[Term]
id: PR:000064048
name: epidermal growth factor receptor sequence variant T263P, signal peptide removed phosphorylated 1 (human)
def: "An epidermal growth factor receptor (human) that has a Pro residue at the position equivalent to Thr-263 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Thr-263, CHEBI:50342|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1996336]
comment: Category=organism-modification.
synonym: "hEGFR/var:T263P/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "p-6Y-EGFR T263P" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-1996336]
synonym: "UniProtKB:P00533, 25-1210, Thr-263, CHEBI:50342|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P00533-1, 25-1210, Thr-263, CHEBI:50342|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1996336 "PR:000064048 located_in GO:0005886"
is_a: PR:P00533 ! epidermal growth factor receptor (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens