[Term]
id: PR:000028435
name: TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human)
def: "A death-inducing signaling complex in human that is composed of one molecule of caspase-8, three molecules of TNF receptor-associated factor 2, initiator methionine removed form, two molecules of FAS-associated death domain protein, one molecule of receptor-interacting serine/threonine-protein kinase 1, and three molecules of tumor necrosis factor receptor type 1-associated DEATH domain protein." [PRO:DAN, PRO:PDE, Reactome:R-HSA-140976]
comment: Category=organism-complex.
xref: Reactome:R-HSA-140976 "PR:000028435 located_in GO:0005829"
is_a: GO:0031264 ! death-inducing signaling complex
relationship: has_component PR:000028382 {cardinality="3"} ! TNF receptor-associated factor 2, initiator methionine removed form (human)
relationship: has_component PR:Q13158 {cardinality="2"} ! FAS-associated death domain protein (human)
relationship: has_component PR:Q14790 {cardinality="1"} ! caspase-8 (human)
relationship: has_component PR:Q13546 {cardinality="1"} ! receptor-interacting serine/threonine-protein kinase 1 (human)
relationship: has_component PR:Q15628 {cardinality="3"} ! tumor necrosis factor receptor type 1-associated DEATH domain protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens