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   PRO ID
PRO Name
PRO Term Definition
Category
Parent
GO:0071144
heteromeric SMAD protein complexA protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric. [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020] GO:0005667; G0071141
PR:000000099
inhibitory smad proteinA smad protein that is an antagonist of the transforming growth factor beta (TGF-beta) superfamily signaling pathways. It lacks the C-terminal SSxS motif, necessary for receptor mediated phosphorylation that is present in the receptor-regulated smads. [PMID:11532220]familyPR:000000027
PR:000000027
smad proteinA protein with core domain composition consisting of one MH1 domain (Pfam:PF03165) at the N terminus and one MH2 domain (Pfam:PF03166) at the C-terminus, separated by a non-conserved linker region. Smad proteins are mediators of signal transduction in transforming growth factor beta (TGF-beta) superfamily pathways. [PRO:CNA]familyPR:000000001
PR:000000127
smad ubiquitination regulatory factorA HECT domain-containing E3 ubiquitin-protein ligase with WW domains that mediates smad ubiquitination. [PRO:CNA]familyPR:000000016
GO:0071141
SMAD protein complexA protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven. [GOC:bhm, GOC:mah, PMID:9670020] GO:0032991
PR:000000038
BMP receptor-regulated smad proteinA smad protein that mediates signal transduction through activation of bone morphogenetic protein (BMP) or anti-Mullerian hormone pathways. [PMID:11532220]familyPR:000000027
PR:000027744
TGF-beta receptor-regulated smad protein unmodified formA TGF-beta receptor-regulated smad protein that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage. [PRO:CNA]modificationPR:000000066
PR:000027745
TGF-beta receptor-regulated smad protein unmodified form (human)A TGF-beta receptor-regulated smad protein unmodified form in human. [PRO:CNA]organism-modificationPR:000027744; PR:000029067
PR:Q8BIZ6
smad nuclear-interacting protein 1 (mouse)A smad nuclear-interacting protein 1 that is encoded in the genome of mouse. [OMA:Q8BIZ6, PRO:DNx]organism-genePR:000015328; PR:000029032
PR:Q8TAD8
smad nuclear-interacting protein 1 (human)A smad nuclear-interacting protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TAD8]organism-genePR:000015328; PR:000029067
PR:Q5M9G6
smad nuclear interacting protein 1 (rat)A smad nuclear-interacting protein 1 that is encoded in the genome of rat. [OMA:Q5M9G6, PANTHER:PTHR23308\:SF8, PRO:DNx]organism-genePR:000015328; PR:000029033
PR:000000066
TGF-beta receptor-regulated smad proteinA smad protein that mediates signal transduction through activation of transforming growth factor beta (TGF-beta) or activin pathways. [PMID:11532220]familyPR:000000027
PR:000027747
TGF-beta receptor-regulated smad protein phosphorylated form (human)A TGF-beta receptor-regulated smad protein phosphorylated form in human. [PRO:CNA]organism-modificationPR:000027746; PR:000029067
PR:000027746
TGF-beta receptor-regulated smad protein phosphorylated formA TGF-beta receptor-regulated smad protein that has been phosphorylated in the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation. [PRO:CNA]modificationPR:000000066
PR:000000375
smad9A BMP receptor-regulated smad protein that is a translation product of the human SMAD9 gene or a 1:1 ortholog thereof. [PMID:10708948]genePR:000000038
PR:000000372
smad5A BMP receptor-regulated smad protein that is a translation product of the human SMAD5 gene or a 1:1 ortholog thereof. [PMID:10708949]genePR:000000038
PR:000000128
smad4A smad protein that is a translation product of the human SMAD4 gene or a 1:1 ortholog thereof. It lacks the C-terminal SSxS motif, necessary for receptor mediated phosphorylation, that is present in the receptor-regulated smads. [PMID:10708949, PRO:CNA]genePR:000000027
PR:000000365
smad3A TGF-beta receptor-regulated smad protein that is a translation product of the human SMAD3 gene or a 1:1 ortholog thereof. [PMID:9311995]genePR:000000066
PR:000015328
smad nuclear-interacting protein 1A protein that is a translation product of the human SNIP1 gene or a 1:1 ortholog thereof. [PRO:DNx]genePR:000000001
PR:000000374
smad7An inhibitory smad protein that is a translation product of the human SMAD7 gene or a 1:1 ortholog thereof. Smad7 is a negative regulator of TGF-beta signaling. [PMID:17438144]genePR:000000099
PR:000000478
smad5 isoform 2A smad5 that is a translation product of a mature transcript of the SMAD5 gene comprising intron 6 generating a C-terminus truncated MH2 domain and a unique C-terminus sequence lacking the SSxS motif necessary for SMAD activation. [EST:AA169504, PMID:10845932]sequencePR:000000372
PR:000000363
smad1A BMP receptor-regulated smad protein that is a translation product of the human SMAD1 gene or a 1:1 ortholog thereof. [PMID:10708949, PRO:CNA]genePR:000000038
PR:000000373
smad6An inhibitory smad protein that is a translation product of the human SMAD6 gene or a 1:1 ortholog thereof. Inhibitor of bone morphogenetic protein (BMP) signaling, and the interaction with BMP type 1 receptors is a critical step in the function of smad6. [PMID:17493940]genePR:000000099
PR:000000364
smad2A TGF-beta receptor-regulated smad protein that is a translation product of the human SMAD2 gene or a 1:1 ortholog thereof. [PMID:9311995]genePR:000000066
PR:000000362
E3 ubiquitin-protein ligase SMURF2A smad ubiquitination regulatory factor that is a translation product of the human SMURF2 gene or a 1:1 ortholog thereof. [PRO:CNA]genePR:000000127
PR:000000361
E3 ubiquitin-protein ligase SMURF1A smad ubiquitination regulatory factor that is a translation product of the human SMURF1 gene or a 1:1 ortholog thereof. [PRO:CNA]genePR:000000127
PR:000000026
sara-type zinc finger FYVE domain-containing proteinA protein with a core domain composition consisting of a FYVE zinc finger (Pfam:PF01363) domain and a smad-binding domain that is involved in recruiting and presenting receptor-regulated smads to the receptor complex. [PMID:17356069]familyPR:000000001
PR:Q9W5Q1
CG17168 protein (fruit fly)A smad nuclear-interacting protein 1 that is encoded in the genome of fruit fly. [PANTHER:PTHR23308\:SF8, PRO:DNx]organism-genePR:000015328; PR:000029060
PR:P91125
C32E8.5 protein (worm)A smad nuclear-interacting protein 1 that is encoded in the genome of worm. [PANTHER:PTHR23308\:SF8, PRO:DNx]organism-genePR:000015328; PR:000036194
PR:000000315
sara isoform 3A sara that is a translation product of the mature transcript of ZFYVE9 gene, and lacks the smad-binding domain. Example: UniProtKB:O95405-3. [PRO:CNA]sequencePR:000000125
PR:000000313
sara isoform 1A sara that is a translation product of the longest mature transcript of ZFYVE9 gene, and that contains intact FYVE and smad-binding domains. Example: UniProtKB:O95405-1. [PRO:CNA]sequencePR:000000125
PR:000025970
smad2-smad4 protein complex 4A smad2-smad4 protein complex that contains smad4 and smad2 phosphorylated on a [S/T] residue within the MH1-MH2 domain linker region in response to decorin-induced Ca(2+) signaling. [PMID:11027280]complexGO:0071144
PR:000025969
smad2-smad4 protein complex 3A smad2-smad4 protein complex that contains smad4 and the long isoform of SMAD2 phosphorylated by ERK1. [PMID:12193595]complexGO:0071144
PR:000000480
smad6 isoform 2A smad6 that is a translation product of a mature transcript of the SMAD6 gene, that lacks the MH1 domain. This form is exclusively expressed in coronary tissue and is upregulated in dissease heart tissue. Example: UniProtKB:O43541-2. [PMID:11284962, PRO:CNA]sequencePR:000000373
PR:Q9JIW5
mothers against decapentaplegic homolog 9 (mouse)A smad9 that is encoded in the genome of mouse. [OMA:Q9JIW5, PRO:DNx]organism-genePR:000000375; PR:000029032
PR:O54835
mothers against decapentaplegic homolog 9 (rat)A smad9 that is encoded in the genome of rat. [OMA:O54835, PRO:DNx]organism-genePR:000000375; PR:000029033
PR:000025968
smad2-smad4 protein complex 2A smad2-smad4 protein complex that contains smad4 and the short isoform of smad2 phosphorylated in the last two Ser residues within the SSxS C-terminal motif. [PMID:15350224]complexGO:0071144
PR:000025967
smad2-smad4 protein complex 1A smad2-smad4 protein complex that contains smad4 and the long isoform of smad2 phosphorylated in the last two Ser residues within the SSxS C-terminal motif. [PMID:15350224]complexGO:0071144
PR:000025972
smad2-smad4-ski protein complex 2A smad2-smad4-ski protein complex with unphosphorylated smad2. [PMID:12732634]complexPR:000025950
PR:000000483
smad9 isoform 2A smad9 that is a translation product of a mature transcript of the SMAD9 gene that lacks the last exon, and therefore the C-terminal SSxS motif. Inhibits BMP signaling. [PMID:10583507]sequencePR:000000375
PR:000000482
smad9 isoform 1A smad9 that is a translation product of a mature transcript of the SMAD9 gene that lacks exon 3. Example: UniProtKB:Q9JIW5-1. [PRO:CNA]sequencePR:000000375
PR:000015255
SMAD5 antisense gene protein 1A protein that is a translation product of the human SMAD5-AS1 gene or a 1:1 ortholog thereof. [PRO:DNx]genePR:000000001
PR:000025971
smad2-smad4-ski protein complex 1A smad2-smad4-ski protein complex with phosphorylated smad2. [PRO:CNA]complexPR:000025950
PR:Q9Y6J3
SMAD5 antisense gene protein 1 (human)A SMAD5 antisense gene protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6J3]organism-genePR:000015255; PR:000029067
PR:000025945
smad2-smad4 protein complex 2 (mouse)A smad2-smad4 protein complex 2 in mouse. [PRO:CNA]organism-complexPR:000025968
PR:000025940
smad2-smad4 protein complex 2 (human)A smad2-smad4 protein complex 2 in human. [PRO:CNA]organism-complexPR:000025968
PR:O15198
mothers against decapentaplegic homolog 9 (human)A smad9 that is encoded in the genome of human. []organism-genePR:000000375; PR:000029067
PR:Q9W734
mothers against decapentaplegic homolog 6 (chicken)A smad6 that is encoded in the genome of chicken. [PANTHER:PTHR13703\:SF20, PRO:DNx]organism-genePR:000000373; PR:000029063
PR:000000484
smad9 isoform 3A smad9 that is a translation product of a mature transcript of the SMAD9 gene, and that contains the MH1 domain and the MH2 domain. Example: UniProtKB:O15198-1. [PRO:CNA]sequencePR:000000375
PR:P84023
mothers against decapentaplegic homolog 3 (chicken)A smad3 that is encoded in the genome of chicken. [OMA:P84023, PRO:DNx]organism-genePR:000000365; PR:000029063
  263 entries | 6 pages | 50 / page |  
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