back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - noggin (human)
PR:Q13253 - http://purl.obolibrary.org/obo/PR_Q13253
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q13253   
  PRO namenoggin (human) 
  Synonyms
PRO-Short-label: EXACT:hNOG
Gene-based: RELATED:NOG
  Definition"A noggin that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13253
  PRO Categoryorganism-gene 
  ParentPR:000000021 noggin
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:7866 NOG (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 11                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
UniProtKB:Q13253
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
organism-gene



PR:Q13253

noggin (human)

hNOG


"A noggin that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13253]


organism-sequence



PR:000000107

noggin sequence variant P35S (human)

hNOG/var:P35S


"A noggin (human) that has a Ser residue at the position equivalent to Pro-35 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Pro-35, CHEBI:29999." [PMID:11857750, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000108

noggin sequence variant P223L (human)

hNOG/var:P223L


"A noggin (human) that has a Leu residue at the position equivalent to Pro-223 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Pro-223, CHEBI:30006." [PMID:10080184, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000109

noggin sequence variant P35R (human)

hNOG/var:P35R


"A noggin (human) that has an Arg residue at the position equivalent to Pro-35 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Pro-35, CHEBI:29952." [PMID:11545688, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000110

noggin sequence variant C184Y (human)

hNOG/var:C184Y


"A noggin (human) that has a Tyr residue at the position equivalent to Cys-184 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Cys-184, CHEBI:46858." [PMID:11846737, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000111

noggin sequence variant G189C (human)

hNOG/var:G189C


"A noggin (human) that has a Cys residue at the position equivalent to Gly-189 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Gly-189, CHEBI:29950." [PMID:99178269, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000112

noggin sequence variant R204L (human)

hNOG/var:R204L


"A noggin (human) that has a Leu residue at the position equivalent to Arg-204 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Arg-204, CHEBI:30006." [PMID:11545688, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000113

noggin sequence variant W217G (human)

hNOG/var:W217G


"A noggin (human) that has a Gly residue at the position equivalent to Trp-217 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Trp-217, CHEBI:29947." [PMID:10080184, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000114

noggin sequence variant I220N (human)

hNOG/var:I220N


"A noggin (human) that has an Asn residue at the position equivalent to Ile-220 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Ile-220, CHEBI:50347." [PMID:10080184, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000115

noggin sequence variant Y222C (human)

hNOG/var:Y222C


"A noggin (human) that has a Cys residue at the position equivalent to Tyr-222 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Tyr-222, CHEBI:29950." [PMID:10080184, PMID:11545688, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000116

noggin sequence variant Y222D (human)

hNOG/var:Y222D


"A noggin (human) that has an Asp residue at the position equivalent to Tyr-222 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Tyr-222, CHEBI:29958." [PMID:10080184, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:Q13253-1

noggin isoform 1 (human)

hNOG/iso:1


"A noggin isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036421

noggin isoform 1, signal peptide removed form (human)

hNOG/iso:1/SigPep-


"A noggin isoform 1, signal peptide removed form in human. UniProtKB:Q13253-1, 28-232." [PMID:11562478, PMID:12478285, PRO:CNA]

Yes

organism-modification



PR:000057007

noggin O-glycosylated 1 (human)

hNOG/OGlyco:1


"A noggin (human) that has been O-glycosylated at the residue equivalent to Thr-81 of the amino acid sequence represented by UniProtKB:Q13253-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q13253-1, Thr-81, MOD:00005~GNO:G43417UB." [GlyGen:Q13253-1, PMID:30459171, PRO:DNx]


Back to top
Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0030514 negative regulation of BMP signaling pathwayPR:000036421 hNOG/iso:1/SigPep- PMID:12478285

Disease Associated GO Term

Protein Forms & Complexes

Evidence
DO:0050788 proximal symphalangismPR:000000107 hNOG/var:P35S PMID:11857750
PR:000000108 hNOG/var:P223L PMID:10080184
PR:000000109 hNOG/var:P35R PMID:11545688
PR:000000110 hNOG/var:C184Y PMID:11846737
PR:000000111 hNOG/var:G189C PMID:99178269
PR:000000113 hNOG/var:W217G PMID:10080184
PR:000000114 hNOG/var:I220N PMID:10080184
PR:000000115 hNOG/var:Y222C PMID:11545688
PR:000000116 hNOG/var:Y222D PMID:10080184
DO:0050789 tarsal-carpal coalition syndromePR:000000109 hNOG/var:P35R PMID:11545688
PR:000000112 hNOG/var:R204L PMID:11545688
PR:000000115 hNOG/var:Y222C PMID:10080184

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005515 protein bindingPR:000036421 hNOG/iso:1/SigPep- PMID:12478285

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005615 extracellular spacePR:000036421 hNOG/iso:1/SigPep- PMID:11562478