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Protein Ontology report - mothers against decapentaplegic homolog 2 isoform Short (human)
PR:Q15796-2 - http://purl.obolibrary.org/obo/PR_Q15796-2
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q15796-2   
  PRO namemothers against decapentaplegic homolog 2 isoform Short (human) 
  Synonyms
PRO-Short-label: EXACT:hSMAD2/iso:Short
Other: EXACT:mothers against decapentaplegic homolog 2 isoform 2 (human) | mothers against decapentaplegic homolog 2 isoform Smad2Deltaexon3 (human) | smad2 isoform 2 (human)
  Definition"A smad2 isoform Short that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15796] 
  PRO Categoryorganism-sequence 
  ParentPR:000000469 smad2 isoform Short
PR:Q15796 mothers against decapentaplegic homolog 2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q15796-2
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
organism-sequence


PR:Q15796-2
mothers against decapentaplegic homolog 2 isoform Short (human)
hSMAD2/iso:Short
"A smad2 isoform Short that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15796]

organism-modification


PR:000025938
smad2 isoform Short phosphorylated 1 (human)
hSMAD2/iso:Short/Phos:1
"A smad2 isoform Short phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046." [PRO:CNA]
Yes
Yes
organism-modification


PR:000036556
smad2 isoform Short acetylated and phosphorylated 1 (human)
hSMAD2/iso:Short/AcPhos:1
"A smad2 isoform Short acetylated and phosphorylated 1 in human. UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046." [PMID:17074756, PRO:CNA]
Yes
organism-modification


PR:000045494
smad2 isoform Short unphosphorylated 1 (human)
hSMAD2/iso:Short/UnPhos:1
"A mothers against decapentaplegic homolog 2 isoform Short (human) that lacks phosphorylation on the last two Ser of the C-terminal SSxS motif. UniProtKB:Q15796-2, Ser-435/Ser-437, PR:000026291." [PRO:CNA]

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hSMAD2/iso:Short forms found in complexes   

hSMAD2/iso:Short Component
 Complexes
PR:000025938 hSMAD2/iso:Short/Phos:1 PR:000025940 smad2-smad4 protein complex 2 (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025938 hSMAD2/iso:Short/Phos:1
UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:9873005
enablesGO:0003677 DNA binding PMID:14701940; PMID:9873005
GO:0003700 DNA-binding transcription factor activity PMID:9873005
GO:0003712 transcription coregulator activity PMID:14701940; PMID:9873005
PR:000036556 hSMAD2/iso:Short/AcPhos:1
UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756
enablesGO:0003677 DNA binding PMID:17074756
increased GO:0003700 DNA-binding transcription factor activity relative to PR:000000656 SMAD2/iso:Short/Phos:1 PMID:17074756