[Term]
id: PR:000064775
name: mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated and ubiquitinated 1 (human)
def: "A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed, that has been phosphorylated on the residues at the positions equivalent to Thr-220, Ser-465, and Ser-467 of the amino acid sequence represented by UniProtKB:Q15796-1, and that includes at least 1 ubiquitinated lysine. Example: UniProtKB:Q15796-1, 2-467, Thr-220, MOD:00047|Ser-465/Ser-467, MOD:00046|MOD:01148." [PRO:DNx, Reactome:R-HSA-9773843]
comment: Category=organism-modification.
synonym: "hSMAD2/InitMet-/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "Ub,p-T220,S465,S467-SMAD2" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-9773843]
synonym: "UniProtKB:Q15796, 2-467, Thr-220, MOD:00047|Ser-465/Ser-467, MOD:00046|MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:Q15796-1, 2-467, Thr-220, MOD:00047|Ser-465/Ser-467, MOD:00046|MOD:01148" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-9773843 "PR:000064775 located_in GO:0005654"
is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens