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Protein Ontology report - receptor-interacting serine/threonine-protein kinase 1 (human)
PR:Q13546 - http://purl.obolibrary.org/obo/PR_Q13546
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q13546   
  PRO namereceptor-interacting serine/threonine-protein kinase 1 (human) 
  Synonyms
PRO-Short-label: EXACT:hRIPK1
Gene-based: RELATED:RIP | RIP1 | RIPK1
Other: EXACT:cell death protein RIP (human) | receptor-interacting protein 1 (human) | RIP-1 (human)
  Definition"A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human." [PRO:DNx] 
  PRO Categoryorganism-gene 
  ParentPR:000014022 receptor-interacting serine/threonine-protein kinase 1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:10019 RIPK1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 6                                        
         Modification0                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q13546
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
organism-gene



PR:Q13546

receptor-interacting serine/threonine-protein kinase 1 (human)

hRIPK1


"A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human." [PRO:DNx]


Yes
organism-sequence



PR:000060700

receptor-interacting serine/threonine-protein kinase 1 sequence variant D324N (human)

hRIPK1/var:D324N


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has an Asn residue at the position equivalent to Asp-324 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Asp-324, CHEBI:50347." [PRO:DNx, Reactome:R-HSA-9693930]


organism-sequence



PR:000061515

receptor-interacting serine/threonine-protein kinase 1 sequence variant D324V (human)

hRIPK1/var:D324V


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has a Val residue at the position equivalent to Asp-324 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Asp-324, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9693927]


organism-sequence



PR:000061610

receptor-interacting serine/threonine-protein kinase 1 sequence variant D324Y (human)

hRIPK1/var:D324Y


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has a Tyr residue at the position equivalent to Asp-324 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Asp-324, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-9693931]


organism-sequence



PR:000062596

receptor-interacting serine/threonine-protein kinase 1 sequence variant D324H (human)

hRIPK1/var:D324H


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has a His residue at the position equivalent to Asp-324 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Asp-324, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-9693922]


organism-sequence



PR:Q13546-1

receptor-interacting serine/threonine-protein kinase 1 isoform 1 (human)

hRIPK1/iso:1


"A receptor-interacting serine/threonine-protein kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CC]


organism-modification



PR:000036649

receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated 1 (human)

hRIPK1/iso:1/Ubiq:1


"A receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated 1 in human." [PMID:19734906, PRO:CNA]

Yes

organism-sequence



PR:Q13546-2

receptor-interacting serine/threonine-protein kinase 1 isoform h2 (human)

hRIPK1/iso:h2


"A receptor-interacting serine/threonine-protein kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13546-2." [PRO:DNx, UniProtKB:Q13546]


organism-modification



PR:000036051

receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 (human)

hRIPK1/K63polyUbiq:1


"A receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 in human. UniProtKB:Q13546, Lys-377, PR:000044772." [Reactome:R-HSA-937021]

Yes

Yes
organism-modification



PR:000049045

receptor-interacting serine/threonine-protein kinase 1 phosphoserine form (human)

hRIPK1/PhosSer+


"A receptor-interacting serine/threonine-protein kinase 1 (human) that includes at least one phosphorylated serine. UniProtKB:Q13546, MOD:00046." [PRO:DNx, Reactome:R-HSA-5218872]


organism-modification



PR:000062016

receptor-interacting serine/threonine-protein kinase 1 phosphorylated 1 (human)

hRIPK1/Phos:1


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-357 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Ser-357, MOD:00046." [PRO:DNx, Reactome:R-HSA-9819116]


organism-modification



PR:000063041

receptor-interacting serine/threonine-protein kinase 1 phosphorylated 2 (human)

hRIPK1/Phos:2


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-320 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Ser-320, MOD:00046." [PRO:DNx, Reactome:R-HSA-9815498]


organism-modification



PR:000064671

receptor-interacting serine/threonine-protein kinase 1 ubiquitinated 1 (human)

hRIPK1/Ubiq:1


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has been ubiquitinated on the residues at the positions equivalent to Lys-571, Lys-604, and Lys-627 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Lys-571/Lys-604/Lys-627, MOD:01148." [PRO:DNx, Reactome:R-HSA-9796639]


organism-modification



PR:000064778

receptor-interacting serine/threonine-protein kinase 1 ubiquitinated form (human)

hRIPK1/UbiqLys+


"A receptor-interacting serine/threonine-protein kinase 1 (human) that includes at least 1 ubiquitinated lysine. UniProtKB:Q13546, MOD:01148." [PRO:DNx, Reactome:R-HSA-6783197, Reactome:R-HSA-6783308]


organism-modification



PR:000064853

receptor-interacting serine/threonine-protein kinase 1 ubiquitinated 2 (human)

hRIPK1/Ubiq:2


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has been ubiquitinated on the residues at the positions equivalent to Lys-377, Lys-604, and Lys-634 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Lys-377/Lys-604/Lys-634, MOD:01148." [PRO:DNx, Reactome:R-HSA-9818391]


organism-modification



PR:000069926

receptor-interacting serine/threonine-protein kinase 1 methylated 1 (human)

hRIPK1/Me:1


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has been methylated on the residue at the position equivalent to Cys-656 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Cys-656, MOD:00660." [IEDB_epitope:1018920, PRO:DNx]


organism-modification



PR:000075119

receptor-interacting serine/threonine-protein kinase 1 cysteinylated 1 (human)

hRIPK1/Cyst:1


"A receptor-interacting serine/threonine-protein kinase 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-656 of the amino acid sequence represented by UniProtKB:Q13546-1. Example: UniProtKB:Q13546-1, Cys-656, MOD:00765." [IEDB_epitope:927758, PRO:DNx]


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hRIPK1 forms found in complexes   

hRIPK1 Component
Complexes
PR:000036051 hRIPK1/K63polyUbiq:1 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:Q13546 hRIPK1 PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
PR:000028434 TRAF2:TRADD:RIP1 complex (human)
PR:000028435 TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human)
PR:000028437 TRAF2:TRADD:RIP1:FADD (human)
PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037334 rip1:ticam1:activated TLR3 complex (human)
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036051 hRIPK1/K63polyUbiq:1
UniProtKB:Q13546, Lys-377, PR:000044772
located_inGO:0005737 cytoplasm Reactome:REACT_26236
PR:000036649 hRIPK1/iso:1/Ubiq:1 enablesGO:0005515 protein binding with PR:Q8C669 mPELI1 PMID:19734906