PRotein Ontology (PRO) Release 42.0 (15-Jul-2014) There are 60311 PRO terms in the main PRO file: 54 terms are in the 'external' category. 347 terms are in the 'family' category. 23520 terms are in the 'gene' category. 1840 terms are in the 'sequence' category. 6631 terms are in the 'modification' category. 214 terms are in the 'complex' category. 9 terms are in the 'organism-family' category. 23845 terms are in the 'organism-gene' category. 1787 terms are in the 'organism-sequence' category. 1459 terms are in the 'organism-modification' category. 368 terms are in the 'organism-complex' category. 23 terms are in the 'union' category. 2124 terms have some kind of annotation, codifying the information from 1353 papers. 3501 connections to GO (1253 PRO terms). 374 connections to MOD (331 PRO terms). 617 connections to Pfam (371 PRO terms). 338 connections to SO (317 PRO terms). 3 annotations of a phenotype (3 PRO terms). There are 142267 PRO terms in the supplemental promapping.obo file: 89844 terms are in the 'organism-gene' category. 52423 terms are in the 'organism-sequence' category. The ontology includes a subset of terms from other ontologies and resources that are used for logical definitions. _Current changes_ None _Forthcoming changes_ 1) Changes in the annotation file (PAF): a) the relation used for disease terms will be replaced. Instead of agent_in we will use 'associated_with_disease_progression' or 'associated_with_disease_suppression'. Note however that the relation may change in the future as progress on this field occurs. b) the column Equivalent_Form will be removed as it is not longer maintained in this file. _Ongoing_ 1) Continue to add shorthand labels to terms. 2) Continue to expand the set of mapped terms. 3) Resolve names and synonym duplicates.