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Documentation
Protein Ontology report - pro-neuregulin-1, membrane-bound isoform (mouse)
PR:Q6DR98 -
http://purl.obolibrary.org/obo/PR_Q6DR98
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:Q6DR98
PRO name
pro-neuregulin-1, membrane-bound isoform (mouse)
Synonyms
PRO-Short-label
:
EXACT:
mNRG1
Gene-based
:
NARROW:
Nrg1
Other
:
EXACT:
pro-NRG1 (mouse)
Definition
"A pro-neuregulin-1, membrane-bound isoform that is encoded in the genome of mouse." [PRO:KRC]
PRO Category
organism-gene
Parent
PR:000029032
Mus musculus protein
PR:000029649
pro-neuregulin-1, membrane-bound isoform
Gene Template
MGI:96083
Nrg1 (mouse)
Taxon
NCBITaxon:10090
Mus musculus
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
9
Modification
0
Organism-Modification
8
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:Q6DR98
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
organism-gene
PR:Q6DR98
pro-neuregulin-1, membrane-bound isoform (mouse)
mNRG1
"A pro-neuregulin-1, membrane-bound isoform that is encoded in the genome of mouse." [PRO:KRC]
Yes
organism-sequence
PR:000044837
neuregulin-1 type I-beta4a (mouse)
mNRG1/iso:Ibeta4a
"A pro-neuregulin-1, membrane-bound isoform (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein described as NRG type I-beta4 in PMID:11116142." [PMID:11116142, PRO:KRC]
organism-modification
PR:000044838
neuregulin-1 type I-beta4a transmembrane precursor (mouse)
mNRG1/iso:Ibeta4a/precursor
"A neuregulin-1 type I-beta4a (mouse) that has not been proteolytically processed." [PMID:11116142, PRO:KRC]
organism-modification
PR:000044839
neuregulin-1 type I-beta4a mature form (mouse)
mNRG1/iso:Ibeta4a/mature
"A neuregulin-1 type I-beta4a (mouse) that has been proteolytically processed by the Meltrin beta/ADAM19 metalloprotease to produced a soluble form consisting of the ectodomain." [PMID:11116142, PRO:KRC]
union
PR:000044840
neuregulin-1 type III (mouse)
mNRG1/iso:III
"A pro-neuregulin-1, membrane-bound isoform (mouse) that has an N-terminal cysteine-rich domain (CRD)." [PMID:15044753, PRO:KRC]
Yes
PR:A0A140LIG9
neuregulin-1 type III-beta1c (mouse)
PR:A0A5F8MPT0
neuregulin-1 type III-beta3 (mouse)
PR:Q6DR99
neuregulin-1 type III-beta1a (mouse)
organism-sequence
PR:A0A140LIG9
neuregulin-1 type III-beta1c (mouse)
mNRG1/iso:IIIbeta1c
"A neuregulin-1 type III-beta1c that is encoded in the genome of mouse." [PMID:12648463, PMID:24083437, PRO:DAN, PRO:KRC]
organism-sequence
PR:Q3URY7
neuregulin-1 type III-beta1c sequence variant S499Y (mouse)
mNRG1/iso:IIIbeta1c/var:S499Y
"A neuregulin-1 type III-beta1c (mouse) that has a Tyr residue at the position equivalent to Ser-499 of the amino acid sequence represented by UniProtKB:A0A140LIG9. UniProtKB:A0A140LIG9, Ser-499, CHEBI:46858." [PRO:DAN]
organism-modification
PR:000044825
neuregulin-1 type III-beta1c transmembrane precursor (mouse)
mNRG1/iso:IIIbeta1c/precursor
"A neuregulin-1 type III-beta1c (mouse) that has not been proteolytically processed." [PMID:12648463, PMID:24083437, PRO:KRC]
organism-sequence
PR:A0A140LIP8
neuregulin-1 type beta2 (mouse)
mNRG1/iso:beta2
"A neuregulin-1 type beta2 that is encoded in the genome of mouse." [PRO:DAN]
organism-sequence
PR:A0A140LJC1
neuregulin-1 type I-alpha2a (mouse)
mNRG1/iso:Ialpha2a
"A neuregulin-1 type I-alpha2a that is encoded in the genome of mouse." [PMID:11116142, PRO:DAN, PRO:KRC]
organism-modification
PR:000044842
neuregulin-1 type I-alpha2a transmembrane precursor (mouse)
mNRG1/iso:Ialpha2a/precursor
"A neuregulin-1 type I-alpha2a (mouse) that has not been proteolytically processed." [PMID:11116142, PRO:KRC]
organism-sequence
PR:A0A5F8MPT0
neuregulin-1 type III-beta3 (mouse)
mNRG1/iso:IIIbeta3
"A neuregulin-1 type III-beta3 that is encoded in the genome of mouse." [PMID:12648463, PMID:24083437, PRO:KRC]
organism-sequence
PR:Q8BX76
neuregulin-1 type III-beta3 sequence variant D40N (mouse)
mNRG1/iso:IIIbeta3/var:D40N
"A neuregulin-1 type III-beta3 (mouse) that has an Asn residue at the position equivalent to Asp-40 of the amino acid sequence represented by UniProtKB:A0A5F8MPT0. UniProtKB:A0A5F8MPT0, Asp-40, CHEBI:50347." [PRO:DAN]
organism-sequence
PR:Q6DR98-1
neuregulin-1 type I-beta1a (mouse)
mNRG1/iso:Ibeta1a
"A neuregulin-1 type I-beta1a that is encoded in the genome of mouse." [PMID:11116142, PRO:KRC]
organism-modification
PR:000044821
neuregulin-1 type I-beta1a mature form (mouse)
mNRG1/iso:Ibeta1a/mature
"A neuregulin-1 type I-beta1a (mouse) that has been proteolytically processed by the Meltrin beta/ADAM19 metalloprotease to produce a soluble form consisting of the ectodomain." [PMID:11116142, PRO:KRC]
Yes
organism-modification
PR:000044823
neuregulin-1 type I-beta1a transmembrane precursor (mouse)
mNRG1/iso:Ibeta1a/precursor
"A neuregulin-1 type I-beta1a (mouse) that has not been proteolytically processed." [PMID:11116142, PRO:KRC]
organism-sequence
PR:Q6DR99
neuregulin-1 type III-beta1a (mouse)
mNRG1/iso:IIIbeta1a
"A pro-neuregulin-1, membrane-bound isoform (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q6DR99." [PMID:12648463, PMID:24083437, PRO:KRC, UniProtKB:Q6DR99]
Yes
organism-modification
PR:000044824
neuregulin-1 type III-beta1a transmembrane precursor (mouse)
mNRG1/iso:IIIbeta1a/precursor
"A neuregulin-1 type III-beta1a (mouse) that has not been proteolytically processed." [PMID:12648463, PMID:24083437, PRO:KRC, UniProtKB:Q6DR99]
Yes
organism-modification
PR:000044843
neuregulin-1 intracellular domain (mouse)
mNRG1/Clv:intracellular
"A pro-neuregulin-1, membrane-bound isoform (mouse) that corresponds to the intracellular domain after proteolytic cleavage. Example: UniProtKB:Q6DR99, 326-700." [PMID:20610754, PMID:24083437, PRO:KRC]
Yes
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Functional Annotation (GO-centric view)
Switch to
PRO Centric View
Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0001964
startle response
PR:000044840
mNRG1/iso:III
MGI_ref:3803029;
PMID:18596162
GO:0008366
axon ensheathment
PR:000044840
mNRG1/iso:III
MGI_ref:3590355;
PMID:16129398
GO:0022008
neurogenesis
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
GO:0031643
positive regulation of myelination
PR:000044840
mNRG1/iso:III
MGI_ref:4420197;
PMID:18080294
PR:000044840
mNRG1/iso:III
MGI_ref:4420197;
PMID:18080294
PR:Q6DR99
mNRG1/iso:IIIbeta1a
MGI_ref:3042336;
PMID:15044753
NOT
GO:0031643
positive regulation of myelination
PR:Q6DR98
mNRG1
MGI_ref:3042336;
PMID:15044753
GO:0045773
positive regulation of axon extension
PR:000044824
mNRG1/iso:IIIbeta1a/precursor
MGI_ref:4461331;
PMID:20610754
NOT
GO:0045773
positive regulation of axon extension
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4461331;
PMID:20610754
GO:0045944
positive regulation of transcription by RNA polymerase II
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4461331;
PMID:20610754
NOT
GO:0048709
oligodendrocyte differentiation
PR:000044840
mNRG1/iso:III
MGI_ref:4420197;
PMID:18080294
GO:0050731
positive regulation of peptidyl-tyrosine phosphorylation
PR:000044821
mNRG1/iso:Ibeta1a/mature
MGI_ref:3625788;
PMID:11116142
GO:0051897
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
PR:000044840
mNRG1/iso:III
MGI_ref:3796800;
PMID:18458158
GO:0060999
positive regulation of dendritic spine development
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
GO:2000010
positive regulation of protein localization to cell surface
PR:000044840
mNRG1/iso:III
MGI_ref:3796800;
PMID:18458158
Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005515
protein binding
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4438553;
PMID:19781646
Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005576
extracellular region
PR:000044821
mNRG1/iso:Ibeta1a/mature
MGI_ref:3625788;
PMID:11116142
GO:0005634
nucleus
PR:000044843
mNRG1/Clv:intracellular
MGI_ref:4461331;
PMID:20610754
GO:0009897
external side of plasma membrane
PR:Q6DR98
mNRG1
MGI_ref:3625788;
PMID:11116142
GO:0030424
axon
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
GO:0030425
dendrite
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754
GO:0030673
axolemma
PR:000044840
mNRG1/iso:III
MGI_ref:3796800;
PMID:18458158
GO:0044297
cell body
PR:000044840
mNRG1/iso:III
MGI_ref:4461331;
PMID:20610754