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Protein Ontology report - cochlin (mouse)
PR:Q62507 - http://purl.obolibrary.org/obo/PR_Q62507
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q62507   
  PRO namecochlin (mouse) 
  Synonyms
PRO-Short-label: EXACT:mCOCH
Gene-based: RELATED:Coch
Other: EXACT:COCH-5B2 (mouse)
  Definition"A cochlin that is encoded in the genome of mouse." [OMA:Q62507, PRO:DNx] 
  PRO Categoryorganism-gene 
  ParentPR:000005683 cochlin
PR:000029032 Mus musculus protein
  Gene TemplateMGI:1278313 Coch (mouse)
  TaxonNCBITaxon:10090 Mus musculus
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q62507
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
organism-gene



PR:Q62507

cochlin (mouse)

mCOCH


"A cochlin that is encoded in the genome of mouse." [OMA:Q62507, PRO:DNx]


union



PR:000037266

cochlin N-terminal fragment (mouse)

mCOCH/Nter


"A cochlin (mouse) that consists of the region upstream of LCCL domain (Pfam:PF03815) without the signal peptide. The fragment may or may not be glycosylated." [PMID:23684986, PRO:KRC]

Yes

organism-modification



PR:000037261

cochlin p8 (mouse)

mCOCH/Clv:p8


"A cochlin, signal peptide removed form (mouse) that results from cleavage downstream of the LCCL domain (Pfam:PF03815) by aggrecanases proteolytic activity. This form results from the deglycosylation of the N-terminal fragment p18. UniProtKB:Q62507, 26-134." [PMID:23684986, PRO:KRC]


organism-modification



PR:000037262

cochlin p18 (mouse)

mCOCH/Clv:p18


"A cochlin, signal peptide removed form (mouse) that results from cleavage downstream of the LCCL domain (Pfam:PF03815), and includes at least one glycosylated residue. UniProtKB:Q62507, 26-134, MOD:00693." [PMID:23684986, PRO:KRC]


organism-modification



PR:000037260

cochlin, signal peptide removed form (mouse)

mCOCH/SigPep-


"A cochlin (mouse) that the signal peptide has been removed. UniProtKB:Q62507, 27-552." [PMID:23684986, PRO:KRC]

Yes

organism-modification



PR:000037261

cochlin p8 (mouse)

mCOCH/Clv:p8


"A cochlin, signal peptide removed form (mouse) that results from cleavage downstream of the LCCL domain (Pfam:PF03815) by aggrecanases proteolytic activity. This form results from the deglycosylation of the N-terminal fragment p18. UniProtKB:Q62507, 26-134." [PMID:23684986, PRO:KRC]

Yes

organism-modification



PR:000037263

cochlin p40 (mouse)

mCOCH/Clv:p40


"A cochlin, signal peptide removed form (mouse) that results from further cleavage of the LCCL domain (Pfam:PF03815) after aggrecanases proteolytic activity. UniProtKB:Q62507, 135-552." [PMID:23684986, PRO:KRC]

Yes

organism-modification



PR:000037264

cochlin, signal peptide removed glycosylated form (mouse)

mCOCH/SigPep-/GlycoRes+


"A cochlin, signal peptide removed form (mouse) that includes at least one glycosylated residue. UniProtKB:Q62507, 26-552, MOD:00693." [PMID:23684986, PRO:KRC]


organism-modification



PR:000037262

cochlin p18 (mouse)

mCOCH/Clv:p18


"A cochlin, signal peptide removed form (mouse) that results from cleavage downstream of the LCCL domain (Pfam:PF03815), and includes at least one glycosylated residue. UniProtKB:Q62507, 26-134, MOD:00693." [PMID:23684986, PRO:KRC]

Yes

organism-modification



PR:000037265

cochlin precursor (mouse)

mCOCH/precursor


"A cochlin (mouse) that has not been subjected to any proteolytic cleavage. UniProtKB:Q62507, 1-552." [PMID:23684986, PRO:KRC]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0042742 defense response to bacteriumPR:000037266 mCOCH/Nter MGI_ref:5525040; PMID:23684986
GO:0045089 positive regulation of innate immune responsePR:000037266 mCOCH/Nter MGI_ref:5525040; PMID:23684986

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005576 extracellular regionPR:000037261 mCOCH/Clv:p8 MGI_ref:5525040; PMID:23684986
PR:000037262 mCOCH/Clv:p18 MGI_ref:5525040; PMID:23684986
GO:0031012 extracellular matrixPR:000037260 mCOCH/SigPep- MGI_ref:5525040; PMID:23684986
PR:000037263 mCOCH/Clv:p40 MGI_ref:5525040; PMID:23684986