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Protein Ontology report - mothers against decapentaplegic homolog 3 isoform 1 (mouse)
PR:Q8BUN5-1 -
http://purl.obolibrary.org/obo/PR_Q8BUN5-1
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:Q8BUN5-1
PRO name
mothers against decapentaplegic homolog 3 isoform 1 (mouse)
Synonyms
PRO-Short-label
:
EXACT:
mSMAD3/iso:1
Definition
"A smad3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
PRO Category
organism-sequence
Parent
PR:000000475
smad3 isoform 1
PR:Q8BUN5
mothers against decapentaplegic homolog 3 (mouse)
Taxon
NCBITaxon:10090
Mus musculus
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
0
Organism-Sequence
1
Modification
0
Organism-Modification
3
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:Q8BUN5-1
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
comp.
In Complex?
organism-sequence
PR:Q8BUN5-1
mothers against decapentaplegic homolog 3 isoform 1 (mouse)
mSMAD3/iso:1
"A smad3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification
PR:000036558
smad3 isoform 1 phosphorylated 1 (mouse)
mSMAD3/iso:1/Phos:1
"A smad3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046." [PMID:10823886, PMID:12943993, PMID:15282343, PMID:15464984, PMID:9702197, PRO:CNA]
Yes
organism-modification
PR:000036560
smad3 isoform 1 phosphorylated 2 (mouse)
mSMAD3/iso:1/Phos:2
"A smad3 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000036561
smad3 isoform 1 phosphorylated 3 (mouse)
mSMAD3/iso:1/Phos:3
"A smad3 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PMID:10197981, PRO:CNA, PRO:DAN]
Yes
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036558
mSMAD3/iso:1/Phos:1
UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046
enables
GO:0003690
double-stranded DNA binding
PMID:15282343
GO:0003700
DNA-binding transcription factor activity
PMID:10823886
;
PMID:12943993
GO:0008134
transcription factor binding
PMID:15464984
;
PMID:9702197
located_in
GO:0005634
nucleus
PMID:12943993
;
PMID:15282343
GO:0005667
transcription factor complex
PMID:9702197
PR:000036560
mSMAD3/iso:1/Phos:2
UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046
enables
decreased
GO:0003700
DNA-binding transcription factor activity
relative to
PR:000036558
mSMAD3/iso:1/Phos:1
PMID:15241418
PR:000036561
mSMAD3/iso:1/Phos:3
UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046
enables
NOT
GO:0003713
transcription coactivator activity
PMID:10197981
located_in
GO:0005737
cytoplasm
PMID:10197981
PR:Q8BUN5-1
mSMAD3/iso:1
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:12543979
enables
GO:0005515
protein binding
with
PR:000036434
mTGFBR1/iso:1/SigPep-/Phos:1
PMID:12154125
GO:0005515
protein binding
with
PR:A2A8R0
mZFYVE9/iso:1
PMID:12154125
