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Protein Ontology report - centromere-associated protein E (human)
PR:Q02224 - http://purl.obolibrary.org/obo/PR_Q02224
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q02224   
  PRO namecentromere-associated protein E (human) 
  Synonyms
PRO-Short-label: EXACT:hCENPE
Gene-based: RELATED:CENPE
Other: EXACT:CENP-E (human) | centromere protein E (human) | kinesin-7 (human) | kinesin-related protein CENPE (human)
  Definition"A centromere-associated protein E that is encoded in the genome of human." [PMID:12719470, PMID:15592459, PMID:17785528, PRO:KER] 
  PRO Categoryorganism-gene 
  ParentPR:000005326 centromere-associated protein E
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:1856 CENPE (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q02224
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
organism-gene



PR:Q02224

centromere-associated protein E (human)

hCENPE


"A centromere-associated protein E that is encoded in the genome of human." [PMID:12719470, PMID:15592459, PMID:17785528, PRO:KER]

Yes

organism-sequence



PR:Q02224-1

centromere-associated protein E isoform h1 (human)

hCENPE/iso:h1


"A centromere-associated protein E (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02224-1." [PRO:DNx, UniProtKB:Q02224]


organism-sequence



PR:Q02224-3

centromere-associated protein E isoform h3 (human)

hCENPE/iso:h3


"A centromere-associated protein E (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02224-3." [PRO:DNx, UniProtKB:Q02224]


organism-modification



PR:000065456

centromere-associated protein E deaminated 1 (human)

hCENPE/Deam:1


"A centromere-associated protein E (human) that has been deaminated on the residue at the position equivalent to Gln-1907 of the amino acid sequence represented by UniProtKB:Q02224-1. Example: UniProtKB:Q02224-1, Gln-1907, MOD:00685." [IEDB_epitope:1342778, PRO:DNx]


organism-modification



PR:000072868

centromere-associated protein E phosphorylated 1 (human)

hCENPE/Phos:1


"A centromere-associated protein E (human) that has been phosphorylated on the residue at the position equivalent to Thr-2540 of the amino acid sequence represented by UniProtKB:Q02224-1. Example: UniProtKB:Q02224-1, Thr-2540, MOD:00047." [IEDB_epitope:2149369, PRO:DNx]


organism-modification



PR:000077661

centromere-associated protein E deaminated 2 (human)

hCENPE/Deam:2


"A centromere-associated protein E (human) that has been deaminated on the residue at the position equivalent to Gln-977 of the amino acid sequence represented by UniProtKB:Q02224-1. Example: UniProtKB:Q02224-1, Gln-977, MOD:00685." [IEDB_epitope:1974671, PRO:DNx]


organism-modification



PR:000080776

centromere-associated protein E cysteinylated 1 (human)

hCENPE/Cyst:1


"A centromere-associated protein E (human) that has been cysteinylated on the residue at the position equivalent to Cys-2162 of the amino acid sequence represented by UniProtKB:Q02224-1. Example: UniProtKB:Q02224-1, Cys-2162, MOD:00765." [IEDB_epitope:1582779, PRO:DNx]


organism-modification



PR:000082966

centromere-associated protein E methylated 1 (human)

hCENPE/Me:1


"A centromere-associated protein E (human) that has been methylated on the residue at the position equivalent to Cys-2297 of the amino acid sequence represented by UniProtKB:Q02224-1. Example: UniProtKB:Q02224-1, Cys-2297, MOD:00660." [IEDB_epitope:1023726, PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q02224 hCENPE acts_upstream_of_or_withinGO:0033674 positive regulation of kinase activity PMID:22801780
GO:0034501 protein localization to kinetochore PMID:17785528
GO:0051310 metaphase chromosome alignment PMID:15592459
enablesGO:0005515 protein binding with PR:O60566 BUB1B BioGRID:BG-545452; IntAct:EBI-1646673
GO:0005515 protein binding with PR:P49454 AH antigen (human) BioGRID:BG-545452; IntAct:EBI-1646673
GO:0005515 protein binding with PR:Q9BZD4 CDCA1 BioGRID:BG-545452; IntAct:EBI-1646673
located_inGO:0000776 kinetochore PMID:12719470