[Term]
id: PR:000037358
name: IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
def: "An IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex whose components are encoded in the genome of human." [PRO:VS, PMID:14517278, PMID:14739303, PMID:16281057, Reactome:REACT_27000]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR3:TRIF:K63-poly-Ub-TRAF3:p-TBK1/p-IKK epsilon:IRF3" RELATED Reactome-displayName [Reactome:REACT_27000]
is_a: PR:000037357 ! IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex
relationship: has_component CHEBI:67208 {cardinality="1"} ! dsRNA
relationship: has_component PR:000036032 {cardinality="2"} ! TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
relationship: has_component PR:000037305 {cardinality="2"} ! Toll-like receptor 3, signal peptide removed form (human)
relationship: has_component PR:000028691 {cardinality="2"} ! inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1 (human)
relationship: has_component PR:000028702 {cardinality="2"} ! interferon regulatory factor 3 unmodified form (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)
relationship: has_component PR:Q13114 {cardinality="2"} ! TNF receptor-associated factor 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens