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Protein Ontology report - mothers against decapentaplegic homolog 2 isoform Long (human)
PR:Q15796-1 - http://purl.obolibrary.org/obo/PR_Q15796-1
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q15796-1   
  PRO namemothers against decapentaplegic homolog 2 isoform Long (human) 
  Synonyms
PRO-Short-label: EXACT:hSMAD2/iso:Long
Other: EXACT:mothers against decapentaplegic homolog 2 isoform 1 (human) | smad2 isoform 1 (human)
  Definition"A smad2 isoform Long that is encoded in the genome of human." [PRO:CNA] 
  PRO Categoryorganism-sequence 
  ParentPR:000000468 smad2 isoform Long
PR:Q15796 mothers against decapentaplegic homolog 2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q15796-1
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
organism-sequence


PR:Q15796-1 mothers against decapentaplegic homolog 2 isoform Long (human)
hSMAD2/iso:Long

organism-modification


PR:000025934 smad2 isoform Long phosphorylated 1 (human)
hSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000025935 smad2 isoform Long phosphorylated 2 (human)
hSMAD2/iso:Long/Phos:2
Yes
Yes
organism-modification


PR:000025936 smad2 isoform Long phosphorylated 3 (human)
hSMAD2/iso:Long/Phos:3
Yes
Yes
organism-modification


PR:000025937 smad2 isoform Long phosphorylated 4 (human)
hSMAD2/iso:Long/Phos:4
Yes
organism-modification


PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
Yes
organism-modification


PR:000045371 smad2 isoform Long unphosphorylated 1 (human)
hSMAD2/iso:Long/UnPhos:1
Yes
Yes
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hSMAD2/iso:Long forms found in complexes   

hSMAD2/iso:Long Component
 Complexes
PR:000025934 hSMAD2/iso:Long/Phos:1 PR:000025933 smad2-smad4 protein complex 1 (human)
PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:000025935 hSMAD2/iso:Long/Phos:2 PR:000025946 smad2-smad4 protein complex 3 (human)
PR:000025936 hSMAD2/iso:Long/Phos:3 PR:000025947 smad2-smad4 protein complex 4 (human)
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PR:000025952 smad2-smad4-ski protein complex 2 (human)
PR:000025965 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006355 regulation of DNA-templated transcriptionPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:15690394; PMID:9689110
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
PR:000036554 hSMAD2/iso:Long/AcPhos:1 PMID:17074756
GO:0007165 signal transductionPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:8752209; PMID:8980228; PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
PR:000025936 hSMAD2/iso:Long/Phos:3 PMID:11027280
PR:000036554 hSMAD2/iso:Long/AcPhos:1 PMID:17074756
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:8752209; PMID:8980228
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PMID:8752209
GO:0060395 SMAD protein signal transductionPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
PR:000025936 hSMAD2/iso:Long/Phos:3 PMID:11027280

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:8980228; PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
GO:0003712 transcription coregulator activityPR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
GO:0003713 transcription coactivator activityPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9689110
NOT GO:0003713 transcription coactivator activityPR:000025936 hSMAD2/iso:Long/Phos:3 PMID:11027280
PR:000025937 hSMAD2/iso:Long/Phos:4 PMID:10197981
GO:0005515 protein bindingPR:000045371 hSMAD2/iso:Long/UnPhos:1 PMID:8980228
GO:0046332 SMAD bindingPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9311995
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595
PR:000025936 hSMAD2/iso:Long/Phos:3 PMID:11027280

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005634 nucleusPR:000025934 hSMAD2/iso:Long/Phos:1 PMID:9006934; PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2 PMID:12193595; PMID:17074053
PR:000036554 hSMAD2/iso:Long/AcPhos:1 PMID:17074756
GO:0005737 cytoplasmPR:000025936 hSMAD2/iso:Long/Phos:3 PMID:11027280
PR:000025937 hSMAD2/iso:Long/Phos:4 PMID:10197981
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PMID:15280432; PMID:17074053
GO:0005769 early endosomePR:000045371 hSMAD2/iso:Long/UnPhos:1 PMID:12356868