GO:0005615
extracellular space
PMID:3162913
PR:000036532
hTGFB2/iso:A/Clv:2
UniProtKB:P61812-1, 20-302
located_in
GO:0032991
protein-containing complex
PMID:3162913
PR:000036533
hTGFB2/iso:A/Clv:3
UniProtKB:P61812-1, 20-302, 303-414
enables
GO:0042803
protein homodimerization activity
PMID:3476488
located_in
GO:0005615
extracellular space
PMID:3162913
PR:000036534
hTGFB2/iso:B/Clv:1
UniProtKB:P61812-2, 331-442
located_in
GO:0005615
extracellular space
PMID:1777240
PR:000036535
hTGFB2/iso:B/Clv:2
UniProtKB:P61812-2, 20-330, 331-442
located_in
GO:0005615
extracellular space
PMID:1777240
PR:P61812-1
hTGFB2/iso:A
enables
GO:0046982
protein heterodimerization activity
PMID:2119582
PR:P61812-2
hTGFB2/iso:B
enables
GO:0046982
protein heterodimerization activity
PMID:17845732
located_in
GO:0045177
apical part of cell
PMID:17845732
