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Protein Ontology report - presenilin-2 (mouse)
PR:Q61144 - http://purl.obolibrary.org/obo/PR_Q61144
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q61144   
  PRO namepresenilin-2 (mouse) 
  Synonyms
PRO-Short-label: EXACT:mPSEN2
Gene-based: RELATED:Ad4h | Alg3 | Ps-2 | Psen2 | Psnl2
  Definition"A presenilin-2 that is encoded in the genome of mouse." [OMA:Q61144, PRO:CNA] 
  PRO Categoryorganism-gene 
  ParentPR:000013345 presenilin-2
PR:000029032 Mus musculus protein
  Gene TemplateMGI:109284 Psen2 (mouse)
  TaxonNCBITaxon:10090 Mus musculus
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q61144
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
organism-gene


PR:Q61144 presenilin-2 (mouse)
mPSEN2

union


PR:000036891 PS2s (mouse)
mPS2s

organism-sequence


PR:000036858 presenilin-2 isoform PS2short (mouse)
mPSEN2/iso:PS2short

organism-modification


PR:000036890 presenilin-2 isoform 1 CTF subunit (mouse)
mPSEN2/iso:1/Clv:CTF

organism-sequence


PR:000036858 presenilin-2 isoform PS2short (mouse)
mPSEN2/iso:PS2short
Yes
organism-sequence


PR:Q61144-1 presenilin-2 isoform 1 (mouse)
mPSEN2/iso:1

organism-modification


PR:000036886 presenilin-2 isoform 1 C-terminal fragment (mouse)
mPSEN2/iso:1/Clv:Cter

organism-modification


PR:000036888 presenilin-2 isoform 1 N-terminal fragment (mouse)
mPSEN2/iso:1/Clv:Nter

organism-modification


PR:000036890 presenilin-2 isoform 1 CTF subunit (mouse)
mPSEN2/iso:1/Clv:CTF

organism-sequence


PR:Q61144-2 presenilin-2 isoform PS2beta (mouse)
mPSEN2/iso:PS2beta
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036858 mPSEN2/iso:PS2short
UniProtKB:Q61144-1, 298-448		 acts_upstream_of_or_withinGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors MGI_ref:1099227; PMID:9353287
PR:Q61144-2 mPSEN2/iso:PS2beta
The sequence is shorter (361 residues long) than isoform 1 sharing the same sequence up to residue 357, followed by the sequence SKGA		 acts_upstream_of_or_withinGO:0031333 negative regulation of protein-containing complex assembly MGI_ref:3843380; PMID:19376115
GO:0032091 negative regulation of protein binding MGI_ref:3843380; PMID:19376115
located_inGO:0005783 endoplasmic reticulum MGI_ref:3843380; PMID:19376115