PRotein Ontology (PRO) Release 29.0 (30-Aug-2012) There are 29726 PRO terms 321 terms are in the 'family' category. 18980 terms are in the 'gene' category. 1560 terms are in the 'sequence' category. 6285 terms are in the 'modification' category. 127 terms are in the 'complex' category. 4 terms are in the 'organism-family' category. 876 terms are in the 'organism-gene' category. 599 terms are in the 'organism-sequence' category. 533 terms are in the 'organism-modification' category. 236 terms are in the 'organism-complex' category. 16 terms are in the 'union' category. 1687 terms have some kind of annotation, codifying the information from 1177 papers. 2466 connections to GO (878 PRO terms). 374 connections to MOD (327 PRO terms). 607 connections to Pfam (363 PRO terms). 338 connections to SO (317 PRO terms). 344 annotations of a phenotype (337 PRO terms). The ontology includes a subset of terms from other ontologies and resources that are used for logical definitions. _New in this release_ 1) Definitions for gene category terms now have a prototype organism indicated (e.g. "human SMAD2"). This is to prevent description duplication when different organisms use the same gene name for different proteins. _Forthcoming changes_ 1) GO molecular function terms to be added to promapping.obo file. 2) Function-based classes (e.g. "kinase") will be created, for automatic classification of annotated proteins 3) General modification classes (e.g. "phosphoprotein") will be created.