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Protein Ontology report - SMAD family member 3
PR:000000365 - http://purl.obolibrary.org/obo/PR_000000365
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000365   
  PRO nameSMAD family member 3 
  Synonyms
PRO-Short-label: EXACT:SMAD3
Gene-based: RELATED:MADH3
Other: EXACT:JV15-2 | MAD homolog 3 | MAD-3 | mad3 | mothers against decapentaplegic homolog 3 | mothers against DPP homolog 3 | SMAD 3
  Definition"A TGF-beta receptor-regulated SMAD family member protein that is a translation product of the human SMAD3 gene or a 1:1 ortholog thereof." [PMID:9311995] 
  PRO Categorygene 
  ParentPR:000000066 TGF-beta receptor-regulated SMAD family member protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 7                                        
         Modification6                                                  Organism-Modification 18                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000365 SMAD family member 3
SMAD3

organism-gene


PR:P84022 SMAD family member 3 (human)
hSMAD3

organism-sequence


PR:000062539 SMAD family member 3 sequence variant S425F (human)
hSMAD3/var:S425F

organism-sequence


PR:000063486 SMAD family member 3 sequence variant S425C (human)
hSMAD3/var:S425C

organism-sequence


PR:P84022-1 SMAD family member 3 isoform 1 (human)
hSMAD3/iso:1
Yes
organism-modification


PR:000026333 SMAD family member 3 isoform 1 phosphorylated 1 (human)
hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036557 SMAD family member 3 isoform 1 acetylated and phosphorylated 1 (human)
hSMAD3/iso:1/AcPhos:1
Yes
organism-sequence


PR:P84022-2 SMAD family member 3 isoform h2 (human)
hSMAD3/iso:h2

organism-sequence


PR:P84022-3 SMAD family member 3 isoform h3 (human)
hSMAD3/iso:h3

organism-sequence


PR:P84022-4 SMAD family member 3 isoform h4 (human)
hSMAD3/iso:h4

organism-modification


PR:000049285 SMAD family member 3 phosphorylated 1 (human)
hSMAD3/Phos:1

organism-modification


PR:000049286 SMAD family member 3 phosphorylated 2 (human)
hSMAD3/Phos:2

organism-modification


PR:000049287 SMAD family member 3 ubiquitinated form (human)
hSMAD3/UbiqLys+

organism-modification


PR:000064859 SMAD family member 3 phosphorylated and ubiquitinated 1 (human)
hSMAD3/PhosUbiq:1

organism-modification


PR:000060563 SMAD family member 3 sequence variant R268H phosphorylated 1 (human)
hSMAD3/var:R268H/Phos:1

organism-modification


PR:000061858 SMAD family member 3 ADP-ribosylated and phosphorylated 1 (human)
hSMAD3/ADPribPhos:1

organism-modification


PR:000063368 SMAD family member 3 phosphorylated 3 (human)
hSMAD3/Phos:3

organism-modification


PR:000063580 SMAD family member 3 sequence variant R268C phosphorylated 1 (human)
hSMAD3/var:R268C/Phos:1

organism-modification


PR:000063639 SMAD family member 3 sequence variant D258N phosphorylated 1 (human)
hSMAD3/var:D258N/Phos:1

organism-modification


PR:000065228 SMAD family member 3 deaminated 1 (human)
hSMAD3/Deam:1

organism-modification


PR:000065534 SMAD family member 3 methylated 1 (human)
hSMAD3/Me:1

organism-modification


PR:000073148 SMAD family member 3 cysteinylated 1 (human)
hSMAD3/Cyst:1

organism-modification


PR:000074741 SMAD family member 3 methylated 2 (human)
hSMAD3/Me:2

organism-gene


PR:P84023 SMAD family member 3 (chicken)
chick-SMAD3

organism-gene


PR:P84025 SMAD family member 3 (rat)
rSMAD3

organism-gene


PR:Q8BUN5 SMAD family member 3 (mouse)
mSMAD3

organism-sequence


PR:Q8BUN5-1 SMAD family member 3 isoform 1 (mouse)
mSMAD3/iso:1
Yes
organism-modification


PR:000036558 SMAD family member 3 isoform 1 phosphorylated 1 (mouse)
mSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036560 SMAD family member 3 isoform 1 phosphorylated 2 (mouse)
mSMAD3/iso:1/Phos:2
Yes
organism-modification


PR:000036561 SMAD family member 3 isoform 1 phosphorylated 3 (mouse)
mSMAD3/iso:1/Phos:3
Yes
sequence


PR:000000475 SMAD family member 3 isoform 1
SMAD3/iso:1

organism-sequence


PR:P84022-1 SMAD family member 3 isoform 1 (human)
hSMAD3/iso:1
Yes
organism-modification


PR:000026333 SMAD family member 3 isoform 1 phosphorylated 1 (human)
hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036557 SMAD family member 3 isoform 1 acetylated and phosphorylated 1 (human)
hSMAD3/iso:1/AcPhos:1
Yes
organism-sequence


PR:Q8BUN5-1 SMAD family member 3 isoform 1 (mouse)
mSMAD3/iso:1
Yes
organism-modification


PR:000036558 SMAD family member 3 isoform 1 phosphorylated 1 (mouse)
mSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036560 SMAD family member 3 isoform 1 phosphorylated 2 (mouse)
mSMAD3/iso:1/Phos:2
Yes
organism-modification


PR:000036561 SMAD family member 3 isoform 1 phosphorylated 3 (mouse)
mSMAD3/iso:1/Phos:3
Yes
modification


PR:000000577 SMAD family member 3 isoform 1 acetylated and phosphorylated form
SMAD3/iso:1/AcPhos+

modification


PR:000000657 SMAD family member 3 isoform 1 acetylated and phosphorylated 1
SMAD3/iso:1/AcPhos:1

organism-modification


PR:000036557 SMAD family member 3 isoform 1 acetylated and phosphorylated 1 (human)
hSMAD3/iso:1/AcPhos:1
Yes
modification


PR:000000578 SMAD family member 3 isoform 1 phosphorylated form
SMAD3/iso:1/PhosRes+

modification


PR:000000577 SMAD family member 3 isoform 1 acetylated and phosphorylated form
SMAD3/iso:1/AcPhos+

modification


PR:000000657 SMAD family member 3 isoform 1 acetylated and phosphorylated 1
SMAD3/iso:1/AcPhos:1

organism-modification


PR:000036557 SMAD family member 3 isoform 1 acetylated and phosphorylated 1 (human)
hSMAD3/iso:1/AcPhos:1
Yes
modification


PR:000000658 SMAD family member 3 isoform 1 phosphorylated 1
SMAD3/iso:1/Phos:1

organism-modification


PR:000026333 SMAD family member 3 isoform 1 phosphorylated 1 (human)
hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036558 SMAD family member 3 isoform 1 phosphorylated 1 (mouse)
mSMAD3/iso:1/Phos:1
Yes
modification


PR:000000659 SMAD family member 3 isoform 1 phosphorylated 2
SMAD3/iso:1/Phos:2

organism-modification


PR:000036560 SMAD family member 3 isoform 1 phosphorylated 2 (mouse)
mSMAD3/iso:1/Phos:2
Yes
modification


PR:000000660 SMAD family member 3 isoform 1 phosphorylated 3
SMAD3/iso:1/Phos:3

organism-modification


PR:000036561 SMAD family member 3 isoform 1 phosphorylated 3 (mouse)
mSMAD3/iso:1/Phos:3
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026333 hSMAD3/iso:1/Phos:1
UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046		 acts_upstream_of_or_withinGO:0006366 transcription by RNA polymerase II PMID:10823886
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881; PMID:9380693
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10823886; PMID:12943993
GO:0008134 transcription factor binding PMID:15084259
GO:0046332 SMAD binding PMID:15350224; PMID:9311995
located_inGO:0005634 nucleus PMID:10846168; PMID:15280432
GO:0005667 transcription factor complex PMID:12374795
PR:000036557 hSMAD3/iso:1/AcPhos:1
UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756
enablesGO:0003700 DNA-binding transcription factor activity PMID:17074756
located_inGO:0005634 nucleus PMID:17074756
PR:000036558 mSMAD3/iso:1/Phos:1
UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046		 enablesGO:0003690 double-stranded DNA binding PMID:15282343
GO:0003700 DNA-binding transcription factor activity PMID:10823886; PMID:12943993
GO:0008134 transcription factor binding PMID:15464984; PMID:9702197
located_inGO:0005634 nucleus PMID:12943993; PMID:15282343
GO:0005667 transcription factor complex PMID:9702197
PR:000036560 mSMAD3/iso:1/Phos:2
UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046		 enablesdecreased GO:0003700 DNA-binding transcription factor activity relative to PR:000036558 mSMAD3/iso:1/Phos:1 PMID:15241418
PR:000036561 mSMAD3/iso:1/Phos:3
UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046		 enablesNOT GO:0003713 transcription coactivator activity PMID:10197981
located_inGO:0005737 cytoplasm PMID:10197981
PR:P84022-1 hSMAD3/iso:1 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881
enablesGO:0005515 protein binding with PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125
GO:0005515 protein binding with PR:O95405-1 PMID:12154125
located_inGO:0005737 cytoplasm PMID:17074053
PR:Q8BUN5-1 mSMAD3/iso:1 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12543979
enablesGO:0005515 protein binding with PR:000036434 mTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125
GO:0005515 protein binding with PR:A2A8R0 mZFYVE9/iso:1 PMID:12154125