Protein Ontology

Home

Linked Open Data

Browse

Statistics

Download

RACE-PRO

PRO tracker

Community

PRO Consortium

Publications

Documentation

Protein Ontology report - CREB-binding protein (human)

PR:Q92793 - http://purl.obolibrary.org/obo/PR_Q92793

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PAF

GPI

PRO ID

PR:Q92793

PRO name

CREB-binding protein (human)

Synonyms

PRO-Short-label:	EXACT:	hCREBBP
Gene-based:	RELATED:	CBP \| CREBBP
Other:	EXACT:	histone lysine acetyltransferase CREBBP (human) \| protein-lysine acetyltransferase CREBBP (human)

Definition

"A CREB-binding protein that is encoded in the genome of human." [PMID:11331617]

PRO Category

organism-gene

Parent

PR:000000090 CREB-binding protein
PR:000027108 transcription adapter with TAZ, KIX and bromo-domains (human)

Gene Template

HGNC:2348 CREBBP (human)

Taxon

NCBITaxon:9606 Homo sapiens

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	0	Organism-Gene	1
Sequence	0	Organism-Sequence	3
Modification	0	Organism-Modification	3

Term Hierarchy
Visualization

DAG:

OLS:

Back to top

Related Cross References
Db identifiers	UniProtKB:Q92793

Back to top

Protein Forms

Switch to Extended View

Category

PRO Form Name

Short Name

Ann. Has Annotation?

comp. In Complex?

organism-gene

PR:Q92793 CREB-binding protein (human)

hCREBBP

organism-sequence

PR:000000266 CREB-binding protein sequence variant R1378P (human)

hCREBBP/var:R1378P

Yes

organism-sequence

PR:Q92793-1 CREB-binding protein isoform 1 (human)

hCREBBP/iso:1

Yes

organism-sequence

PR:Q92793-2 CREB-binding protein isoform h2 (human)

hCREBBP/iso:h2

organism-modification

PR:000064816 CREB-binding protein sumoylated 1 (human)

hCREBBP/Sumo:1

organism-modification

PR:000067783 CREB-binding protein phosphorylated 1 (human)

hCREBBP/Phos:1

organism-modification

PR:000080126 CREB-binding protein phosphorylated 2 (human)

hCREBBP/Phos:2

Back to top

Functional Annotation (PRO-centric view)

Switch to GO Centric View

PRO Term	GO Annotation		Evidence
PR:000000266 hCREBBP/var:R1378P Example: UniProtKB:Q92793-1, Arg-1378, CHEBI:50342	associated_with_disease_progression	DO:1933 Rubinstein-Taybi syndrome	PMID:11331617
	enables	NOT GO:0004402 histone acetyltransferase activity	PMID:11331617
	located_in	SO:0001559 polypeptide_loss_of_function_variant	PMID:11331617
PR:Q92793-1 hCREBBP/iso:1	acts_upstream_of_or_within	GO:0006355 regulation of DNA-templated transcription	PMID:12169688; PMID:7913207
	acts_upstream_of_or_within	GO:0045893 positive regulation of DNA-templated transcription	PMID:11742995
	enables	GO:0003713 transcription coactivator activity	PMID:10733899; PMID:10893273; PMID:12169688; PMID:12586840; PMID:8684459
		GO:0004402 histone acetyltransferase activity	PMID:11742995
		GO:0005515 protein binding with PR:P42858 HD	PMID:11799127
		GO:0005515 protein binding with PR:P55209 hNAP1L1	PMID:11799127
		GO:0005515 protein binding with PR:Q04206 hRELA	PMID:11799127
		GO:0005515 protein binding with PR:Q14686 activating signal cointegrator 2 (human)	PMID:11799127
		GO:0005515 protein binding with PR:Q16665 ARNT-interacting protein (human)	PMID:11799127
		GO:0005515 protein binding with PR:Q92793 CBP	PMID:11799127
		GO:0005515 protein binding with PR:Q99967-1	PMID:11799127
		GO:0005515 protein binding with PR:Q9UER7 BING2	PMID:11799127
		GO:0005515 protein binding	PMID:11799127
		GO:0005515 protein binding	PMID:11799127
		GO:0016407 acetyltransferase activity	PMID:11742995
	located_in	GO:0000123 histone acetyltransferase complex	PMID:9742083
	located_in	GO:0005634 nucleus	PMID:7913207