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Protein Ontology report - cullin-1 (human)
PR:Q13616 - http://purl.obolibrary.org/obo/PR_Q13616
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q13616   
  PRO namecullin-1 (human) 
  Synonyms
PRO-Short-label: EXACT:hCUL1
Gene-based: RELATED:CUL1
Other: EXACT:CUL-1 (human)
  Definition"A fungal/metazoan cullin-1 that is encoded in the genome of human." [PRO:DNx] 
  PRO Categoryorganism-gene 
  ParentPR:000000092 fungal/metazoan cullin-1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:2551 CUL1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q13616
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
organism-gene


PR:Q13616 cullin-1 (human)
hCUL1

Yes
organism-sequence


PR:Q13616-1 cullin-1 isoform 1 (human)
hCUL1/iso:1
Yes
organism-modification


PR:000036454 cullin-1 isoform 1 neddylated 1 (human)
hCUL1/iso:1/Nedd:1
Yes
organism-modification


PR:000064861 cullin-1 neddylated 1 (human)
hCUL1/Nedd:1

organism-modification


PR:000071994 cullin-1 methylated 1 (human)
hCUL1/Me:1

organism-modification


PR:000075174 cullin-1 cysteinylated 1 (human)
hCUL1/Cyst:1

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hCUL1 forms found in complexes   

hCUL1 Component
 Complexes
PR:Q13616 hCUL1 PR:000026771 SCF beta-TrCP complex (human)
PR:000026772 SCF(Skp2) complex (human)
PR:000037513 FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0008285 negative regulation of cell population proliferationPR:000036454 hCUL1/iso:1/Nedd:1 PMID:8681378
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic processPR:000036454 hCUL1/iso:1/Nedd:1 PMID:10713156; PMID:10921923
GO:0051726 regulation of cell cyclePR:000036454 hCUL1/iso:1/Nedd:1 PMID:8681378
GO:0097193 intrinsic apoptotic signaling pathwayPR:000036454 hCUL1/iso:1/Nedd:1 PMID:8681378

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005515 protein bindingPR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0019005 SCF ubiquitin ligase complexPR:000036454 hCUL1/iso:1/Nedd:1 PMID:10713156; PMID:10921923; PMID:17098746
NOT GO:0019005 SCF ubiquitin ligase complexPR:Q13616-1 hCUL1/iso:1 PMID:10713156; PMID:10921923; PMID:12504026