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Documentation
Protein Ontology report - noggin (human)
PR:Q13253 -
http://purl.obolibrary.org/obo/PR_Q13253
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:Q13253
PRO name
noggin (human)
Synonyms
PRO-Short-label
:
EXACT:
hNOG
Gene-based
:
RELATED:
NOG
Definition
"A noggin that is encoded in the genome of human." [PRO:CNA,
UniProtKB:Q13253
]
PRO Category
organism-gene
Parent
PR:000000021
noggin
PR:000029067
Homo sapiens protein
Gene Template
HGNC:7866
NOG (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
11
Modification
0
Organism-Modification
2
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:Q13253
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
organism-gene
PR:Q13253
noggin (human)
hNOG
"A noggin that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13253]
organism-sequence
PR:000000107
noggin sequence variant P35S (human)
hNOG/var:P35S
"A noggin (human) that has a Ser residue at the position equivalent to Pro-35 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Pro-35, CHEBI:29999." [PMID:11857750, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000108
noggin sequence variant P223L (human)
hNOG/var:P223L
"A noggin (human) that has a Leu residue at the position equivalent to Pro-223 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Pro-223, CHEBI:30006." [PMID:10080184, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000109
noggin sequence variant P35R (human)
hNOG/var:P35R
"A noggin (human) that has an Arg residue at the position equivalent to Pro-35 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Pro-35, CHEBI:29952." [PMID:11545688, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000110
noggin sequence variant C184Y (human)
hNOG/var:C184Y
"A noggin (human) that has a Tyr residue at the position equivalent to Cys-184 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Cys-184, CHEBI:46858." [PMID:11846737, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000111
noggin sequence variant G189C (human)
hNOG/var:G189C
"A noggin (human) that has a Cys residue at the position equivalent to Gly-189 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Gly-189, CHEBI:29950." [PMID:99178269, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000112
noggin sequence variant R204L (human)
hNOG/var:R204L
"A noggin (human) that has a Leu residue at the position equivalent to Arg-204 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Arg-204, CHEBI:30006." [PMID:11545688, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000113
noggin sequence variant W217G (human)
hNOG/var:W217G
"A noggin (human) that has a Gly residue at the position equivalent to Trp-217 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Trp-217, CHEBI:29947." [PMID:10080184, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000114
noggin sequence variant I220N (human)
hNOG/var:I220N
"A noggin (human) that has an Asn residue at the position equivalent to Ile-220 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Ile-220, CHEBI:50347." [PMID:10080184, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000115
noggin sequence variant Y222C (human)
hNOG/var:Y222C
"A noggin (human) that has a Cys residue at the position equivalent to Tyr-222 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Tyr-222, CHEBI:29950." [PMID:10080184, PMID:11545688, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000116
noggin sequence variant Y222D (human)
hNOG/var:Y222D
"A noggin (human) that has an Asp residue at the position equivalent to Tyr-222 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Tyr-222, CHEBI:29958." [PMID:10080184, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:Q13253-1
noggin isoform 1 (human)
hNOG/iso:1
"A noggin isoform 1 that is encoded in the genome of human." [PRO:CNA]
organism-modification
PR:000036421
noggin isoform 1, signal peptide removed form (human)
hNOG/iso:1/SigPep-
"A noggin isoform 1, signal peptide removed form in human. UniProtKB:Q13253-1, 28-232." [PMID:11562478, PMID:12478285, PRO:CNA]
Yes
organism-modification
PR:000057007
noggin O-glycosylated 1 (human)
hNOG/OGlyco:1
"A noggin (human) that has been O-glycosylated at the residue equivalent to Thr-81 of the amino acid sequence represented by UniProtKB:Q13253-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q13253-1, Thr-81, MOD:00005~GNO:G43417UB." [GlyGen:Q13253-1, PMID:30459171, PRO:DNx]
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000107
hNOG/var:P35S
UniProtKB:Q13253, Pro-35, CHEBI:29999
associated_with_disease_progression
DO:0050788
proximal symphalangism
PMID:11857750
PR:000000108
hNOG/var:P223L
UniProtKB:Q13253, Pro-223, CHEBI:30006
associated_with_disease_progression
DO:0050788
proximal symphalangism
PMID:10080184
PR:000000109
hNOG/var:P35R
UniProtKB:Q13253, Pro-35, CHEBI:29952
associated_with_disease_progression
DO:0050788
proximal symphalangism
PMID:11545688
DO:0050789
tarsal-carpal coalition syndrome
PMID:11545688
PR:000000110
hNOG/var:C184Y
UniProtKB:Q13253, Cys-184, CHEBI:46858
associated_with_disease_progression
DO:0050788
proximal symphalangism
PMID:11846737
PR:000000111
hNOG/var:G189C
UniProtKB:Q13253, Gly-189, CHEBI:29950
associated_with_disease_progression
DO:0050788
proximal symphalangism
PMID:99178269
PR:000000112
hNOG/var:R204L
UniProtKB:Q13253, Arg-204, CHEBI:30006
associated_with_disease_progression
DO:0050789
tarsal-carpal coalition syndrome
PMID:11545688
PR:000000113
hNOG/var:W217G
UniProtKB:Q13253, Trp-217, CHEBI:29947
associated_with_disease_progression
DO:0050788
proximal symphalangism
PMID:10080184
PR:000000114
hNOG/var:I220N
UniProtKB:Q13253, Ile-220, CHEBI:50347
associated_with_disease_progression
DO:0050788
proximal symphalangism
PMID:10080184
PR:000000115
hNOG/var:Y222C
UniProtKB:Q13253, Tyr-222, CHEBI:29950
associated_with_disease_progression
DO:0050788
proximal symphalangism
PMID:11545688
DO:0050789
tarsal-carpal coalition syndrome
PMID:10080184
PR:000000116
hNOG/var:Y222D
UniProtKB:Q13253, Tyr-222, CHEBI:29958
associated_with_disease_progression
DO:0050788
proximal symphalangism
PMID:10080184
PR:000036421
hNOG/iso:1/SigPep-
UniProtKB:Q13253-1, 28-232
acts_upstream_of_or_within
GO:0030514
negative regulation of BMP signaling pathway
PMID:12478285
enables
GO:0005515
protein binding
with
PR:000036517
hBMP7/iso:1/mature/NGlyco:1
PMID:12478285
located_in
GO:0005615
extracellular space
PMID:11562478