[Term]
id: PR:000026188
name: E3 ubiquitin-protein ligase CBL isoform 1 phosphorylated 1
def: "An E3 ubiquitin-protein ligase CBL isoform 1 that has been phosphorylated by tyrosine kinase receptors, such as EGFR or INSR. This tyrosine phosphorylation is necessary for activation of the ubiquitin ligase activity. Example: UniProtKB:P22681-1, Tyr-371, MOD:00048." [PRO:CNx, PMID:11997497, PMID:15117950, Reactome:R-HSA-182923, Reactome:R-HSA-182940]
comment: Category=modification.
synonym: "CBL/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "phospho-CLB" RELATED []
is_a: PR:000026186 ! E3 ubiquitin-protein ligase CBL isoform 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine