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Protein Ontology report - BMP receptor-regulated SMAD family member protein
PR:000000038 - http://purl.obolibrary.org/obo/PR_000000038
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000038   
  PRO nameBMP receptor-regulated SMAD family member protein 
  Synonyms
PRO-Short-label: EXACT:R-SMAD(BMP)
  Definition"A SMAD family member protein that mediates signal transduction through activation of bone morphogenetic protein (BMP) or anti-Mullerian hormone pathways." [PMID:11532220] 
  PRO Categoryfamily 
  ParentPR:000000027 SMAD family member protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 10                                        
         Sequence5                                                  Organism-Sequence 10                                        
         Modification13                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500500
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000038 BMP receptor-regulated SMAD family member protein
R-SMAD(BMP)
Yes
gene


PR:000000363 SMAD family member 1
SMAD1

organism-gene


PR:P70340 SMAD family member 1 (mouse)
mSMAD1

organism-sequence


PR:P70340-1 SMAD family member 1 isoform 1 (mouse)
mSMAD1/iso:1
Yes
organism-modification


PR:000026724 SMAD family member 1 isoform 1 phosphorylated 1 (mouse)
mSMAD1/iso:1/Phos:1
Yes
organism-gene


PR:P97588 SMAD family member 1 (rat)
rSMAD1

organism-gene


PR:Q15797 SMAD family member 1 (human)
hSMAD1

organism-sequence


PR:Q15797-1 SMAD family member 1 isoform 1 (human)
hSMAD1/iso:1
Yes
organism-modification


PR:000026334 SMAD family member 1 isoform 1 phosphorylated 1 (human)
hSMAD1/iso:1/Phos:1
Yes
organism-modification


PR:000036553 SMAD family member 1 isoform 1 phosphorylated and ubiquitinated 1 (human)
hSMAD1/iso:1/PhosUbiq:1
Yes
organism-sequence


PR:Q15797-2 SMAD family member 1 isoform h2 (human)
hSMAD1/iso:h2

organism-modification


PR:000049280 SMAD family member 1 ubiquitinated form (human)
hSMAD1/UbiqLys+

organism-modification


PR:000036553 SMAD family member 1 isoform 1 phosphorylated and ubiquitinated 1 (human)
hSMAD1/iso:1/PhosUbiq:1
Yes
organism-modification


PR:000050147 SMAD family member 1 phosphorylated 1 (human)
hSMAD1/Phos:1

sequence


PR:000000467 SMAD family member 1 isoform 1
SMAD1/iso:1

organism-sequence


PR:P70340-1 SMAD family member 1 isoform 1 (mouse)
mSMAD1/iso:1
Yes
organism-modification


PR:000026724 SMAD family member 1 isoform 1 phosphorylated 1 (mouse)
mSMAD1/iso:1/Phos:1
Yes
organism-sequence


PR:Q15797-1 SMAD family member 1 isoform 1 (human)
hSMAD1/iso:1
Yes
organism-modification


PR:000026334 SMAD family member 1 isoform 1 phosphorylated 1 (human)
hSMAD1/iso:1/Phos:1
Yes
organism-modification


PR:000036553 SMAD family member 1 isoform 1 phosphorylated and ubiquitinated 1 (human)
hSMAD1/iso:1/PhosUbiq:1
Yes
modification


PR:000000570 SMAD family member 1 isoform 1 phosphorylated and ubiquitinated form
SMAD1/iso:1/PhosUbiq+

modification


PR:000000648 SMAD family member 1 isoform 1 phosphorylated and ubiquitinated 1
SMAD1/iso:1/PhosUbiq:1

organism-modification


PR:000036553 SMAD family member 1 isoform 1 phosphorylated and ubiquitinated 1 (human)
hSMAD1/iso:1/PhosUbiq:1
Yes
modification


PR:000000571 SMAD family member 1 isoform 1 phosphorylated form
SMAD1/iso:1/PhosRes+

modification


PR:000000570 SMAD family member 1 isoform 1 phosphorylated and ubiquitinated form
SMAD1/iso:1/PhosUbiq+

modification


PR:000000648 SMAD family member 1 isoform 1 phosphorylated and ubiquitinated 1
SMAD1/iso:1/PhosUbiq:1

organism-modification


PR:000036553 SMAD family member 1 isoform 1 phosphorylated and ubiquitinated 1 (human)
hSMAD1/iso:1/PhosUbiq:1
Yes
modification


PR:000000647 SMAD family member 1 isoform 1 phosphorylated 1
SMAD1/iso:1/Phos:1
Yes
organism-modification


PR:000026334 SMAD family member 1 isoform 1 phosphorylated 1 (human)
hSMAD1/iso:1/Phos:1
Yes
organism-modification


PR:000026724 SMAD family member 1 isoform 1 phosphorylated 1 (mouse)
mSMAD1/iso:1/Phos:1
Yes
modification


PR:000050148 SMAD family member 1 phosphorylated 1
SMAD1/Phos:1

organism-modification


PR:000050147 SMAD family member 1 phosphorylated 1 (human)
hSMAD1/Phos:1

gene


PR:000000372 SMAD family member 5
SMAD5

organism-gene


PR:P97454 SMAD family member 5 (mouse)
mSMAD5

organism-sequence


PR:P97454-1 SMAD family member 5 isoform 1 (mouse)
mSMAD5/iso:1
Yes
organism-modification


PR:000036563 SMAD family member 5 isoform 1 phosphorylated 1 (mouse)
mSMAD5/iso:1/Phos:1
Yes
organism-gene


PR:Q56I99 SMAD family member 5 (chicken)
chick-SMAD5

organism-gene


PR:Q99717 SMAD family member 5 (human)
hSMAD5

organism-sequence


PR:000029962 SMAD family member 5 isoform 2 (human)
hSMAD5/iso:2
Yes
organism-sequence


PR:Q99717-1 SMAD family member 5 isoform 1 (human)
hSMAD5/iso:1
Yes
organism-modification


PR:000036562 SMAD family member 5 isoform 1 phosphorylated 1 (human)
hSMAD5/iso:1/Phos:1
Yes
organism-modification


PR:000049289 SMAD family member 5, initiator methionine removed form (human)
hSMAD5/InitMet-

organism-modification


PR:000049290 SMAD family member 5, initiator methionine removed phosphorylated 1 (human)
hSMAD5/InitMet-/Phos:1

organism-gene


PR:Q9R1V3 SMAD family member 5 (rat)
rSMAD5

sequence


PR:000000477 SMAD family member 5 isoform 1
SMAD5/iso:1

organism-sequence


PR:P97454-1 SMAD family member 5 isoform 1 (mouse)
mSMAD5/iso:1
Yes
organism-modification


PR:000036563 SMAD family member 5 isoform 1 phosphorylated 1 (mouse)
mSMAD5/iso:1/Phos:1
Yes
organism-sequence


PR:Q99717-1 SMAD family member 5 isoform 1 (human)
hSMAD5/iso:1
Yes
organism-modification


PR:000036562 SMAD family member 5 isoform 1 phosphorylated 1 (human)
hSMAD5/iso:1/Phos:1
Yes
modification


PR:000000580 SMAD family member 5 isoform 1 phosphorylated form
SMAD5/iso:1/PhosRes+

modification


PR:000000661 SMAD family member 5 isoform 1 phosphorylated 1
SMAD5/iso:1/Phos:1

organism-modification


PR:000036562 SMAD family member 5 isoform 1 phosphorylated 1 (human)
hSMAD5/iso:1/Phos:1
Yes
organism-modification


PR:000036563 SMAD family member 5 isoform 1 phosphorylated 1 (mouse)
mSMAD5/iso:1/Phos:1
Yes
modification


PR:000026652 SMAD family member 5 isoform 1, initiator methionine removed form
SMAD5/iso:1/InitMet-

sequence


PR:000000478 SMAD family member 5 isoform 2
SMAD5/iso:2

organism-sequence


PR:000029962 SMAD family member 5 isoform 2 (human)
hSMAD5/iso:2
Yes
modification


PR:000018297 SMAD family member 5, initiator methionine removed form
SMAD5/InitMet-

modification


PR:000026652 SMAD family member 5 isoform 1, initiator methionine removed form
SMAD5/iso:1/InitMet-

organism-modification


PR:000049289 SMAD family member 5, initiator methionine removed form (human)
hSMAD5/InitMet-

organism-modification


PR:000049290 SMAD family member 5, initiator methionine removed phosphorylated 1 (human)
hSMAD5/InitMet-/Phos:1

gene


PR:000000375 SMAD family member 9
SMAD9

organism-gene


PR:O15198 SMAD family member 9 (human)
hSMAD9

organism-sequence


PR:000029959 SMAD family member 9 isoform 3 (human)
hSMAD9/iso:3
Yes
organism-sequence


PR:O15198-1 SMAD family member 9 isoform A (human)
hSMAD9/iso:A

organism-modification


PR:000028350 SMAD family member 9 isoform 3 phosphorylated 1 (human)
hSMAD9/iso:3/Phos:1

organism-sequence


PR:O15198-2 SMAD family member 9 isoform B (human)
hSMAD9/iso:B

organism-modification


PR:000049291 SMAD family member 9 phosphorylated 1 (human)
hSMAD9/Phos:1

organism-modification


PR:000067869 SMAD family member 9 methylated 1 (human)
hSMAD9/Me:1

organism-modification


PR:000085152 SMAD family member 9 methylated 2 (human)
hSMAD9/Me:2

organism-gene


PR:O54835 SMAD family member 9 (rat)
rSMAD9

organism-gene


PR:Q9JIW5 SMAD family member 9 (mouse)
mSMAD9

organism-sequence


PR:Q9JIW5-1 SMAD family member 9 isoform 1 (mouse)
mSMAD9/iso:1
Yes
organism-modification


PR:000036567 SMAD family member 9 isoform 1 phosphorylated 1 (mouse)
mSMAD9/iso:1/Phos:1
Yes
sequence


PR:000000482 SMAD family member 9 isoform 1
SMAD9/iso:1

organism-sequence


PR:O15198-2 SMAD family member 9 isoform B (human)
hSMAD9/iso:B

organism-sequence


PR:Q9JIW5-1 SMAD family member 9 isoform 1 (mouse)
mSMAD9/iso:1
Yes
organism-modification


PR:000036567 SMAD family member 9 isoform 1 phosphorylated 1 (mouse)
mSMAD9/iso:1/Phos:1
Yes
modification


PR:000000585 SMAD family member 9 isoform 1 phosphorylated form
SMAD9/iso:1/PhosRes+

modification


PR:000000666 SMAD family member 9 isoform 1 phosphorylated 1
SMAD9/iso:1/Phos:1

organism-modification


PR:000036567 SMAD family member 9 isoform 1 phosphorylated 1 (mouse)
mSMAD9/iso:1/Phos:1
Yes
sequence


PR:000000484 SMAD family member 9 isoform 3
SMAD9/iso:3

organism-sequence


PR:O15198-1 SMAD family member 9 isoform A (human)
hSMAD9/iso:A

organism-modification


PR:000028350 SMAD family member 9 isoform 3 phosphorylated 1 (human)
hSMAD9/iso:3/Phos:1

modification


PR:000000586 SMAD family member 9 isoform 3 phosphorylated form
SMAD9/iso:3/PhosRes+

modification


PR:000000667 SMAD family member 9 isoform 3 phosphorylated 1
SMAD9/iso:3/Phos:1

organism-modification


PR:000028350 SMAD family member 9 isoform 3 phosphorylated 1 (human)
hSMAD9/iso:3/Phos:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000038 R-SMAD(BMP) acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PANTHER:PTHR13703; PIRSF:PIRSF500500
PR:000000647 SMAD1/iso:1/Phos:1
Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046		 enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10708949
PR:000026334 hSMAD1/iso:1/Phos:1
UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:9759503
GO:0030509 BMP signaling pathway PMID:8653785
enablesGO:0046332 SMAD binding with PR:Q13485 deletion target in pancreatic carcinoma 4 (human) PMID:9136927
located_inGO:0005634 nucleus PMID:11509558; PMID:9759503
PR:000026724 mSMAD1/iso:1/Phos:1
UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046		 acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation PMID:15899870
GO:0030509 BMP signaling pathway PMID:12370310; PMID:15198985
enablesGO:0005515 protein binding with PR:Q04211 BTG family member 2 (mouse) PMID:14633973
GO:0005515 protein binding with PR:Q8BGV5 mZNF8 PMID:14633973
GO:0005515 protein binding with PR:Q9QZH6 Ecsit PMID:14633973
located_inGO:0005634 nucleus PMID:10504300; PMID:12151307; PMID:12370310
GO:0005667 transcription factor complex PMID:14633973
GO:0005769 early endosome PMID:17592637
PR:000029959 hSMAD9/iso:3 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:10583507
enablesGO:0046332 SMAD binding PMID:10583507
located_inGO:0005737 cytoplasm PMID:10583507
PR:000029962 hSMAD5/iso:2 enablesNOT GO:0046332 SMAD binding PMID:10845932
PR:000036553 hSMAD1/iso:1/PhosUbiq:1
UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148		 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:12857866
PR:000036562 hSMAD5/iso:1/Phos:1
UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046		 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:8637600
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8673135
PR:000036563 mSMAD5/iso:1/Phos:1
UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046		 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:16522160
located_inGO:0005634 nucleus PMID:10504300; PMID:9759503
PR:000036567 mSMAD9/iso:1/Phos:1
UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046		 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:11163184; PMID:15542835
enablesGO:0005515 protein binding PMID:11163184; PMID:15542835
located_inGO:0005634 nucleus PMID:10814522
PR:P70340-1 mSMAD1/iso:1 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:15198985; PMID:15331632; PMID:17356069
located_inGO:0005737 cytoplasm PMID:10504300; PMID:17356069
PR:P97454-1 mSMAD5/iso:1 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:16765933
GO:0030509 BMP signaling pathway PMID:16522160; PMID:16765933
located_inGO:0005737 cytoplasm PMID:10504300
PR:Q15797-1 hSMAD1/iso:1 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:8637600
GO:0030509 BMP signaling pathway PMID:8653785
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10708949
GO:0005102 signaling receptor binding PMID:9136927; PMID:9748228
GO:0005515 protein binding PMID:17356069
located_inGO:0005737 cytoplasm PMID:11509558
PR:Q99717-1 hSMAD5/iso:1 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:8673135
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8673135
PR:Q9JIW5-1 mSMAD9/iso:1 acts_upstream_of_or_withinGO:0048856 anatomical structure development PMID:15899870
located_inGO:0005622 intracellular anatomical structure PMID:10814522