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Protein Ontology report - noggin (human)
PR:Q13253 - http://purl.obolibrary.org/obo/PR_Q13253
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q13253   
  PRO namenoggin (human) 
  Synonyms
PRO-Short-label: EXACT:hNOG
Gene-based: RELATED:NOG
  Definition"A noggin that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13253] 
  PRO Categoryorganism-gene 
  ParentPR:000000021 noggin
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:7866 NOG (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 11                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q13253
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
organism-gene


PR:Q13253 noggin (human)
hNOG

organism-sequence


PR:000000107 noggin sequence variant P35S (human)
hNOG/var:P35S
Yes
organism-sequence


PR:000000108 noggin sequence variant P223L (human)
hNOG/var:P223L
Yes
organism-sequence


PR:000000109 noggin sequence variant P35R (human)
hNOG/var:P35R
Yes
organism-sequence


PR:000000110 noggin sequence variant C184Y (human)
hNOG/var:C184Y
Yes
organism-sequence


PR:000000111 noggin sequence variant G189C (human)
hNOG/var:G189C
Yes
organism-sequence


PR:000000112 noggin sequence variant R204L (human)
hNOG/var:R204L
Yes
organism-sequence


PR:000000113 noggin sequence variant W217G (human)
hNOG/var:W217G
Yes
organism-sequence


PR:000000114 noggin sequence variant I220N (human)
hNOG/var:I220N
Yes
organism-sequence


PR:000000115 noggin sequence variant Y222C (human)
hNOG/var:Y222C
Yes
organism-sequence


PR:000000116 noggin sequence variant Y222D (human)
hNOG/var:Y222D
Yes
organism-sequence


PR:Q13253-1 noggin isoform 1 (human)
hNOG/iso:1

organism-modification


PR:000036421 noggin isoform 1, signal peptide removed form (human)
hNOG/iso:1/SigPep-
Yes
organism-modification


PR:000057007 noggin O-glycosylated 1 (human)
hNOG/OGlyco:1

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0030514 negative regulation of BMP signaling pathwayPR:000036421 hNOG/iso:1/SigPep- PMID:12478285

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:0050788 proximal symphalangismPR:000000107 hNOG/var:P35S PMID:11857750
PR:000000108 hNOG/var:P223L PMID:10080184
PR:000000109 hNOG/var:P35R PMID:11545688
PR:000000110 hNOG/var:C184Y PMID:11846737
PR:000000111 hNOG/var:G189C PMID:99178269
PR:000000113 hNOG/var:W217G PMID:10080184
PR:000000114 hNOG/var:I220N PMID:10080184
PR:000000115 hNOG/var:Y222C PMID:11545688
PR:000000116 hNOG/var:Y222D PMID:10080184
DO:0050789 tarsal-carpal coalition syndromePR:000000109 hNOG/var:P35R PMID:11545688
PR:000000112 hNOG/var:R204L PMID:11545688
PR:000000115 hNOG/var:Y222C PMID:10080184

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005515 protein bindingPR:000036421 hNOG/iso:1/SigPep- PMID:12478285

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615 extracellular spacePR:000036421 hNOG/iso:1/SigPep- PMID:11562478