[Term]
id: PR:000028547
name: NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1
def: "An NF-kappa-B inhibitor alpha isoform 1 that has been phosphorylated on the Ser residues in the motif KKx(8-11)SDGxxS and subsequently ubiquitinated on the Lys residues of the same motif. This modification targets the protein to proteosome degradation. Example: UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PRO:CNA, PMID:10329681, PMID:10837071]
comment: Category=modification.
synonym: "NFKBIA/iso:1/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "ubiquitinated phospho-IKb" RELATED []
is_a: PR:000028543 ! NF-kappa-B inhibitor alpha isoform 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:01148 ! ubiquitinylated lysine