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Protein Ontology report - SMAD family member 2 isoform Long
PR:000000468 - http://purl.obolibrary.org/obo/PR_000000468
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000468   
  PRO nameSMAD family member 2 isoform Long 
  Synonyms
PRO-Short-label: EXACT:SMAD2/iso:Long
Other: EXACT:mothers against decapentaplegic homolog 2 isoform 1 | smad2 isoform 1
  Definition"A SMAD family member 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15796-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000364 SMAD family member 2
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification11                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000000468 SMAD family member 2 isoform Long
SMAD2/iso:Long

organism-sequence


PR:Q15796-1 SMAD family member 2 isoform Long (human)
hSMAD2/iso:Long

organism-modification


PR:000025934 SMAD family member 2 isoform Long phosphorylated 1 (human)
hSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000025935 SMAD family member 2 isoform Long phosphorylated 2 (human)
hSMAD2/iso:Long/Phos:2
Yes
Yes
organism-modification


PR:000025936 SMAD family member 2 isoform Long phosphorylated 3 (human)
hSMAD2/iso:Long/Phos:3
Yes
Yes
organism-modification


PR:000025937 SMAD family member 2 isoform Long phosphorylated 4 (human)
hSMAD2/iso:Long/Phos:4
Yes
organism-modification


PR:000036554 SMAD family member 2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
Yes
organism-modification


PR:000045371 SMAD family member 2 isoform Long unphosphorylated 1 (human)
hSMAD2/iso:Long/UnPhos:1
Yes
Yes
organism-sequence


PR:Q62432-1 SMAD family member 2 isoform Long (mouse)
mSMAD2/iso:Long
Yes
organism-modification


PR:000025942 SMAD family member 2 isoform Long phosphorylated 1 (mouse)
mSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000036482 SMAD family member 2 isoform Long phosphorylated and ubiquitinated form (mouse)
mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 SMAD family member 2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
modification


PR:000000572 SMAD family member 2 isoform Long acetylated and phosphorylated form
SMAD2/iso:Long/AcPhos+

modification


PR:000000649 SMAD family member 2 isoform Long acetylated and phosphorylated 1
SMAD2/iso:Long/AcPhos:1

organism-modification


PR:000036554 SMAD family member 2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
Yes
modification


PR:000000573 SMAD family member 2 isoform Long phosphorylated and ubiquitinated form
SMAD2/iso:Long/PhosUbiq+

modification


PR:000000654 SMAD family member 2 isoform Long phosphorylated and ubiquitinated 1
SMAD2/iso:Long/PhosUbiq:1

organism-modification


PR:000036555 SMAD family member 2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
organism-modification


PR:000036482 SMAD family member 2 isoform Long phosphorylated and ubiquitinated form (mouse)
mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 SMAD family member 2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
modification


PR:000000574 SMAD family member 2 isoform Long phosphorylated form
SMAD2/iso:Long/PhosRes+

modification


PR:000000572 SMAD family member 2 isoform Long acetylated and phosphorylated form
SMAD2/iso:Long/AcPhos+

modification


PR:000000649 SMAD family member 2 isoform Long acetylated and phosphorylated 1
SMAD2/iso:Long/AcPhos:1

organism-modification


PR:000036554 SMAD family member 2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
Yes
modification


PR:000000573 SMAD family member 2 isoform Long phosphorylated and ubiquitinated form
SMAD2/iso:Long/PhosUbiq+

modification


PR:000000654 SMAD family member 2 isoform Long phosphorylated and ubiquitinated 1
SMAD2/iso:Long/PhosUbiq:1

organism-modification


PR:000036555 SMAD family member 2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
organism-modification


PR:000036482 SMAD family member 2 isoform Long phosphorylated and ubiquitinated form (mouse)
mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 SMAD family member 2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
Yes
modification


PR:000000650 SMAD family member 2 isoform Long phosphorylated 1
SMAD2/iso:Long/Phos:1

Yes
organism-modification


PR:000025934 SMAD family member 2 isoform Long phosphorylated 1 (human)
hSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000025942 SMAD family member 2 isoform Long phosphorylated 1 (mouse)
mSMAD2/iso:Long/Phos:1
Yes
Yes
modification


PR:000000651 SMAD family member 2 isoform Long phosphorylated 2
SMAD2/iso:Long/Phos:2

Yes
organism-modification


PR:000025935 SMAD family member 2 isoform Long phosphorylated 2 (human)
hSMAD2/iso:Long/Phos:2
Yes
Yes
modification


PR:000000652 SMAD family member 2 isoform Long phosphorylated 3
SMAD2/iso:Long/Phos:3

Yes
organism-modification


PR:000025936 SMAD family member 2 isoform Long phosphorylated 3 (human)
hSMAD2/iso:Long/Phos:3
Yes
Yes
modification


PR:000000653 SMAD family member 2 isoform Long phosphorylated 4
SMAD2/iso:Long/Phos:4

organism-modification


PR:000025937 SMAD family member 2 isoform Long phosphorylated 4 (human)
hSMAD2/iso:Long/Phos:4
Yes
modification


PR:000002570 SMAD family member 2 isoform Long unmodified form
SMAD2/iso:Long/UnMod

Yes
modification


PR:000026718 SMAD family member 2 isoform Long, initiator methionine removed form
SMAD2/iso:Long/InitMet-

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SMAD2/iso:Long forms found in complexes   

SMAD2/iso:Long Component
 Complexes
PR:000000650 SMAD2/iso:Long/Phos:1 PR:000025967 smad2-smad4 protein complex 1
PR:000025971 smad2-smad4-ski protein complex 1
PR:000000651 SMAD2/iso:Long/Phos:2 PR:000025969 smad2-smad4 protein complex 3
PR:000000652 SMAD2/iso:Long/Phos:3 PR:000025970 smad2-smad4 protein complex 4
PR:000002570 SMAD2/iso:Long/UnMod PR:000025972 smad2-smad4-ski protein complex 2
PR:000025934 hSMAD2/iso:Long/Phos:1 PR:000025933 smad2-smad4 protein complex 1 (human)
PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:000025935 hSMAD2/iso:Long/Phos:2 PR:000025946 smad2-smad4 protein complex 3 (human)
PR:000025936 hSMAD2/iso:Long/Phos:3 PR:000025947 smad2-smad4 protein complex 4 (human)
PR:000025942 mSMAD2/iso:Long/Phos:1 PR:000025944 smad2-smad4 protein complex 1 (mouse)
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PR:000025952 smad2-smad4-ski protein complex 2 (human)
PR:000025965 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025934 hSMAD2/iso:Long/Phos:1
UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:15690394; PMID:9689110
GO:0007165 signal transduction PMID:8752209; PMID:8980228; PMID:9346966
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209; PMID:8980228
GO:0060395 SMAD protein signal transduction PMID:9346966
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8980228; PMID:9346966
GO:0003713 transcription coactivator activity PMID:9689110
GO:0046332 SMAD binding PMID:9311995
located_inGO:0005634 nucleus PMID:9006934; PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2
Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:12193595
GO:0007165 signal transduction PMID:12193595
GO:0060395 SMAD protein signal transduction PMID:12193595
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:12193595
GO:0003712 transcription coregulator activity PMID:12193595
GO:0046332 SMAD binding PMID:12193595
located_inGO:0005634 nucleus PMID:12193595; PMID:17074053
PR:000025936 hSMAD2/iso:Long/Phos:3
UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:11027280
GO:0060395 SMAD protein signal transduction PMID:11027280
enablesNOT GO:0003713 transcription coactivator activity PMID:11027280
GO:0046332 SMAD binding PMID:11027280
located_inGO:0005737 cytoplasm PMID:11027280
PR:000025937 hSMAD2/iso:Long/Phos:4
UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046		 enablesNOT GO:0003713 transcription coactivator activity PMID:10197981
located_inGO:0005737 cytoplasm PMID:10197981
PR:000025942 mSMAD2/iso:Long/Phos:1
UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:11262418
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11262418
enablesGO:0003713 transcription coactivator activity PMID:15282343
GO:0046332 SMAD binding PMID:11043574
located_inGO:0005634 nucleus PMID:11557747
PR:000036554 hSMAD2/iso:Long/AcPhos:1
UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:17074756
GO:0007165 signal transduction PMID:17074756
located_inGO:0005634 nucleus PMID:17074756
PR:000036555 mSMAD2/iso:Long/PhosUbiq:1
UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:15496141
enablesNOT GO:0003713 transcription coactivator activity PMID:15496141
PR:000045371 hSMAD2/iso:Long/UnPhos:1
UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209
enablesGO:0005515 protein binding PMID:8980228
located_inGO:0005737 cytoplasm PMID:15280432; PMID:17074053
GO:0005769 early endosome PMID:12356868
PR:Q62432-1 mSMAD2/iso:Long acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11557747
located_inGO:0005737 cytoplasm PMID:14701940