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RACE-PRO
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Documentation
Protein Ontology report - cullin-1 (human)
PR:Q13616 -
http://purl.obolibrary.org/obo/PR_Q13616
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:Q13616
PRO name
cullin-1 (human)
Synonyms
PRO-Short-label
:
EXACT:
hCUL1
Gene-based
:
RELATED:
CUL1
Other
:
EXACT:
CUL-1 (human)
Definition
"A fungal/metazoan cullin-1 that is encoded in the genome of human." [PRO:DNx]
PRO Category
organism-gene
Parent
PR:000000092
fungal/metazoan cullin-1
PR:000029067
Homo sapiens protein
Gene Template
HGNC:2551
CUL1 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
1
Modification
0
Organism-Modification
4
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:Q13616
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
organism-gene
PR:Q13616
cullin-1 (human)
hCUL1
"A fungal/metazoan cullin-1 that is encoded in the genome of human." [PRO:DNx]
Yes
organism-sequence
PR:Q13616-1
cullin-1 isoform 1 (human)
hCUL1/iso:1
"A fungal/metazoan cullin-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification
PR:000036454
cullin-1 isoform 1 neddylated 1 (human)
hCUL1/iso:1/Nedd:1
"A fungal/metazoan cullin-1 isoform 1 neddylated 1 in human. UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156, PMID:10921923, PMID:17098746, PMID:8681378, PRO:CNA]
Yes
organism-modification
PR:000064861
cullin-1 neddylated 1 (human)
hCUL1/Nedd:1
"A cullin-1 (human) that has been neddylated on the residue at the position equivalent to Lys-720 of the amino acid sequence represented by UniProtKB:Q13616. UniProtKB:Q13616, Lys-720, MOD:01150." [PRO:DNx, Reactome:R-HSA-8952519]
organism-modification
PR:000071994
cullin-1 methylated 1 (human)
hCUL1/Me:1
"A cullin-1 (human) that has been methylated on the residue at the position equivalent to Cys-355 of the amino acid sequence represented by UniProtKB:Q13616. UniProtKB:Q13616, Cys-355, MOD:00660." [IEDB_epitope:1020279, PRO:DNx]
organism-modification
PR:000075174
cullin-1 cysteinylated 1 (human)
hCUL1/Cyst:1
"A cullin-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-551 of the amino acid sequence represented by UniProtKB:Q13616. UniProtKB:Q13616, Cys-551, MOD:00765." [IEDB_epitope:1583373, IEDB_epitope:1593153, PRO:DNx]
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hCUL1
forms found in complexes
hCUL1
Component
Complexes
PR:Q13616
hCUL1
PR:000026771
SCF beta-TrCP complex (human)
PR:000026772
SCF(Skp2) complex (human)
PR:000037513
FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex (human)
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Functional Annotation (GO-centric view)
Switch to
PRO Centric View
Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0008285
negative regulation of cell population proliferation
PR:000036454
hCUL1/iso:1/Nedd:1
PMID:8681378
GO:0031146
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
PR:000036454
hCUL1/iso:1/Nedd:1
PMID:10713156
;
PMID:10921923
GO:0051726
regulation of cell cycle
PR:000036454
hCUL1/iso:1/Nedd:1
PMID:8681378
GO:0097193
intrinsic apoptotic signaling pathway
PR:000036454
hCUL1/iso:1/Nedd:1
PMID:8681378
Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005515
protein binding
PR:Q13616-1
hCUL1/iso:1
PMID:12504026
;
PMID:15537541
PR:Q13616-1
hCUL1/iso:1
PMID:12504026
;
PMID:15537541
PR:Q13616-1
hCUL1/iso:1
PMID:12504026
;
PMID:15537541
PR:Q13616-1
hCUL1/iso:1
PMID:12504026
;
PMID:15537541
PR:Q13616-1
hCUL1/iso:1
PMID:12504026
;
PMID:15537541
PR:Q13616-1
hCUL1/iso:1
PMID:12504026
;
PMID:15537541
PR:Q13616-1
hCUL1/iso:1
PMID:12504026
;
PMID:15537541
PR:Q13616-1
hCUL1/iso:1
PMID:12504026
;
PMID:15537541
Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0019005
SCF ubiquitin ligase complex
PR:000036454
hCUL1/iso:1/Nedd:1
PMID:10713156
;
PMID:10921923
;
PMID:17098746
NOT
GO:0019005
SCF ubiquitin ligase complex
PR:Q13616-1
hCUL1/iso:1
PMID:10713156
;
PMID:10921923
;
PMID:12504026