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Protein Ontology report - SMAD family member 7 isoform 1

PR:000000481 - http://purl.obolibrary.org/obo/PR_000000481

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000000481

PRO name

SMAD family member 7 isoform 1

Synonyms

PRO-Short-label:

EXACT:

SMAD7/iso:1

Definition

"A SMAD family member 7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35253-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

PRO Category

sequence

Parent

PR:000000374 SMAD family member 7

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Sequence	1	Organism-Sequence	2
Modification	6	Organism-Modification	5

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

sequence

PR:000000481 SMAD family member 7 isoform 1

SMAD7/iso:1

organism-sequence

PR:O15105-1 SMAD family member 7 isoform 1 (human)

hSMAD7/iso:1

Yes

organism-modification

PR:000036565 SMAD family member 7 isoform 1 acetylated 1 (human)

hSMAD7/iso:1/Ac:1

Yes

organism-modification

PR:000036566 SMAD family member 7 isoform 1 phosphorylated 1 (human)

hSMAD7/iso:1/Phos:1

organism-sequence

PR:O35253-1 SMAD family member 7 isoform A (mouse)

mSMAD7/iso:A

organism-modification

PR:000036932 SMAD family member 7 isoform 1 phosphorylated 1 (mouse)

mSMAD7/iso:1/Phos:1

Yes

organism-modification

PR:000049801 SMAD family member 7 isoform A monomethylated 1 (mouse)

mSMAD7/iso:A/Me1:1

organism-modification

PR:000049802 SMAD family member 7 isoform A unmethylated 1 (mouse)

mSMAD7/iso:A/UnMe:1

modification

PR:000000582 SMAD family member 7 isoform 1 acetylated form

SMAD7/iso:1/AcRes+

modification

PR:000000663 SMAD family member 7 isoform 1 acetylated 1

SMAD7/iso:1/Ac:1

organism-modification

PR:000036565 SMAD family member 7 isoform 1 acetylated 1 (human)

hSMAD7/iso:1/Ac:1

Yes

modification

PR:000000583 SMAD family member 7 isoform 1 phosphorylated form

SMAD7/iso:1/PhosRes+

modification

PR:000000664 SMAD family member 7 isoform 1 phosphorylated 1

SMAD7/iso:1/Phos:1

organism-modification

PR:000036566 SMAD family member 7 isoform 1 phosphorylated 1 (human)

hSMAD7/iso:1/Phos:1

organism-modification

PR:000036932 SMAD family member 7 isoform 1 phosphorylated 1 (mouse)

mSMAD7/iso:1/Phos:1

Yes

modification

PR:000000584 SMAD family member 7 isoform 1 ubiquitinated form

SMAD7/iso:1/UbiqLys+

modification

PR:000000665 SMAD family member 7 isoform 1 ubiquitinated 1

SMAD7/iso:1/Ubiq:1

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000036565 hSMAD7/iso:1/Ac:1 UniProtKB:O15105-1, Lys-64/Lys-70, MOD:00064	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:12408818
	enables	GO:0140416 transcription regulator inhibitor activity	PMID:12408818
	located_in	GO:0005634 nucleus	PMID:11278814
PR:000036932 mSMAD7/iso:1/Phos:1 UniProtKB:O35253-1, Ser-249, MOD:00046	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:11278814
	enables	GO:0140416 transcription regulator inhibitor activity	PMID:11278814
	located_in	GO:0005634 nucleus	PMID:11278814
PR:O15105-1 hSMAD7/iso:1	acts_upstream_of_or_within	GO:0006950 response to stress	PMID:9256479
	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:10823886; PMID:9215638
	enables	GO:0005515 protein binding	PMID:9256479
	enables	GO:0140416 transcription regulator inhibitor activity	PMID:9215638
	located_in	GO:0005634 nucleus	PMID:11278814