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Protein Ontology report - pro-neuregulin-1, membrane-bound isoform (mouse)
PR:Q6DR98 - http://purl.obolibrary.org/obo/PR_Q6DR98
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q6DR98   
  PRO namepro-neuregulin-1, membrane-bound isoform (mouse) 
  Synonyms
PRO-Short-label: EXACT:mNRG1
Gene-based: NARROW:Nrg1
Other: EXACT:pro-NRG1 (mouse)
  Definition"A pro-neuregulin-1, membrane-bound isoform that is encoded in the genome of mouse." [PRO:KRC] 
  PRO Categoryorganism-gene 
  ParentPR:000029032 Mus musculus protein
PR:000029649 pro-neuregulin-1, membrane-bound isoform
  Gene TemplateMGI:96083 Nrg1 (mouse)
  TaxonNCBITaxon:10090 Mus musculus
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 9                                        
         Modification0                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q6DR98
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
organism-gene



PR:Q6DR98

pro-neuregulin-1, membrane-bound isoform (mouse)

mNRG1


"A pro-neuregulin-1, membrane-bound isoform that is encoded in the genome of mouse." [PRO:KRC]

Yes

organism-sequence



PR:000044837

neuregulin-1 type I-beta4a (mouse)

mNRG1/iso:Ibeta4a


"A pro-neuregulin-1, membrane-bound isoform (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein described as NRG type I-beta4 in PMID:11116142." [PMID:11116142, PRO:KRC]


organism-modification



PR:000044838

neuregulin-1 type I-beta4a transmembrane precursor (mouse)

mNRG1/iso:Ibeta4a/precursor


"A neuregulin-1 type I-beta4a (mouse) that has not been proteolytically processed." [PMID:11116142, PRO:KRC]


organism-modification



PR:000044839

neuregulin-1 type I-beta4a mature form (mouse)

mNRG1/iso:Ibeta4a/mature


"A neuregulin-1 type I-beta4a (mouse) that has been proteolytically processed by the Meltrin beta/ADAM19 metalloprotease to produced a soluble form consisting of the ectodomain." [PMID:11116142, PRO:KRC]


union



PR:000044840

neuregulin-1 type III (mouse)

mNRG1/iso:III


"A pro-neuregulin-1, membrane-bound isoform (mouse) that has an N-terminal cysteine-rich domain (CRD)." [PMID:15044753, PRO:KRC]

Yes





PR:A0A140LIG9

neuregulin-1 type III-beta1c (mouse)











PR:A0A5F8MPT0

neuregulin-1 type III-beta3 (mouse)











PR:Q6DR99

neuregulin-1 type III-beta1a (mouse)







organism-sequence



PR:A0A140LIG9

neuregulin-1 type III-beta1c (mouse)

mNRG1/iso:IIIbeta1c


"A neuregulin-1 type III-beta1c that is encoded in the genome of mouse." [PMID:12648463, PMID:24083437, PRO:DAN, PRO:KRC]


organism-sequence



PR:Q3URY7

neuregulin-1 type III-beta1c sequence variant S499Y (mouse)

mNRG1/iso:IIIbeta1c/var:S499Y


"A neuregulin-1 type III-beta1c (mouse) that has a Tyr residue at the position equivalent to Ser-499 of the amino acid sequence represented by UniProtKB:A0A140LIG9. UniProtKB:A0A140LIG9, Ser-499, CHEBI:46858." [PRO:DAN]


organism-modification



PR:000044825

neuregulin-1 type III-beta1c transmembrane precursor (mouse)

mNRG1/iso:IIIbeta1c/precursor


"A neuregulin-1 type III-beta1c (mouse) that has not been proteolytically processed." [PMID:12648463, PMID:24083437, PRO:KRC]


organism-sequence



PR:A0A140LIP8

neuregulin-1 type beta2 (mouse)

mNRG1/iso:beta2


"A neuregulin-1 type beta2 that is encoded in the genome of mouse." [PRO:DAN]


organism-sequence



PR:A0A140LJC1

neuregulin-1 type I-alpha2a (mouse)

mNRG1/iso:Ialpha2a


"A neuregulin-1 type I-alpha2a that is encoded in the genome of mouse." [PMID:11116142, PRO:DAN, PRO:KRC]


organism-modification



PR:000044842

neuregulin-1 type I-alpha2a transmembrane precursor (mouse)

mNRG1/iso:Ialpha2a/precursor


"A neuregulin-1 type I-alpha2a (mouse) that has not been proteolytically processed." [PMID:11116142, PRO:KRC]


organism-sequence



PR:A0A5F8MPT0

neuregulin-1 type III-beta3 (mouse)

mNRG1/iso:IIIbeta3


"A neuregulin-1 type III-beta3 that is encoded in the genome of mouse." [PMID:12648463, PMID:24083437, PRO:KRC]


organism-sequence



PR:Q8BX76

neuregulin-1 type III-beta3 sequence variant D40N (mouse)

mNRG1/iso:IIIbeta3/var:D40N


"A neuregulin-1 type III-beta3 (mouse) that has an Asn residue at the position equivalent to Asp-40 of the amino acid sequence represented by UniProtKB:A0A5F8MPT0. UniProtKB:A0A5F8MPT0, Asp-40, CHEBI:50347." [PRO:DAN]


organism-sequence



PR:Q6DR98-1

neuregulin-1 type I-beta1a (mouse)

mNRG1/iso:Ibeta1a


"A neuregulin-1 type I-beta1a that is encoded in the genome of mouse." [PMID:11116142, PRO:KRC]


organism-modification



PR:000044821

neuregulin-1 type I-beta1a mature form (mouse)

mNRG1/iso:Ibeta1a/mature


"A neuregulin-1 type I-beta1a (mouse) that has been proteolytically processed by the Meltrin beta/ADAM19 metalloprotease to produce a soluble form consisting of the ectodomain." [PMID:11116142, PRO:KRC]

Yes

organism-modification



PR:000044823

neuregulin-1 type I-beta1a transmembrane precursor (mouse)

mNRG1/iso:Ibeta1a/precursor


"A neuregulin-1 type I-beta1a (mouse) that has not been proteolytically processed." [PMID:11116142, PRO:KRC]


organism-sequence



PR:Q6DR99

neuregulin-1 type III-beta1a (mouse)

mNRG1/iso:IIIbeta1a


"A pro-neuregulin-1, membrane-bound isoform (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6DR99." [PMID:12648463, PMID:24083437, PRO:KRC, UniProtKB:Q6DR99]

Yes

organism-modification



PR:000044824

neuregulin-1 type III-beta1a transmembrane precursor (mouse)

mNRG1/iso:IIIbeta1a/precursor


"A neuregulin-1 type III-beta1a (mouse) that has not been proteolytically processed." [PMID:12648463, PMID:24083437, PRO:KRC, UniProtKB:Q6DR99]

Yes

organism-modification



PR:000044843

neuregulin-1 intracellular domain (mouse)

mNRG1/Clv:intracellular


"A pro-neuregulin-1, membrane-bound isoform (mouse) that corresponds to the intracellular domain after proteolytic cleavage. Example: UniProtKB:Q6DR99, 326-700." [PMID:20610754, PMID:24083437, PRO:KRC]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000044821 mNRG1/iso:Ibeta1a/mature acts_upstream_of_or_withinGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation MGI_ref:3625788; PMID:11116142
located_inGO:0005576 extracellular region MGI_ref:3625788; PMID:11116142
PR:000044824 mNRG1/iso:IIIbeta1a/precursor acts_upstream_of_or_withinGO:0045773 positive regulation of axon extension MGI_ref:4461331; PMID:20610754
PR:000044840 mNRG1/iso:III acts_upstream_of_or_withinGO:0001964 startle response MGI_ref:3803029; PMID:18596162
GO:0008366 axon ensheathment MGI_ref:3590355; PMID:16129398
GO:0031643 positive regulation of myelination MGI_ref:4420197; PMID:18080294
GO:0031643 positive regulation of myelination MGI_ref:4420197; PMID:18080294
NOT GO:0048709 oligodendrocyte differentiation MGI_ref:4420197; PMID:18080294
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction MGI_ref:3796800; PMID:18458158
GO:0060999 positive regulation of dendritic spine development MGI_ref:4461331; PMID:20610754
GO:0060999 positive regulation of dendritic spine development MGI_ref:4461331; PMID:20610754
GO:2000010 positive regulation of protein localization to cell surface MGI_ref:3796800; PMID:18458158
located_inGO:0030424 axon MGI_ref:4461331; PMID:20610754
GO:0030424 axon MGI_ref:4461331; PMID:20610754
GO:0030425 dendrite MGI_ref:4461331; PMID:20610754
GO:0030673 axolemma MGI_ref:3796800; PMID:18458158
GO:0044297 cell body MGI_ref:4461331; PMID:20610754
PR:000044843 mNRG1/Clv:intracellular
Example: UniProtKB:Q6DR99, 326-700
acts_upstream_of_or_withinGO:0022008 neurogenesis MGI_ref:4438553; PMID:19781646
GO:0022008 neurogenesis MGI_ref:4438553; PMID:19781646
NOT GO:0045773 positive regulation of axon extension MGI_ref:4461331; PMID:20610754
GO:0045944 positive regulation of transcription by RNA polymerase II MGI_ref:4461331; PMID:20610754
enablesGO:0005515 protein binding with PR:O54941 Baf57 MGI_ref:4438553; PMID:19781646
located_inGO:0005634 nucleus MGI_ref:4461331; PMID:20610754
PR:Q6DR98 mNRG1 acts_upstream_of_or_withinNOT GO:0031643 positive regulation of myelination MGI_ref:3042336; PMID:15044753
located_inGO:0009897 external side of plasma membrane MGI_ref:3625788; PMID:11116142
PR:Q6DR99 mNRG1/iso:IIIbeta1a acts_upstream_of_or_withinGO:0031643 positive regulation of myelination MGI_ref:3042336; PMID:15044753