[Term]
id: PR:000050272
name: papain-like proteinase nsp3 (SARS-CoV-2)
def: "A rep gene proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the autocatalytic action of PL-PRO proteinase (nsp3) when it cleaves the precursor rep gene translation product (SARS-CoV-2) between residues 818-819 and 2763-2764." [PRO:DAN, GenPept:YP_009725299, UniProtKB:P0DTC1, UniProtKB:P0DTD1]
comment: Category=organism-modification. Note: 1945 aa protein. Unlike some other coronaviruses, SARS coronaviruses only encode a single papain-like proteinase, PLpro. [PMID:15564471]
synonym: "rep/Clv:nsp3 (SARS2)" EXACT PRO-short-label [PRO:DAN]
synonym: "main proteinase (SARS-CoV-2)" EXACT [PRO:DAN, UniProtKB:P0DTC1, UniProtKB:P0DTD1]
synonym: "non-structural protein 3 (SARS-CoV-2)" EXACT [UniProtKB:P0DTC1, UniProtKB:P0DTD1]
synonym: "nsp3 (SARS-CoV-2)" EXACT [UniProtKB:P0DTC1, UniProtKB:P0DTD1]
synonym: "PLpro (SARS-CoV-2)" EXACT [PRO:DAN, PMID:15564471]
synonym: "PRO_0000449621" EXACT PRO-proteoform-ftid [PRO:DAN]
synonym: "PRO_0000449637" EXACT PRO-proteoform-ftid [PRO:DAN]
synonym: "UniProtKB:P0DTC1, 819-2763" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "UniProtKB:P0DTD1, 819-2763" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "PL2-PRO (SARS-CoV-2)" RELATED [UniProtKB:P0DTC1, UniProtKB:P0DTD1]
xref: GenPept:YP_009725299
xref: GenPept:YP_009742610
is_a: PR:000050281 ! rep gene proteolytic cleavage product (SARS-CoV-2)
relationship: only_in_taxon NCBITaxon:2697049 ! Severe acute respiratory syndrome coronavirus 2